Biomedical subjects

E L Jensen

Publications and source records attributed to E L Jensen.

6 recordsLinked to original sources

PubMed1992

[Acute myelo-meningo-radiculitis caused by the spirochaete Borrelia burgdorferi].

A case of severe myelo-meningo-radiculitis with Lyme neuro-borreliosis is described in a patient aged 33 years suffering from insulin dependent diabetes mellitus. It is essential to examine the cerebro-spinal fluid for Borelia burgdorferi specific intrathecal antibody production if sensory radiculitis persist and, finally, if there are focal motor signs and unexplained lymphocytic pleocytosis in the cerebro-spinal fluid. Early diagnosis is very important in order to shorten the course of the illness and recovery.

Adult↗

PubMed1992

Multiple heteroreceptors on limbic thalamic axons: M2 acetylcholine, serotonin1B, beta 2-adrenoceptors, mu-opioid, and neurotensin.

Ligand binding to many transmitter receptors is much higher in layer Ia of rat posterior cingulate cortex than it is in other layers, and this is where most axons from the anterior thalamus terminate. The present study explores the possibility that a number of receptors may be expressed on axons from limbic thalamic nuclei that terminate in layer Ia. Unilateral thalamic lesions were placed in rats and, 2 weeks later, five ligand binding protocols, coverslip autoradiography, and single grain counting techniques were used to quantify binding in control and ablated hemispheres. Binding to the following receptor subtypes was analyzed: M2 acetylcholine, 3H-oxotremorine-M, or 3H-AF-DX 116 with 50 nM pirenzepine; serotonin1B, 125I-(-)-cyanopindolol with 30 microM isoproterenol; beta 2-adrenoceptors, 125I-(-)-cyanopindolol with 1 microM serotonin and 10 microM atenolol; mu-opioid, 3H-T[r-D-Ala-Gly-MePhe-Gly-ol; neurotensin, 3H-neurotensin. Thalamic lesions reduced binding in two laminar patterns. In one pattern, there was a major reduction in binding in most superficial layers with that in layer Ia ranging from 50 to 70% for binding to M2 muscarinic and serotonin1B receptors. Binding to beta 2-adrenoceptors was also reduced in most superficial layers but to a lesser extent. In the second pattern, reductions were limited to layer I with losses in layer Ia of 20-30% for mu-opioid and neurotensin receptors. In no instance was layer Ia binding completely abolished (i.e., postlesion peaks remained). Since the transmitters for each of the five receptors analyzed in this study are not synthesized by anterior or laterodorsal thalamic neurons, these receptors are heteroreceptors. The greatest postlesion reduction in M2 binding was for AF-DX 116 and so most M2 heteroreceptors are of the "cardiac" subtype. Finally, the diverse population of heteroreceptors on limbic thalamic axons provides for presynaptic modulation by a wide range of transmitter systems and suggests that thalamocortical transmission may not be a simple, unmodulated event.

Atenolol↗

PubMed1991

Milk yield variation concurrent with conception.

Milk yield data from herds at the University of Illinois and the University of Wisconsin-Madison were used to characterize milk yield fluctuations concurrent with conception. Analyses were performed on 118 Illinois and 244 Wisconsin cows; milk yields were recorded for 15 d preceding confirmed conception. Conception was confirmed by calving within 11 d of 281 d postbreeding. Each cow's difference between 7-d rolling means for a.m. and p.m. milking yield was subtracted from a.m. yields as a diurnal adjustment. A pattern matching formula that was applied to adjusted yields [( b - a]/a, where a and b were sequential milkings) produced a mean calculated value for the milking nearest conception that was different from all milkings for 15 d preceding conception in Wisconsin data only. Discriminant analysis failed to differentiate between preceding and conception inclusive sequences of adjusted milk yields. Pattern matching formulas applied to individual cow data failed to isolate more than 2% of conceptions when the threshold value was set to eliminate false positives. Results demonstrated low predictive ability for conception using concurrent milk yield fluctuations despite implications of significant mean differences for values that were enhanced by pattern matching formulas.

Animals↗

PubMed1991

Muscarinic receptor binding increases in anterior thalamus and cingulate cortex during discriminative avoidance learning.

Training-induced neuronal activity develops in the mammalian limbic system during discriminative avoidance conditioning. This study explores behaviorally relevant changes in muscarinic ACh receptor binding in 52 rabbits that were trained to one of five stages of conditioned response acquisition. Sixteen naive and 10 animals yoked to criterion performance served as control cases. Upon reaching a particular stage of training, the brains were removed and autoradiographically assayed for 3H-oxotremorine-M binding with 50 nM pirenzepine (OXO-M/PZ) or for 3H-pirenzepine binding in nine limbic thalamic nuclei and cingulate cortex. Specific OXO-M/PZ binding increased in the parvocellular division of the anterodorsal nucleus early in training when the animals were first exposed to pairing of the conditional and unconditional stimuli. Elevated binding in this nucleus was maintained throughout subsequent training. In the parvocellular division of the anteroventral nucleus (AVp), OXO-M/PZ binding progressively increased throughout training, reached a peak at the criterion stage of performance, and returned to control values during extinction sessions. Peak OXO-M/PZ binding in AVp was significantly elevated over that for cases yoked to criterion performance. In the magnocellular division of the anteroventral nucleus (AVm), OXO-M/PZ binding was elevated only during criterion performance of the task, and it was unaltered in any other limbic thalamic nuclei. Specific OXO-M/PZ binding was also elevated in most layers in rostral area 29c when subjects first performed a significant behavioral discrimination. Training-induced alterations in OXO-M/PZ binding in AVp and layer Ia of area 29c were similar and highly correlated.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1990

Prediction of transmitting abilities for Holstein type traits.

Heritabilities and genetic and phenotypic correlations among 14 linear type traits were estimated from Holstein Association data by multiple trait REML. Data used for parameter estimation were records of 779,391 daughters of 871 sires included in the January 1988 sire evaluation. Each daughter was represented by her appraisal closest to 30 mo of age. Highest heritability was .37 for stature, and lowest was .10 for foot angle. Gains in reliability from using correlated traits in multiple trait prediction were large for some traits (up to 60% for foot angle for cows). Final score variance parameters were estimated from 953,596 records, which were 43% of records included in the national sire evaluation. Sire models that adjusted or did not adjust for merit of mates were compared. Heritability of final score was .27 with adjustment for merit of mates by subtraction of predicted transmitting ability of dam from daughter's record compared with .29 if mate was ignored. Evaluations for type for several popular older sires were reduced moderately by adjustment for merit of mates, but estimated genetic trend increased slightly. An improved genetic grouping procedure that considers group effects as inherited was adapted for use in sire models. Parameter estimates and models presented were implemented by the Holstein Association for computing July 1988 genetic evaluations for linear traits and final score.

Analysis of Variance↗

PubMedDate not supplied

A normal variant simulating Freiberg's disease.

Radiologic examination of the feet was performed in 72 normal persons with no history or physical signs of disease of the feet. In about 10 per cent, bilateral flat configuration of the second metatarsal head accompanied by a joint space wider than in the neighbouring joints was found, and is therefore a normal anatomic variant that must not be confused with Freiberg's disease or its final stages.

Adolescent↗