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Biomedical subjects

E Lampainen

Publications and source records attributed to E Lampainen.

32 records · Page 2Linked to original sources
PubMed1982

The nonlinear tissue-binding character of fluoride kinetics in normal and anephric subjects. Graphical analysis of serum fluoride data from man and rabbit.

A study has been made of the fluoride kinetics in man, with a series of 5 healthy subjects and 4 patients with renal insufficiency. The fluoride metabolism was found to conform to nonlinear tissue-binding kinetics. Reanalysis of findings on the rabbit reported in the literature yielded equivalent results. The tissue-binding constants elicited - probably associated with the fluoride metabolism of bone - presented no differences between healthy subjects and uremics. Uremics had a clearly lower fractional fluoride elimination rate (K) compared with the healthy controls. A significant correlation of creatinine clearance on the K value was noted.

Adult↗
PubMed1982

Trauma, renal vein thrombosis and subsequent nephrotic syndrome.

A case of kidney trauma with local and systemic consequences is given. The patient got a trauma to right kidney region. After a fortnights latency nephrotic syndrome developed. Radiological examinations one month after the trauma revealed a partially recanalized thrombus in the right renal vein. It turned out in renal biopsy that the underlying cause of the nephrotic syndrome was acute proliferative glomerulonephritis with typical humps in electronmicroscopy. In contralateral (non-traumatized) kidney there was in renal biopsy the same type of acute glomerulonephritis as well. The course of the renal lesion was documented by a series of renal biopsies which showed improving proliferative glomerulonephritis. The time course of the events and the bilateral histological changes suggest renal trauma as the cause of acute proliferative glomerulonephritis which is a new aspect.

Aged↗
PubMed1976

Significance of a prominent S wave in leads I and V6 in the electrocardiograms of middle-aged and elderly hospital patients.

The significance of a priminent S wave leads I and/or V6 in electrocardiograms of persons aged 30 years or over was studied in 1249 patients who died at hospital. A priminent S wave was found in 4.1% in lead I, in 10.5% in lead V6, and in 2.3% simultaneously in both leads in 171 patients in whom no pulmonary or cardiac disease was observed at autopsy. The occurrence of a prominent S wave in leads I and/or V6 was significantly more frequent in patients with cardiopulmonary diseases than in those without these conditions. This ECG sign was not, however, highly specific for any disease. S wave patterns were frequently found in conditions causing right ventricular overload. The SI and/or SV6 patterns were also common in patients with myohy. It is concluded that a prominent S wave in lead I alone or together with lead V6 in ECGs of middle-aged and elderly patients suggests the presence of a disease affecting the pulmonary criculation or the left ventricle of the heart.

Adult↗
PubMed1976

Mean electrical QRS axis on the frontal plane in electrocardiograms of middle-aged and elderly hospital patients.

The mean electrical QRS axis (AQRS) on the frontal plane was determined on electrocardiograms recorded shortly before death in 1249 patients. Cardiopulmonary diseases were sought at autopsy. Cases with CRBBE, CLBBB, WPW or idioventricular rhythm were excluded. In 171 patients without cardiopulmonary diseases, the AQRS tended to deviate to the left with age. In patients aged 30--49 the median AQRS was +55 degrees ranging between -30 degrees--90. In 99% of older patients, it stayed between -45 degrees--75 degrees. No sex difference was found. A large AQRS deviation was characteristic of patients with cardiopulmonary diseases. In one third of male pulmonary patients aged 50 or over, the AQRS pointed outside -45 degrees or +75 degrees. Rightward deviation of +90 degrees was found in 20% of younger patients. In patients aged 50 or over with myocardial infarction, rightward AQRS deviation of +75 degrees was observed in 11%, and below -45 degrees in 8% of the patients. Abnormal deviation was most common in association with inferoposterior or lateral wall infarctions. Abnormal deviation of the frontal plane QRS axis seems to coincide only with cardiac or pulmonary diseases. Extreme rightward deviation suggests a condition of right ventricular overload, but leftward deviation occurs in patients with pulmonary and with left ventricular diseases.

Adult↗