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Biomedical subjects

E Kiss

Publications and source records attributed to E Kiss.

198 records · Page 11Linked to original sources
PubMedDate not supplied

Systemic lupus erythematosus survival in Hungary. Results from a single centre.

OBJECTIVE: Systemic lupus erythematosus survival has improved worldwide. The authors present the first Hungarian survival results, analysing retrospectively data on 532 lupus patients who were followed at a single centre over the past 25 years. RESULTS: Survival of SLE patients has improved in Hungary as indicated by the results of life-table analysis, and the increase in both the five- and ten-year survival rates. The outcome was less favourable for males and for patients under 20 and over 50 years of age at the time of diagnosis. The mortality ratio decreased with disease duration, and the risk of death due to SLE was the highest within the first five years of the disease. The majority of young lupus patients were lost within this period. The mean cause of death was renal insufficiency in the younger patient population and in the early phase of the disease. Heart failure and a naturally increasing mortality rate must be taken into consideration in the patient group over 50 years of age. The prognostic importance of clinical and laboratory symptoms of SLE was determined by the calculation of relative risks. Skin eruptions positively influenced the outcome, while valvular heart disease, interstitial lung disease and haematological manifestations had a negative impact on survival. Surprisingly, renal and central nervous system involvement did not significantly influence survival. The number of patients who were lost to regular follow-up diminished. CONCLUSIONS: The present study indicates an improvement in lupus survival in Hungary. Survival is affected by age and gender differences and may also be influenced by the race and ethnic origin of the patients. Regular follow-up is an important factor in lupus survival.

Adolescent↗
PubMedDate not supplied

[Speciation of bioactive Al(III) and VO(IV) complexes in biological systems].

The speciation of the toxic Al(III) and the beneficial VO(IV) in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in the organism. The possibility and the importance of ternary complex formation with relevant biomolecules is emphasised. The importance of the biospeciation of Al(III) ion in its transport and involvement in neurological disorders, and of insulin mimetic VO(IV) complexes is discussed.

Aluminum↗
PubMedDate not supplied

Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD).

OBJECTIVE: To determine the clinical symptoms and the panel of autoantibodies of patients with early undifferentiated connective tissue disease (UCTD) followed for at least 1 year. METHODS: 716 UCTD patients with manifestations suggestive but not diagnostic of specific connective tissue disease (CTD) were recruited and followed up between 1994-1999. The patients with early UCTD were subdivided into those with isolated Raynaud's phenomenon (RP) (50 patients), unexplained polyarthritis (31 patients) and "true" UCTD (665 patients). UCTD was diagnosed on the basis of clinical manifestations suggestive of a connective tissue disease and the presence of at least one non-organ specific autoantibody. The patients' sera were tested for anti-nuclear (ANA), as well as for nine different specific autoantibodies (anti-dsDNA, -Sm, -RNP, -SSA, -SSB, -Scl-70, -centromere, -Jo1 and -PM-Scl). RESULTS: The most common clinical manifestations of UCTD included RP, arthritis/arthralgias, pleuritis/pericarditis, sicca symptoms, cutaneous involvement (photosensitivity, rash), central nervous symptoms, peripheral neuropathy, fever, vasculitis, less pulmonary involvement and myositis. 230 of the 665 true UCTD patients (34.5%) developed a defined CTD (28 systemic lupus erythematosus [SLE], 26 mixed connective tissue disease [MCTD], 19 progressive systemic sclerosis [PSS], 45 Sjögren's syndrome, 3 polymyositis/dermatomyositis [PM/DM], 87 rheumatoid arthritis [RA], and 22 systemic vasculitis. 435 of 665 patients (65.4%) remained in the UCTD state, and 82 of 665 patients (12.3%) achieved complete remission with symptoms not reappearing within the 5-year period. The highest probability of evolution to a defined CTD was during the first 2 years after onset: of 230 UCTD patients 183 (79.5%) developed major organ symptoms and signs. In particular skin and cardiac complications seemed to spread during the follow-up period in those patients who progressed to SLE. The condition of 18/50 patients with isolated RP evolved to UCTD and 3 of 31 patients with unexplained polyarthritis progressed to definite CTD (2 patients RA and one MCTD). CONCLUSION: In our study most of the UCTD patients did not develop a definite CTD, but during the follow-up period we found new clinical and serological manifestations. One-third of the UCTD patients showed progress into different types of specific CTD.

Adolescent↗
PubMedDate not supplied

[Distribution of subtypes of viral hepatitis B antigen in areas of Rumania].

The results of subtyping the B antigen in 551 sera from patients with viral hepatitis, chronic evolutive hepatitis and cirrhosis, chronic carriers, donors and healthy subjects, were confirmed as positive HBAg by diffusion in agar, counterelectrophoresis and radioimmunology, and characterized by the d-y and w-r determinants by rheophoresis. The high incidence of the y determinant in all nine counties investigated probably reflects the prevalence of this serotype in Romania, recalling the distribution of subtypes observed in the south of Europe.

Adolescent↗
PubMedDate not supplied

Prevalence of HBsAg and anti-HBs among delivering women.

A survey of 2,500 delivering women revealed a 7.6% incidence of past infection with hepatitis B virus (HBV) (HBsAg or anti-HBs). Only 5.9% of the anti-HBs-positive mothers had a possible history of parenteral exposure to hepatitis B and none of the 55 HBsAg carriers had such a history. The findings suggest that HBV is endemic and that it is probably spread in part by nonparenteral means. The high rates of HBsAg and anti-HBs point to the possible preventive value of routine screenings for this system among pregnant women.

Adolescent↗
PubMedDate not supplied

Serologic markers of hepatitis B and A infections in the healthy population.

The prevalence of the serologic markers of hepatitis B virus (HBV) and of antibodies to hepatitis A virus (HAV) were determined by radioimmunoassay in 200 healthy subjects. One hundred and seven persons (53.5%) were positive for at least one marker of HBV. The prevalence of each marker was: HBsAg - 9.0%, anti-HBs alone - 2.0%, anti-HBc alone - 2.5%, anti-HBs and anti-HBc - 29.0%, HBsAg and anti-HBc - 11.0%. Evidence of a previous infection with HAV was found in 155 persons (77.5%); three of them had anti-HAV type IgM. These findings indicate that in the area investigated HAV infection is endemic, and HBV infection has a trend towards endemicity.

Adolescent↗
PubMedDate not supplied

Influence of uridine treatment in mice on the protection of gastrointestinal toxicity caused by 5-fluorouracil.

C57B1/6 male normal mice were treated with 5-FU (200 mg/kg i.p.) alone or in combination with a bolus injection of uridine (2 x 3500 mg/kg i.p.) in order to study the potential rescue effect of uridine on 5-FU-induced gastrointestinal toxicity. 5-FU alone inhibited the activity of different enzymes (thymidine-kinase, alkaline-phosphatase, sucrase and maltase) which were selected as the early biochemical markers for the injured small intestinal mucosa. The nadir of the enzyme activities was between 24-96 hrs after 5-FU administration, and the complete regeneration took a week. In the combination of 5-FU plus uridine bolus injection the seriousness of gastrointestinal damage caused by 5-FU was significantly (p < 0.05) milder and the recovery time was shorter by 2 days. Comparing the rescue effect of two dose schedules of uridine, both high dose (2 x 3500 mg/kg) or repeated lower doses of uridine (7 x 800 mg/kg) resulted in a similar protection from the gastrointestinal side effect of 5-FU.

Alkaline Phosphatase↗
PubMedDate not supplied

Distribution of hepatitis B virus subtypes in Romania.

The higher incidence of HB8Ag/ayw (71%) in sera collected from acute viral hepatitis cases, as well as from patients with chronic active hepatitis, healthy carriers and blood donors of 20 Romanian counties emphasizes the local prevalence of the ayw determinant in our country.

Acute Disease↗