Search PubMed⌕ Search

Biomedical subjects

E Koch

Publications and source records attributed to E Koch.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Skin tolerance of topical corticoids as dependent upon the pH value of the emulsions].

Two new hydrocortisone esters, EMD 33 702 and EMD 33 714, each with an activity of 0.1% concentration approximately equivalent to that of 1% hydrocortisone acetate were selected for the development of new topical corticoid preparations. The stability of these steroids is dependent on the pH value of the vehicles. Thus, it was necessary to adjust the pH values in the tested creams (Cremegrundlage a, Cremegrundlage IXa) to pH 8 for EMD 33 702 and to pH 4 for EMD 33 714. In order to assess the skin tolerance of these creams the following investigations on human skin have been carried out. 1. During chamber test on normal skin (14 d) and 2. on scarified skin (3 d); 3. Test on the functions of the horny layer before and after 3 weeks treatment (alkali resistance test, nitrazin test after stripping, ammonium hydroxid blister test; n = 8). Additionally, vasoconstriction tests were carried out to assess the activity as a function of the different pH values in the cream formulations. The skin tolerance of the creams a and IX a and their steroid containing preparations was good on normal as well as on scarified skin. Differences in skin tolerance dependent on the pH value of the creams (pH 4-pH 8) could not be determined. Compared with this a cream with 10% carbamide (pH 8) was very irritating and scarified skin and a cream with 10% carbamide and 5% lactic acid showed very irritating reactions on normal and scarified skin respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Topical↗
PubMed1982

[Alexander's disease (author's transl)].

A report on clinical course and morphological findings in a case of Alexander's disease is given in a boy aged 4 year and 6 months. The disease started in the second month with progressive retardation. At the age of 13 months, a ventriculo-peritoneal shunt was performed because of dilatation of ventricles. Death occurred due to cerebral dysfunction. Microscopic investigation showed a considerable demyelination and the presence of numerous Rosenthal fibers. The results are compared with observations in the literature of Alexander's disease during early infancy.

Autopsy↗
PubMed1980

[Cefazedone-results of a multicentre clinical test (author's transl)].

Cefazedone (Refosporin) was tested for efficacy and tolerance in 1161 patients. The trial was interrupted or unsuitable for evaluation in 54 cases. Diagnostical characteristics of the remaining 1107 patients tested for tolerance were: therapeutical and prophylactic use in surgery (37,5%) infections of the bronchial tract (30.8%), infections of the urogenital tract (17.9%), infections of the abdominocystic tract (6.2%), other infections (7,6%). Of the 1085 patients tested for efficacy--in 22 cases the trial was interrupted because of undesired side effects (exanthema, nausea, local intolerance)--87% concerned exclusively antibiotic therapy with cefazedone. Cefazedone was administered only twice daily i. v. Combined medication with other antibiotics--mainly amino glycosides--was highly efficient.

Bacteroides↗
PubMed1979

[Clinical evaluation of cefazedon on patients with urinary tract infections (author's transl)].

The efficacy and tolerance of Cefazedon, a new antibiotic, was investigated clinically on 90 patients with urinary tract infections who also required surgical treatment. Good clinical results were achieved in over 90% of patients after 6 to 7 days of treatment. The bacteriological examination revealed complete elimination of the initially identified pathogens in 89 cases. No difference in treatment results could be established when applying the dose 2 or 3 times daily. On the third day of treatment skin reactions were observed in one case which necessitated discontinuation of treatment. Laboratory blood values as well as control of liver and kidney function before treatment, after and one week past treatment showed no negative influence due to the drug. In approximately 27% a new colonisation mainly with Pseudomonas could not be prevented.

Adult↗
PubMed1979

Simulation and prevention of retrovirus--specific reactions by mycoplasmas.

From human mycosis fungoides tumor-derived cell lines, Mycoplasma hyorhinis was isolated. This mycoplasma shared the following characteristics with retroviruses: uptake of 3H-uridine, but not of 3H-thymidine in cell culture; banding at 1.16 g/ml sucrose density and partial shift to retrovirus core density position (approximately equal to 1.24 g/ml) after detergent treatment; incorporation of 3H-TMP into high molecular weight material in standard reverse transcriptase assays with the template-primer poly (A) . (dT)12. On the other hand, the specific reverse transcriptase reaction of retroviruses with poly(A) . (dT)12 and poly(C) . (dG) approximately 16 was almost completely abolished in the presence of the mycoplasma. Thus, M. hyorhinis may interfere with identification and isolation procedures for retroviruses.

Cell Line↗
PubMed1979

[Cefazedone in infectious diseases in gynecology. Clinical tests on efficacy and tolerance].

A clinical trial on efficacy and tolerance of Cefazedone, a new semisynthetic Cephalosporine-derivate, was carried out in a gynaecological clinic on 75 patients. In 38 of these cases, besides the gynaecological affection, urinary tract infections were determined microbiologically (E. coli, P. mirabilis, klebsiella or enterococci). Inflammation of the lower abdominal area was established in the remaining 37 patients (adnexitis, pelvic peritonitis, endometritis, salpingitis). The average duration of treatment was 10 to 11 days. Cefazedone was injected intravenously twice a day, the daily dose was 2 to 4 g. The clinical assessment of the treatment was very good in 28 cases, good in 43 cases, moderate in 3 patients and poor in 1 case. All initially identified pathogens were eliminated after treatment. A slight transitory diarrhea was observed in 5 cases. There were no further side-effects. The values of gamma-GT, serum-creatinin, hemoglobin and erythrozytes were controlled before and after medication and showed no detremental effect of the drug. The local tolerance of Cefazedone was good in more than 90% of the cases treated.

Adult↗
PubMed1979

[Efficacy and tolerability of cefazedone in infectious skin diseases; determination of serum and tissue concentrations (author's transl)].

The efficacy and tolerance of Cefazedone, a new Cephalosporin derivate, were investigated in an open clinical trial on 40 patients with bacteriological skin infections. Patients with Erysipelas, impetiginized dermatoses and Pyodermia were treated during an average period of 9 days mainly with a dosage of 2X1 g i.v., in some cases with 2X2 g i.v. daily. The success of the treatment was good--very good in 92% of the cases. All pathogens isolated before treatment (Streptococci, St. aureus, E. coli) were eliminated after treatment. 2 patients showed transitory incompatibility reactions due to too rapid injections. The local and systemic tolerance were excellent in all other cases. 1 hour after i.v. injection of 1 g Cefazedone to 20 patients the mean concentration in the serum was 51 micrograms per ml and in the skin-tissue 10.6 micrograms/g.

Adult↗