Search PubMed⌕ Search

Biomedical subjects

E Leete

Publications and source records attributed to E Leete.

At least 19 recordsLinked to original sources
PubMed1996

1-Methylpyrrolidine-2-acetic Acid is not a Precursor of Tropane Alkaloids.

1-Methylpyrrolidine-2-acetic acid and related compounds were studied as precursors in the biosynthesis of the tropane alkaloids in Erythroxylum coca and Datura innoxia. (R,S)-[1',2-(13)C2,2-(14)C,(15)N]-1-methylpyrrolidine-2- acid, (R,S)-[1',2'-(13)C2,1'-(14)C]-1-methylpyrrolidine-2-acetic acid, (R,S) [1',2'-(13)C2,1-(14)C]-1-methylpyrrolidine-2-acetate, and (R,S)-+2'-(14)C] methylpyrrolidine-2-acetic acid N-acetylcysteamine thioester were synthesized an intact plants by leaf-planting or hydroponic-feeding. Specific incorporation of compounds into ( - )-hyoscyamine, ( - )-scopolamine, ( - )-cocaine and the biosynthetically related cuscohygrine were very low. These results indicate that 1-methylpyrrolidine acid is not an efficient precursor of tropane alkaloids.

Alkaloids↗
PubMed1990

Recent developments in the biosynthesis of the tropane alkaloids.

Recent work on the biosynthesis of the tropane moiety of cocaine, hyoscamine, scopolamine, and related alkaloids is reviewed. Revision of the generally accepted biosynthetic pathway to these alkaloids is now proposed in the light of new discoveries. New information on the biosynthesis of some of the acid moieties (benzoic, tiglic and tropic acid) of the tropane ester alkaloids is also discussed.

Acids↗
PubMed1989

How I perceive and manage my illness.

The article describes some of the ongoing problems psychiatric patients encounter on a daily basis as perceived by an individual who has lived with schizophrenia for more than 25 years. Specific carefully planned coping strategies which are seen as critical to the recovery process are presented.

Adaptation, Psychological↗
PubMed1987

The treatment of schizophrenia: a patient's perspective.

The author chronicles her 20-year battle with schizophrenia and her growing acceptance of her illness. She has committed herself to leading the fullest life her disease will allow and to educating others about mental illness. While she does not deny that hospitals have their place in the treatment and stabilization of acute psychiatric problems, she believes community-based residential treatment programs are most successful in promoting long-term gains because they provide a protected yet flexible environment in which to build confidence and social skills. She believes mentally ill individuals need to be educated about their illnesses and require appropriate supportive psychotherapy, pharmacotherapy, access to support groups, and structured activities, such as working, attending school, and training for a job. She describes her own strategies for preventing relapse.

Adult↗