Search PubMedSearch

Biomedical subjects

E Koob

Publications and source records attributed to E Koob.

18 recordsLinked to original sources

Training in basic microsurgical techniques without experiments involving animals.

Until recently, anaesthetised rats have been the usual material employed for learning basic microvascular and microneurosurgical techniques. However, ethical considerations, the costs involved and legislation controlling experiments with animals allow training in microsurgery for extended periods of time at a few medical centres only. This paper reports on our experience of an alternative training programme largely conducted without using live animals. As the basic material we selected legs of slaughtered pigs. According to the developing skill of the trainee, basic microsurgical techniques can be practised on arteries and veins of various sizes in these legs. To verify positive results, the vessels are subsequently perfused with human blood under pressure. The model described is particularly suited to the acquiring of skills in microneurosurgery. Mono-, oligo- and polyfascicular nerves, structurally similar to the configurations found in human extremities, are found in pig legs. The ever-increasing importance of microsurgery in modern medicine requires more and more surgeons and orthopaedists to familiarize themselves with these techniques. The model we propose for teaching and training substantially facilitate such further professional training in an efficient way, and at the same time allows a substantial reduction in the number of experiments conducted on animals.

Animal Testing Alternatives

[A realistic practice model for learning microneural surgery without experiments on live animals].

The increasing importance of microneurosurgery in hand and plastic surgery makes it necessary for surgeons to familiarize themselves with these techniques. In most training programs, anesthetized rats have been used to learn basic microneurosurgical techniques. Ethical considerations, the costs involved, and the legislation concerning experiments with live animals permit extensive training in microneurosurgery in only a few medical centers. This paper relates our experience with an alternative training program not involving live animals. Instead, we chose the legs of slaughtered pigs. Mono-, oligo-, and poly-fascicular nerves, structurally similar to the configurations found in human extremities, can be found in pig legs. Neurolysis, primary nerve sutures, and nerve transplantations can be practiced.

Animal Testing Alternatives

[Long-term spontaneous course of carpal instability].

The authors report on the natural history of 26 cases of carpal instabilities observed over a period of 25 to 74 months. Apart from the subjective criterion pain, the parameters range of motion and grip strength have been documented in the course of their development. In addition, radiographic findings have been evaluated. We confirm that carpal instabilities can lead to degenerative arthrosis. The expectation that there would be a progressive deviation from the norm of the angles between radius, scaphoid, lunate, and capitate bones measured in lateral radiographs did not prove to be true.

Adult

[Isolated compression of the dorsal branch of the ulnar nerve].

The dorsal branch of the ulnar nerve was dissected in 20 upper extremities. The nerve arises from the ulnar aspect of the ulnar nerve at an average distance of 8.5 centimeters from the proximal border of the pisiforme. It courses deep to the palmar carpal ligament and pierces the ligament dorsal to the tendon of the flexor carpi ulnaris, becoming subcutaneous. The palmar carpal ligament has been found to be a cause of isolated entrapment of the dorsal branch of the ulnar nerve. A report of eleven operative cases is presented.

Adult

[The supinator syndrome--an anatomical and clinical study].

The interosseus posterior syndrome appears in two forms: a) the paralytical interosseus posterior syndrome, b) the painful (afferent) interosseus posterior syndrome. We report in this investigation about 12 operated patients with painful interosseus posterior syndrome. The intraoperative findings in the arcade of Frohse are compared with the findings we made at the preparation of 10 recently deceased. It was especially significant, that we found in 10 of our 12 cases intraoperatively a tendinous type of arcade. In our directioned cases we encountered this type of tendinous arcade in only 2 of 10 cases. Based on these findings we are of the opinion that the tendinous arcade of Frohse is an important factor in the development of the interosseus posterior syndrome.

Adult

[The supinator syndrome. An anatomic and clinical study].

The posterior interosseous syndrome appears in two forms, a) paralytical, and b) painful. In this investigation the authors report on twelve operated patients with painful posterior interosseous or "radial tunnel" syndrome. The intraoperative findings in the arcade of Frohse are compared with the findings on preparation of ten recently deceased. It was especially significant that in ten of twelve cases there was found intraoperatively a tendinous type of arcade. In the cadaveric studies the authors encountered this type of tendinous arcade in only two of ten specimens. Based on these findings, the authors conclude that the tendinous arcade of Frohse is an important factor in the development of the posterior interosseous syndrome.

Adult

[Treatment results in fractures and pseudarthrosis of the scaphoid bone].

In 258 patients with fractures and pseudarthroses of the carpal scaphoid the cause and type are given and the results of treatment are presented. It is verified that the majority of fresh fractures are united by plaster immobilisation. In fractures with delayed healing and in cases with non-union the best results are achieved by autologous bone grafting.

Adolescent