Search PubMed⌕ Search

Biomedical subjects

E L Gillette

Publications and source records attributed to E L Gillette.

At least 91 records · Page 5Linked to original sources
PubMed1979

Evaluation of gamma radiation therapy in experimentally induced hemorrhagic pancreatitis in dogs.

Acute bile-trypsin pancreatitis was induced in two groups of six dogs each. One group was given supportive treatment only; the second group was treated with irradiation of the pancreas (400 rad). A third group of six dogs was irradiated, but pancreatitis was not induced. A 13-fold increase in survival time was observed in the dogs with pancreatitis which had been irradiated. Irradiation alone was found to reduce the volume of pancreatic secretion with a relative increase in trypsin content. Modification of the inflammatory reaction by irradiation and reduction in pancreatic secretion probably account for the therapeutic effect.

Acute Disease↗
PubMed1978

Electrophoretic evaluation of sera from dogs with cancer.

A quantitative electrophoretic method was developed for evaluating sera from dogs with naturally occurring malignant tumors. Electrophoretic migration ratios (EMR) were devised to standardize characteristic protein components and to analyze alterations in mobility of these protein components, using a computerized densitometric technique. Sera values from dogs with lymphosarcomas, osteosarcomas, and mammary tumors were compared, using conventional methods of statistical analysis. Results indicate a statistical difference existed between mean values of EMR and alpha2-globulins of sera from dogs with tumors and those values from normal dogs. In addition, unique EMR and concentration of protein components were identified for dogs with lymphosarcomas, osteosarcomas, and mammary tumors.

Animals↗
PubMed1976

Radiotherapy of spontaneous fibrous connective-tissue sarcomas in animals.

The clinical records and follow-up data obtained over 13 years on the results of radiotherapy of spontaneous fibrous connective-tissue sarcomas in dogs, cats, and horses were reviewed. The results obtained from the treatment of fibrosarcomas and sarcoids of horses indicated that radiation administered with 60Co is important in the medical and surgical management of these tumors. Fibrous connective-tissue sarcomas in horses were radioresponsive. When radiotherapy was applied postoperatively, the probability of a 2-year cure approached 50% for all prescribed radiation doses of less than 2,000 to greater than 4,000 rads. If radiation doses of 4,500-6,000 rads were used, a 2-year cure rate may approach or exceed 60%.

Animals↗
PubMed1976

Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary colleges.

Three hundred cases of primary neoplasms involving the nasal cavity or paranasal sinuses were found among the reports of 12,300 microscopically confirmed neoplasms. The multispecies data were compiled from abstracts of medical records by 13 colleges of veterinary medicine in the United States and Canada from 1964 to 1973. Significant numbers of neoplasms were observed in dogs, horses, and cats. Intranasal neoplasms were more frequent than those of the paranasal sinuses in dogs and cats. Only cats had a sex difference in the occurrence of nasal neoplasms, with a male predilection. The frequency of neoplasms of the nasal cavity and paranasal sinuses increased with age in all species examined. A clear relationship could not be established between nose length and of intranasal neoplasms. Of the tumors, 80% were malignant in dogs, 68% in horses, and 91% in cats. Detailed review of medical records in a subset of 49 dogs with neoplasms of the nasal passage and paranasal sinuses revealed major clinical signs of nasal and ocular discharge, facial deformity, and stertorous breathing. Median duration of signs prior to diagnosis was 3 months and 95% of the dogs had been given treatment prior to definitive diagnosis. All 49 tumors were malignant; 27 were classified histologically as carcinomas and 22 were sarcomas. Nineteen dogs were treated, using surgery alone or in combination with radiation therapy. Median survival duration was 5 months (mean 6.7 mo).

Adenocarcinoma↗
PubMed1975

Tumor microvasculature following fractionated x irradiation.

The microvasculature of C3H/Bi mouse mammary carcinomas 8 mm in average diameter was evaluated using morphometric methods following six consecutive daily exposures of 500 R of x radiation. Tumor volume did not change significantly during the intervals between treatments. Tumors began to grow again 72 hours after the sixth 550-R fraction, with mean vessel length and surface area reaching maximum values and vessel diameters and volumes becoming minimal at this time. These changes were attributed to improved colloidal-carbon filling of previously existing nonfunctional vessles. When anatomically derived estimates of vascular dimensions were related to a metabolically useful blood supply, improved capability for exchange of essential nutrients occurred 72 hours after the sixth 500-R fraction.

Animals↗
PubMed1975

Endothelial repair of radiation damage following beta irradiation.

Lamellar keratectomy was performed in dogs to induce capillary endothelial proliferation at the limbus of the eye and the radiation response of endothelial cells was evaluated in terms of the dose required to prevent neovascularization in 50% of irradiated eyes (NVD50).Single- and split-dose experiments were carried out before and after induction of proliferation to determine the response of slowly and rapidly proliferating endothelial cells. the NVD-50-S prior to induction were about 400 rads greater than those following induction,indicating increased resistance of slowly proliferating cells. Split-dose studies indicatedthat the radiation repair capability was about 350 rads, either before or after induction.

Animals↗