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Biomedical subjects

E Kuhn

Publications and source records attributed to E Kuhn.

At least 91 records · Page 5Linked to original sources
PubMed1978

[Cardiomyopathies].

A) Definition and classification. Cardiomyopathy is defined as a dysfunction of cardiac muscle of unknown origin and classified according to genetic, morphological and functional criteria as follows: 1. cardiomyopathy of autosomal dominant inheritance with asymmetric septal hypertrophy (ASH) a) obstructive b) non obstructive 2. cardiomyopathy of autosomal dominant inheritance without ASH 3. cardiomyopathy of autosomal recessive inheritance 4. sporadic cardiomyopathy. It is assumed that at least the cardiomyopathies listed here are heterogeneous groups that have to be subdivided as soon as further discriminating findings--structural or enzymatic--are available. B) Diagnosis, prognosis, treatment. The diagnostic methods are evaluated, the prognosis and the treatment of the cardiomyopathies are reviewed.

Adrenergic beta-Antagonists↗
PubMed1978

[Increased insulin secretion in dystrophia myotonica].

Serum insulin levels were determined in patients with myotonic dystrophy after intravenous administration of glucose and were found to be higher than in control persons in about 60%. Although several interpretations of this observation are possible we favor the assumption, that an increased sensitivity of the insulin producing system of the pancreas is the reason. With regard to the most accepted hypothesis that myotonic dystrophy is a disorder due to impaired membrane function, it is tempting to explain our findings by an altered membranal function of the insulin producing cells, too.

Humans↗
PubMed1978

The effect of glucagon on free plasma amino acids in cirrhotics and healthy controls.

The effect on free plasma amino acids before and after infusion of 1 mg glucagon was studied at rest after an overnight fast in seven patients with compensated liver cirrhosis and in seven healthy controls. Total aminoacidaemia in cirrhotic patients is significantly higher than in controls. Elevated basal levels in cirrhotics are found particularly in tyrosine, citrulline, tryptophane, threonine, phenylalanine, and methionine whereas ornithine and serine levels are decreased. Save for the redox couple cystine-cysteine which increases, glucagon elicits an decrease in most amino acids that is proportionate to their initial level. Total aminoacidaemia decreases in controls and cirrhotics by 14.6 and 9.1 per cent respectively. Serum ammonia level rises significantly in both groups, urea increases only in controls, uricaemia remains virtually unchanged.

Amino Acids↗
PubMed1977

[Importance of inheritance in cardiomyopathies (author's transl)].

Inheritance plays an important role in the cardiomyopathies (i.e. dysfunction of the cardiac muscle of unknown origin). This especially has become obvious for the entity asymmetric septal hypertrophy of autosomal dominant inheritance (ASH), a cardiomyopaty with and without obstruction. But this is not the only type of cardiomyopathy of dominant transmittance as was shown by the demonstration of a kindred, in which echocardiographically no hypertrophy of the septum could be found. For it was not possible to find a uniformity for all the affected members of the kindred, for example a congestive course of the disease. Therefore it is suggested to name the disease without any prejudice "cardiomyopathy without asymmetric septal hypertrophy of dominant inheritance" to distinguish it from the "cardiomyopathy with asymetric septal hypertrophy of dominant inheritance". There also may occur a cardiomyopathy of autosomal recessive inheritance. This form could represent a large part of the "sporadic" cardiomyopathies and should challenge to search intensively for enzyme defects as a cause of the disease.

Cardiomyopathies↗
PubMed1977

[Importance of the inheritance in non-ejection-click and click-murmur-syndrome (author's transl)].

In a recent examination of the kindreds of 60 patients with a systolic non-ejection-click or click-murmur-syndrome we were able to demonstrate that the findings in 36 kindreds are inherited, although in most of the families not all the members could be seen. This means about 60%, a quote that might be even higher if all the members of a kindred could have been examined. Our observation suggests an autosomal dominant inheritance. This makes it worth while to look for the genetic defect causing this finding.

Adolescent↗
PubMed1976

[Myotonia].

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2,4-Dichlorophenoxyacetic Acid↗