Biomedical subjects
E L Kendig
Publications and source records attributed to E L Kendig.
Consensus: management of tuberculin-positive children without evidence of disease.
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Smoking in Virginia's hospitals.
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Compensation for vaccine injury.
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Childhood sarcoidosis.
Reports from Yugoslavia, France, Great Britain, Scandinavia, Hungary, and various parts of the United States, make it possible to construct a picture of sarcoidosis in children, its natural history and the influence of corticosteroid therapy.
Abraham Jacobi lecture. The study of tuberculosis in childhood. The evolution of pediatric pulmonology in North America.
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Medical school admissions.
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Tuberculin testing in the young.
The child with a positive tuberculin reaction or uncomplicated primary tuberculosis rarely has symptoms. Since INH prophylaxis for one year will practically always prevent the severe forms of tuberculosis, early diagnosis is essential. An annual or biennial tuberculin test is recommended, and is always indicated when there has been known contact with a tuberculous adult. The Mono-Vacc test is a satisfactory screening device.
Pyridoxine deficiency in children treated with isoniazid.
Isoniazid-induced deficiency of pyridoxine (vitamin B6) is reportedly not uncommon in adults but rare in children. In the present study, 38 children had serum levels of pyridoxine tested while receiving therapy with isoniazid. A biologic assay using the protozoan Tetrahymena thermophila determined pyridoxine status after 2 to 18 months of therapy with isoniazid. Five children (13 percent) were deficient. None had definitive clinical symptoms or signs consistent with pyridoxine deficiency. Three had normal nerve conduction velocity. Children receiving isoniazid in dosages greater than 10 mg/kg/day had a higher incidence of deficiency. Present recommendations for withholding pyridoxine prophylaxis from children receiving isoniazid therapy must be reconsidered in light of these findings, particularly in those children who are debilitated or have a poor nutritional history with a known pyridoxine deficit prior to therapy with isoniazid.
Evolution of short-course antimicrobial treatment of tuberculosis in children, 1951-1984.
Although the first unrecognized indication that short-course antimicrobial treatment of tuberculosis might be effective came in reports of tuberculous meningitis and miliary tuberculosis in children so treated by Lorber (1951 to 1956), the 1977 American Lung Association-American Thoracic Society recommendation for antimicrobial therapy of tuberculosis in adults still specified an 18-month course. The first prospective study on the short-course antimicrobial treatment of children in the United States was published in December 1983. The long delay before recognition of the practicability of short-course antimicrobial treatment of tuberculosis has probably been occasioned by ignorance of drug actions and the mechanisms involved.
Chronic lung disease: inception in childhood.
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Baby Doe: government vs medicine.
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Serum angiotensin-converting enzyme activity in normal children and in those with sarcoidosis.
Serum angiotensin-converting enzyme was measured in 185 children of different ages, in 32 normal adults, in 21 children with sarcoidosis, and in 36 children with other diseases. Children had higher serum ACE volumes than did adults; an intermediate level was absorbed in adolescents. Serum ACE values did not vary according to sex. Children with sarcoidosis had significantly elevated serum ACE levels that closely reflected the activity of the disease. Our results indicate that serum ACE is useful in confirming the diagnosis of sarcoidosis in childhood, and is of greater value as a sensitive indicator for following the course of the disease and the effectiveness of steroid therapy.
An inside look at the Virginia state board of medicine.
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Sarcoidosis in Japanese and American children.
A study of sarcoidosis among Japanese and American children suggests that there are more than the previously suspected number of children with asymptomatic sarcoidosis. The annual chest roentgenogram in Japanese school children detected the majority of these cases, while in the United States, where the annual chest roentgenogram is not required, the majority of children had sarcoidosis diagnosed through symptomatic complaints.