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Biomedical subjects

E Kleihauer

Publications and source records attributed to E Kleihauer.

At least 109 records · Page 6Linked to original sources
PubMed1975

Transplacental passage of foetal blood cells.

With the brightly fluorescent Y chromatin as a marker, the proportion of foetal lymphocytes in maternal blood was found to be 0.02-0.16% in 7 of 11 primigravidae bearing a boy, but not a single XY mitosis was found among 112,000 leucoagglutinin-stimulated mitoses from the same women. The proportion of foetal lymphocytes did not change appreciably during pregnancy (first appearance detected at 15 weeks' gestation), nor were there any unequivocal foetal erythrocytes in spite of ABO and Rh compatibility. These findings suggest that foetal lymphocytes pass actively into the mother's blood relatively early during pregnancy. The cells are protected from immunological elimination, and therefore may remain in the maternal blood for long periods. They are a valuable potential source of material for antenatal foetal diagnosis.

Adult↗
PubMed1975

Congenital stomatocytosis and chronic haemolytic anaemia.

A new case of congenital stomatocytosis associated with haemolytic anaemia, increased autohaemolysis, abnormalities in the erythrocyte metabolism, increased osmotic fragility and shortened erythrocyte survival is described. Intracellular cation concentrations are abnormal: Red cell sodium is high, and potassium is low. The pump rate for monovalent cations is increased.

Adenosine Triphosphatases↗
PubMed1975

[Diagnosis and therapy of primary defects of immunity (author's transl)].

Immunological responses are divided into those mediated by humoral antibody (B-Cells) and those by cells (T-Cells). Both depend upon the activity of small lymphocytes which become thymus or bursa analogue dependent during embryonic development. Primary immundeficiencies are therefor defects of lymphocytes attributed in most cases to gene defects. Early diagnosis is the necessary prerequisit for possible treatment. Tests for assessing the cellular immune status are: skin testes and in vitro tests. Clinical syndroms are: lymphocytopenia, hypoplasia, deficiency of lymphocytes in lymphatic tissues normal cortical germinal centres. Recurrent infections with viruses, candida or pneumocystis carinii are common. Tests for assesing the humoral immune status are: measurement of immunglobulin levels in serum, isohaemagglutinins, tests for antibody formation following active immunization, in vitro tests. Clinical syndroms are: no germinal centres in lymphnodes, no plasma cells. Recurrent bacterial infections. Treatment of B-cell deficiencies: immunglobulin replacement therapy. Treatment of T-cell deficiencies by grafting of thymus transplants. Combined immune deficiencies are treated with bone marrow transplants from matched donors. For bone marrow transplantation germfree state seems to be the ideal situation to protect the patient against infection before the therapeutic maneuver and for prevention of graft versus host reaction in the posttransplantation period.

B-Lymphocytes↗