Biomedical subjects
E L Shaffer
Publications and source records attributed to E L Shaffer.
Frequency and distribution of papillomavirus structural antigens in verrucae, multiple papillomas, and condylomata of the oral cavity.
Sixty-seven proliferous squamous epithelial lesions of the oral cavity were examined for the presence of human papillomavirus whole (structural) virion antigens by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific (common) antigens of the papillomaviruses. A positive reaction for papillomavirus genus specific antigens was found in 18 of 29 verrucae, 2 of 5 multiple papillomas, and 3 of 5 condylomata; common antigens were not detected in 28 keratoacanthomas. The positive reaction was invariably intranuclear in cells having a focal or diffuse distribution in the superficial epithelium. This study shows that a variety of squamous epithelial lesions of the mucosa are associated with human papillomaviruses and suggests that these viruses may play an important role in the etiology of some cases of squamous hyperplasia of the oral cavity.
Oral condyloma acuminatum. A case report with light microscopic and ultrastructural features.
A case of intraoral condyloma acuminatum with clinical, light microscopic, and ultrastructural features is presented. The presence of intranuclear virus particles is demonstrated by electron microscopy. To the best of our knowledge, the presence of viruses has not previously been reported in the oral lessions of this disease.