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Biomedical subjects

E Kerty

Publications and source records attributed to E Kerty.

52 records · Page 3Linked to original sources
PubMed1989

Regional cerebral blood flow (rCBF) and cerebral vasoreactivity in patients with retinal ischaemic symptoms.

Regional cerebral blood flow (rCBF) and cerebral vasoreactivity were assessed in 28 consecutive patients who presented with retinal ischaemic symptoms, without clinical or cerebral CT evidence of cerebral ischaemia. rCBF was measured using xenon-133 inhalation and single photon emission computed tomography before and 20 minutes after the intravenous administration of 1 g acetazolamide. The findings suggest that patients with retinal ischaemic symptoms alone due to carotid atherosclerosis often have a carotid lesion which is of haemodynamic significance with regard to cerebral perfusion and vasoreactivity. Furthermore, localized areas with reduced cerebral perfusion may also be present in some patients, without evidence of precerebral carotid occlusive disease.

Acetazolamide↗
PubMed1989

Clinical and electrophysiological abnormalities in the visual system in myotonic dystrophy.

The investigation comprised 16 patients with verified myotonic dystrophy. The patients were examined ophthalmologically, by electroretinography (ERG) and pattern visual-evoked potentials (VEPs). The results were compared to those of a normal control group. More than 50% of the patients had changes in their lenses or retinas, and the ERGs and VEPs were frequently abnormal. No statistical relation was found between the clinical and electrophysiological findings, and the pattern of abnormalities seemed to vary at random. The number of abnormal clinical and electrophysiological findings increased slightly with the age of the patients, but no statistically significant relation was found either to the patients' age or the duration of the disease.

Adolescent↗
PubMed1988

Multimodal evoked potentials, EEG and electroretinography in patients with dystrophia myotonica.

EEG, somatosensory (SEP) and visual evoked potentials (VEP) and electroretinography (ERG) were recorded from 16 patients with clinical and electromyographically verified dystrophia myotonica. The results were compared to an age- and sex- matched control group and revealed statistically significant differences between the group mean values for almost all records. Furthermore, abnormal individual electrophysiological tests were relatively frequent in the patient group. No correlation was found between abnormalities in one test compared to abnormalities in the other tests. Furthermore, no correlation was found between the number of electrophysiological abnormalities and the frequency of the disease in the nearest family. The number of abnormal electrophysiological tests increased, however, with age of the patients and duration of the disease.

Adolescent↗
PubMed1988

Amaurosis fugax: clinical, Doppler and angiographic findings.

Clinical, Doppler and angiographic findings are described in 53 consecutive patients who presented with amaurosis fugax (AF) in a total of 57 eyes; 4 had non-simultaneous attacks in both eyes. Atherosclerotic lesions were detected on Doppler or angiographic (conventional arteriography and/or intravenous digital subtraction angiography) examination in 36 (63%) of the relevant precerebral internal carotid arteries (ICA) in 34 patients. Nineteen (53%) of these lesions caused a diameter reduction of more than 75%. Patient age was the most important factor in predicting the presence of relevant carotid occlusive disease, all 36 lesions being found in patients over 50 years of age. Two unusual cases of AF are described; in one AF was caused by stenosis of the ipsilateral ophthalmic artery, and in another by occlusion of the brachiocephalic artery with a steal syndrome from the right common carotid artery (CCA) to the right subclavian artery.

Adolescent↗
PubMed1987

A subhyaloid haemorrhage as the presenting symptom of bilateral optic neuropathy.

A 28 year-old man with a spontaneous vitreous haemorrhage as the first sign of Leber's optic atrophy is presented. The blood collected in a central retrohyaloid area covering the left macula. The exact starting point of the haemorrhage was never positively identified, but it seemed to originate from an area of microangiopathy adjacent to the optic disc. For 8-10 months the vision of the left eye gradually decreased to counting fingers. A year later the visual acuity dropped to the same level on the right eye. The picture was compatible with Leber's optic atrophy. Other disorders causing bilateral optic neuropathy were excluded. A careful family history revealed several cases of visual problems for several generations. Vitreous haemorrhage as the first sign of Leber's optic atrophy has not previously been reported. Peripapillar microangiopathy, however, has been described in the asymptomatic stage of the disease.

Adult↗
PubMed1986

Visual evoked response in syphilitic optic atrophy. A case report.

A case of neurosyphilis is described. The presenting symptoms were reduced visual acuity and impaired colour vision. The examination revealed bilateral optic atrophy and acquired red-green colour defect. A syphilitic aetiology was based on positive serological tests in blood and CSF, pleocytosis and increased total protein in the CSF. The abrupt decline in visual acuity was arrested by treatment with penicillin and systemic steroids, but normalization of vision was not obtained. All VER-records, of P2 latencies and morphologies were surprisingly normal, but the amplitudes were reduced.

Color Vision Defects↗
PubMed1981

Non corneal closed eye electroretinography in healthy persons and in patients with neuronal ceroid lipofuscinosis (Stengel-Batten-Spielmeyer-Vogt disease).

Non corneal "closed eye" ERG was recorded with surface skin electrodes in 22 healthy subjects and in 7 patients with neuronal ceroid lipofuscinosis (Stengel-Batten-Spielmeyer-Vogt disease). Non corneal "closed eye" ERG was present in all normal subjects and the records comprised all the main subcomponents reported in the conventional corneal ERG. While the latencies of the a and b waves in the normal subjects differed but slightly from those reported from corneal ERGs, the amplitudes were reduced in the non corneal "closed eye" ERG. The parameters of the non corneal "closed eye" ERGs in the healthy subjects differed but slightly from those reported on non corneal "open eye" ERGs. When applied on patients with neuronal ceroid lipofuscinosis, the method proved clinically tenable and no sedation was required. The records show that ERG was absent in all but one of the patients tested.

Adolescent↗
PubMed1978

Glaucoma treatment with timolol.

Thirty-two eyes from 19 patients with either capsular glaucoma, pigmentary glaucoma or primary open angle glaucoma were given topical timolol and followed through a 3--6 months period. Twelve eyes were previously out of control on full medication including pilocarpine, epinephrine and acetazolamide. Eight of these eyes could be adequately controlled throughout the follow-up period on topical timolol or a combination of timolol and pilocarpine, but without resorting to acetazolamide. One eye needed acetazolamide in combination with timolol, and three eyes had to be referred to surgery. Twelve eyes were adequately controlled either on pilocarpine or full medication, but could be equally well controlled on timolol alone, or timolol and pilocarpine in combination. Acetazolamide could be withheld from all of the six patients who used this drug. Eight eyes were previously untreated. They could all be adequately controlled either on timolol (5 eyes) or timolol and pilocarpine (3 eyes). The study indicates that the effect of timolol 0.5% X 2 may be stronger than the combined effect of epinephrine 1% X 2 and acetazolamide 500 mg a day. Topical timolol was well tolerated. No side reactions occurred and the pupillary size and reactions were not influenced by the timolol treatment.

Administration, Topical↗
PubMedDate not supplied

Apraxia of eyelid opening: clinical features and therapy.

PURPOSE: Botulinum toxin injection is the treatment of choice in cases of benign essential blepharospasm. However, about 10% of the patients do not get sufficient effect from this treatment, and many of them have concomitant apraxia of lid opening. METHODS: Over a 3-year period we treated 12 patients. Three had pure apraxia of lid opening and in the other nine it was associated with blepharospasm. All patients were initially treated with botulinum toxin injections with poor results. They underwent surgical treatment like blepharoplasty, limited myectomy, aponeurosis repair, and/or frontalis suspension. Some of them needed post operative botulinum toxin injections in the pretarsal part of orbicularis oculi muscles. RESULTS: This combined therapy gave good functional and aesthetic results. CONCLUSIONS: The specific causes of blepharospasm and apraxia of lid opening are unknown, but these two conditions coexist in some patients and can be difficult to treat. It is important to make a correct diagnosis, and a combined surgical and botulinum toxin treatment can be very effective.

Aged↗
PubMedDate not supplied

Intracranial primary leiomyosarcoma arising in a teratoma of the pineal area.

The case of a 33-year-old man with a primary leiomyosarcoma arising in a mature teratoma in the pineal area is presented. The tumor extended into the posterior part of the third ventricle and caused hydrocephalus. Its smooth muscle derivation was confirmed by immunohistochemistry and electron microscopy. The patient has been followed for more than 2 years after surgery and postoperative radiotherapy. He has full working capacity and there are no signs of tumor recurrence. To our knowledge this is the first presentation of a leiomyosarcoma derived from a teratoma in the pineal area.

Adult↗