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Biomedical subjects

E Kragelund

Publications and source records attributed to E Kragelund.

At least 19 recordsLinked to original sources
PubMed1984

Spontaneous healing of duodenal ulcers.

Ninety-one patients with duodenal, pyloric, or prepyloric ulcers were studied endoscopically. Spontaneous ulcer healing was seen in 29 patients within 2 weeks (rapid healing) and in 23 patients within 6 weeks (slow healing). More ulcers healed spontaneously in women than in men (P less than 0.05). Spontaneous healing in men was related to a low gastric peak acid output (P less than 0.05). During follow-up study for 2 years of patients with spontaneously healed ulcers 13 patients had no recurrence, whereas 19 patients had 1 or 2 recurrences, which also healed spontaneously; 11 patients had to be given active treatment, and 9 patients did not complete the study. Cigarette smoking was more frequently recorded in the group receiving active treatment than in the group with spontaneous healing. In men ulcers needing active treatment during the follow-up period were related to a high peak acid output (P less than 0.05).

Adult↗
PubMed1976

Basal and meat extract plasma gastrin before and after parietal cell vagotomy and selective gastric vagotomy with drainage in patients with duodenal ulcer.

Basal and meat extract stimulated plasma gastrin (PG) levels and basal and stimulated gastric acid secretion were evaluated pre and postoperatively in duodenal ulcer patients who underwent parietal cell vagotomy without antral drainage (normal duodena) (PC, n=32) or selective vagotomy with drainage (pyloric stenosis) (SV +P, n=11). Before operation, both groups had comparable basal PG values of 52+/-13 pg/ml (PCVP) AND 51+/-18 PG/ML (SV+P), while the peak gastrin level to meat extract stimulation was 173+/-40 pg/ml for the total group of patients. After both operations basal PG levels increased (107+/-18 pg/ml (PCV) and 152+/-45 pg/ml (SV+P) and the gastrin response to meat extract stimulation was augmented after PCV, while the response after SV+P was the same as before operation. Patients with PCV often demonstrated an acid response following meat extract stimulation (3.6+/-0.9 mEq HC1/hr), and pentapeptide stimulation (18.8+/-2.0 mEq/hr) while patients with SV/P showed a minimal response (1.3+/-1.2 mEq HC1/hr meat extract), and 10.7+/-1.8 mEq/hr pentapeptide stimulation. The comparatively intact acid response in the PCV patients may augur a high ultimate recurrence rate.

Adult↗
PubMed1975

Accidents and complications in selective and proximal gastric vagotomy.

In 3 years 266 consecutive patients were electively operated on for ulcer disease with either selective vagotomy (SV) with drainage (159) or proximal gastric vagotomy (PGV) without drainage (107). The total number of operative accidents was 15 (6 percent), similar to that of truncal vagotomy. Perforation of the stomach occurred in six SV and in one PGV. The perforation went unobserved in two patients, of whom one died. Esophageal perforations were not observed. Bleeding from the lesser omentum or from the spleen was seen in seven patients, requiring reoperation in one. Postoperative surgical complications were seen in 25 patients (9 percent): clinical gastric retention was observed in nine patients, five with SV and four with PGV, and 13 had wound abscesses or dehiscence. Fifty-nine patients had other complications, of which 52 were radiologically demonstrated atelectases, mostly without any clinical significance. The total mortality rate was 1.1 percent, similar to that of truncal vagotomy. The duration of the two operative procedures did not differ, and the greater care required for preservation of the nerve of Latarjet tended to diminish the number of operative accidents.

Adult↗