[Medical consequences of a nuclear war].
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Biomedical subjects
Publications and source records attributed to E Kringlen.
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An earlier study of smooth-pursuit eye movements (SPEMs) in monozygotic (MZ) and dizygotic (DZ) twins discordant for functional psychosis reported high concordance of pursuit abnormalities in MZ pairs and moderate concordance in DZ pairs. That study was repeated with younger pairs of twins and with some quantitative refinements in scoring. Results show the same levels of concordance for pursuit dysfunctions, thus replicating the earlier study. The data support an interpretation of genetic factors contributing to variability in SPEMs.
A brief description is given of the diagnostic concepts used in Nordic psychiatry, followed by a review of schizophrenia research over the last 40 years. The author has focused attention on research on heredity/environment, and investigations concerning prognosis and outcome, since it was felt that most of the significant research has been done in those areas. Newer twin studies as well as family studies have probably led to a less fatalistic view of schizophrenia. Catamnestic studies support Anglo-American investigations which show a variable course of schizophrenia. As in other countries, studies reveal that the outcome of schizophrenia has improved considerably in the Nordic countries.
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Disordered smooth-pursuit eye movements occur in a high percentage of schizophrenic patients and their first-degree relatives. A Test of the hypothesis that these disorders represent a genetic indicator of schizophrenia was undertaken by testing pursuit eye movements in a sample of monozygotic and dizygotic twins discordant for clinical schizophrenia. Deviant eye tracking is significantly concordant within monozygotic twin pairs, and less so with dizygotic twin pairs discordant for schizophrenia. A genetic interpretation is consistent with these results.
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