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Biomedical subjects

E King

Publications and source records attributed to E King.

At least 73 records · Page 4Linked to original sources
PubMed1984

Morphologic changes in rat urothelial cells during carcinogenesis: II. Image cytometry.

Improved early detection of neoplasia by screening of urothelial cells requires an understanding of the features distinguishing normal and neoplastic cell populations. We have begun a program of study based upon a rat model system for the controlled observation of early-stage lesions produced by the carcinogen N-butyl-N-(4-hydroxybutyl)- nitrosamine. Cells dissociated directly from normal and malignant urothelium were characterized by conventional cytopathology techniques and by quantitative microscopy (for nuclear texture and nuclear and cytoplasmic size, shape, and stain content) to derive a comprehensive picture of bladder tumor development. By following the changes that occur in the dissociated urothelial cells we have found that the nuclear area, total nuclear stain, nuclear shape, and the nuclear chromatin change significantly over a 48-wk interval as the lesions progress toward malignancy.

Animals↗
PubMed1984

Endodontic treatment of a cementoblastoma.

The benign cementoblastoma (true cementoma, osteoblastoma, giant osteoid osteoma) appears to be a true neoplasm of functional cementoblasts which proliferate at the apex of teeth to form an expansile tumor. It remains intimately attached to the tooth roots and occasionally involves the root canals themselves. Although the pulpal tissue remains vital, treatment has historically consisted of extraction of the involved tooth along with extirpation of the tumor. This mode of therapy for the benign cementoblastoma should not be confused with the entity called periapical cemental dysplasia (that is cementoma, periapical osteofibroma or osteofibrosis, cementifying fibroma, localized fibro-osteoma, and periapical fibrous dysplasia). In this latter lesion the treatment consists of simply recognizing the condition and establishing a schedule for periodic evaluation of the patient. In the case presented here enucleation of the cementoblastoma and endodontic therapy were selected as treatment modalities, despite the presence of buccal and lingual expansion of the cortical plates. There has been no recurrence of this growth during the 4-year follow-up period.

Adult↗
PubMed1982

Physical therapy manpower planning. Projection models and scenarios of 1985.

Faced with the difficult task of coordinating statewide health education, the Kentucky Council on Higher Education is using several manpower projection statistics as one component of their decision-making process. These manpower data are essential when considering the establishment, expansion, continuation, or termination of health-related academic programs. Three models were used to project manpower requirements for licensed physical therapists in Kentucky. The models were 1) manpower:population ratio, 2) trend analysis based on time series, and 3) the American Physical Therapy Association's health-needs method. Four variants of the manpower:population ratio model are discussed and presented: population ratio based ona 1) national ratio, 2) Kentucky ratio, 3) weighted national ratio, and 4) weighted Kentucky radio. The trend analysis model is presented and discussed. The health-needs approach, based on expert opinion and health-related variables, identifies the quantity and quality of services required to provide the Kentucky population with the best possible care. The paper concludes with three brief scenarios describing the possible effects of the three models and physical therapy in Kentucky. The scenarios unfold from differing assumption about the effects of manpower production on health care. Scenario A is a "current arrangement" scenario. Scenario B considers the effects of predicting future manpower requirements and resources based on the past. Scenario C projects the effects of a comprehensive plan on the goal of producing the best possible care for all Kentuckians.

Forecasting↗
PubMed1980

Sex bias in psychoactive drug advertisements.

A recent concern has been the possible effect of sex-role stereotypes upon physicians' prescription patterns. In an attempt to examine the part played by drug advertisements, this paper will present a content analysis of psychoactive (mood-modifying) drug ads appearing in the American Journal of Psychiatry over a 17-year period; and a study of subjects' perceptions of the patients depicted in these drug ads across eight dimensions emerging from the content analysis. An initial perusal of psychoactive drug ads in professional medical journals suggested the existence of a sex bias: Females appeared to be presented as patients more often than males, and in a much more demeaning manner. The present analyses were done in an attempt to discover if a sex bias does exist in drug advertisements, which may influence the physician's perception of his or her patients, and subsequently, his or her prescription patterns.

Advertising↗
PubMed1976

Blood lead and erythrocyte delta-aminolevulinic acid dehydratase levels in Manchester taxi drivers.

Among 40 Manchester taxi drivers the mean blood lead was 1.10 mumol/1 (22.8 mug per 100 ml). The mean erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity among 34 of them was 30.1 units. No significant association was found between the blood lead levels and erythrocyte ALAD activity in these 34 men. No significant association was found between either blood lead elvels or erythrocyte ALAD activity and duration of service or weekly mileage as a taxi driver or with drinking or smoking habits, or age. The mean blood lead of those with homes in the north east quadrant of the city was higher than of those living elsewhere but the difference was not statistically significant. Although there was no correlation between blood lead levels and the source of domestic water, the mean blood lead of those with lead domestic plumbing was appreciably higher than the level of those with copper plumbing. There was no indication that, by virtue of their occupation, the taxi drivers were liable to greater lead absorption than their fellow-citizens.

Alcohol Drinking↗
PubMed1976

Sickness absence of lead workers and controls.

Certificated sickness rates and levels of lead exposure of 955 men who worked in a lead accumulator factory during a period of seven years (1965-72) were examined. The men were divided by department into four exposure groups; a second division into three groups was made, based on the mean of each man's blood lead measurements during the study period. Absences showed no age pattern, but men who left during the seven years of observation (ex-workers) had had a higher absence rate (842 spells/1000 man years) than those still employed in 1972 (535 spells/1000 man years). There was no significant difference in absence rates or lengths of absences between differently exposed departments either for all causes or for a selected group of potentially lead-induced causes. However, the proportion of potentially lead-induced absences was significantly higher in ex-workers (12-2%) than in current workers (7-4%). Similar analysis showed no significant differences in absence rates of men with different blood lead levels. It was concluded that higher levels of lead exposure did not seem to be associated with higher rates of absence or longer absences either for all causes of absence combined or for those causes which might be attributable to lead.

Absenteeism↗
PubMed1976

Establishment of erythropoiesis following bone marrow transplantation in a patient with congenital hypoplastic anemia (Diamond-Blackfan syndrome).

Marrow transplantation was attempted in a 13-yr-old boy with congenital hypoplastic anemia who had never responded to corticosteroid therapy. Prior to the transplant, he had received 238 transfusions, at least 12 of which were from his father. He was prepared for grafting with antilymphocyte globulin, procarbazine, and total body irradiation (1000 rads). The patient, whose red cells were Group B, then received marrow cells from his Group O, histocompatible, sister. Thereafter, reticulocytes, Group O erythrocytes, and female leukocytes appeared in the peripheral blood. Erythroid precursors were seen in the patient's marrow for the first time in his life, and all lacked fluorescent Y chromosomes. Dividing cells were all female. After initially progressing well, the patient developed interstitial pneumonia and died 55 days after the transplant. The successful erythroid graft suggested that this patient's failure to produce red blood cells was due to a defective stem cell rather than to a humoral defect, plasma inhibitor, or abnormal marrow microenvironment. It suggested further that sibling marrow may be engrafted in patients who have received multiple transfusions, even from a parent.

Adolescent↗