Search PubMed⌕ Search

Biomedical subjects

E L Gerring

Publications and source records attributed to E L Gerring.

At least 37 records · Page 2Linked to original sources
PubMed1988

Biphasic disruption of fasting equine gut motility by dopamine--a preliminary study.

Dopamine was infused intravenously (1, 5 and 10 micrograms/kg/min) for 60 min in three fasted ponies. A dose-dependent increase in heart rate occurred that was rapid in onset and termination at the start and end of the infusions, respectively. Dose-dependent changes in gastric and small intestinal motility were observed. An initial marked inhibition of gastric contraction amplitude was followed by a secondary prolonged period of activity. At the same time the small intestine showed a prolonged period of irregular activity (phase II) and a marked increase in the interval between successive phase IIIs. The left dorsal colon and small colon exhibited variable responses. The normal fasting motility pattern was therefore disrupted by dopamine biphasically, an initial inhibition of the stomach being followed by a period of increased activity in the stomach and small intestine which resembled the postprandial motility pattern. Although the cardiovascular effects of dopamine were transient, the increases in gastrointestinal motility persisted long after the infusion was terminated.

Animals↗
PubMed1985

Genital tract pressures in mares. I. Normal pressures and the effect of physiological events.

A computerised system involving electronic catheter-tipped transducers was used to measure pressures developed within the vagina and uterus of mares. Larger mares tended to have lower intravaginal pressure than ponies. Insertion of an arm into the vagina to place the catheters caused a rise in intravaginal pressure. Pressure in the uterus was usually higher than that in the vagina. Both vaginal and uterine pressures were increased by urination, snorting, whinnying, stretching and respiration - the latter effect was most noticeable in larger mares. Vaginal pressure was also influenced by peristalsis in the rectum, defaecation, the passage of flatus and the stance of the mare.

Journal Article↗
PubMed1985

The effect of prostaglandin E1 on motility of the equine gut.

Prostaglandin E1 was infused intravenously (25, 50 and 75 ng/kg/min) in three ponies. Changes in gastrointestinal mechanical and electrical activity were recorded from chronically implanted strain-gauge force transducers and electrodes. Dose-dependent responses were obtained: there were significant decreases in electrical spiking activity in the stomach, left large colon and small colon, with a corresponding decrease of activity in the left dorsal colon mechanogram. The small intestine was also affected, showing a decrease in both contraction rate and amplitude, which was more marked in the proximal jejunum than in the ileum. There was an association between these changes in gastrointestinal activity and the presence of discomfort and diminished gut sounds.

Alprostadil↗
PubMed1985

Tendon injuries in horses treated with carbon fibre implants.

Implants of carbon fibre, made by plaiting a tow of 10,000 filaments of Grafil type HT-S, were used to treat strains and ruptures of digital flexor tendons in 46 horses. The relevant clinical data, the techniques employed and an analysis of the results are described. Apart from two horses in which the implant was extruded and had to be removed, there were minimal untoward consequences of the surgery. Of the 34 horses with acute or chronic tendinitis, 14 returned to racing, seven were used as hunters and seven as hacks. Among the former group, seven suffered a further strain while racing but the others performed well for some time. Twelve horses with severed tendons recovered well and only in one did infection occur. Overall the results in the latter were better than had previously been achieved using other repair materials.

Animals↗
PubMed1985

Effect of experimental vascular occlusion on small intestinal motility in ponies.

Small intestinal ischaemia is a cause of pain in man and horses. Occlusion of the vascular supply to Thiry loops in experimental ponies caused severe discomfort and loss of motility within a few minutes but these effects could not be reproduced by a similar procedure in intact gut preparations. However, embolisation of the mural vascular network produced ischaemia of the small intestine of anaesthetised ponies which led to a cessation of motility in the affected segments, though unaffected segments became hypermotile with a characteristic motility pattern. These results suggest the need for reappraisal of the classical theory of parasite-induced damage to the cranial mesenteric artery as the cause of ischaemic bowel disease.

Animals↗
PubMed1984

Persistent vaginal haemorrhage in five mares caused by varicose veins of the vaginal wall.

Persistent bleeding from the vulva was the only presenting clinical sign in five non-pregnant pluriparous mares varying in age from eight to 20 years. These were two hunter types, one shire, one thoroughbred and one Arab pony. The haemorrhage originated from ulcerated varicose veins present on the dorsal wall of the vagina adjacent to the vestibulovaginal junction. All five mares were successfully treated, by submucosal resection (two), ligation of vessels (two) or diathermy (one). In four mares there was evidence of vulval incompetence caused by depression of the perineum. The importance of this and the role of impaired venous return during and after pregnancy are discussed.

Animals↗
PubMed1984

Fetlock annular ligament desmotomy: a report of 24 cases.

Restriction of free movement of the flexor tendons through the fetlock canal results in lameness. The commonest cause was chronic synovitis of the digital sheath. The condition is characterised by an unremitting lameness, synovial distension and a notch on the caudal aspect of the limb. The condition can be relieved by section of the annular ligament of the fetlock. In a series of 24 cases 16 horses returned to work with no recurrence of lameness, three cases were lost to follow up and five animals remained lame; three of these had intercurrent disease.

Animals↗
PubMed1983

Biochemical and haematological effects of a revised dosage schedule of phenylbutazone in horses.

Five pairs of matched horses were used to study the biochemical and haematological effects of a revised dosage schedule of phenylbutazone. One group of five horses received a phenylbutazone paste formulation daily for 12 days and a second group of five animals received a placebo preparation for a similar time. Some statistically significant differences were recorded from pretreatment levels in both groups of horses. These changes represented instability in baseline levels and could not be ascribed to phenylbutazone administration.

Animals↗
PubMed1983

Electromechanical activity of the equine small intestine and its correlation with transit of fluid through Thiry-Vella loops.

Motility patterns in the equine small intestine were investigated in eight ponies. Muscular activity was assessed by means of extramural strain gauge transducers, bi-polar electrodes and in three of the animals, fitted with Thiry-Vella loops, the transit of fluid. Circular muscle contractions were preceded by spiking superimposed on the slow wave and fluid transit in the loops correlated with both these events.

Animals↗
PubMed1983

Effect of spasmolytic analgesic drugs on the motility patterns of the equine small intestine.

The effect of acepromazine, Buscopan (Crown Chemicals), pethidine and methadone was evaluated in ponies prepared with Thiry-Vella (T-V) loops. Motility was assessed by electrophysiological means (bipolar electrodes and strain gauge transducers) and by the passage through the T-V loop of a fluid test meal. Results were obtained from 26 experiments in three ponies and compared with six control experiments, in which saline had been administered to the same ponies. Each pony acted as its own control in each experiment and pre and post treatment values for slow wave frequency, spiking activity, delivery rate and flow rate were compared. Acepromazine reduced electrical activity, but increased volume transport. Buscopan produced little change, while pethidine and methadone both decreased electrical activity, but increased volume transit. These effects may be due to a decrease in tone with resulting increase in luminal volume of the intestine.

Acepromazine↗