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Biomedical subjects

E Keller

Publications and source records attributed to E Keller.

At least 361 records · Page 20Linked to original sources
PubMed1979

Studies with clonidine (dixarit) in menopausal women.

Eleven women with menopausal symptoms were treated with 150 micrograms Clonidine (dixarit) daily. Before and during therapy, plasma estradiol-17 beta, LH, FSH and prolactin levels were measured by specific radio-immunoassays. In addition, each patient recorded the number of hot flushes a day and symptoms were monitored by the Kupperman-index. A highly significant fall in the number of hot flushes by day and night occurred during therapy (p less than 0.001) and the Kupperman-index similarly improved. Significant pulse and blood pressure changes were not noted and plasma hormone concentrations remained unaltered. Medication was well tolerated. Clonidine therapy would appear to be the treatment of choice for menopausal symptoms if estrogens are contraindicated.

Adult↗
PubMed1979

Cerebral potentials preceding unilateral and simultaneous bilateral finger movements.

Cerebral potentials preceding voluntary bilateral simultaneous finger movements were investigated in 19 right-handed young adult subjects, and were compared with unilateral right-sided finger m n the same experiment. With bilateral movements, the Bereitschaftspotential (BP) was not symmetrical or larger over the dominant hemisphere, but surprisingly, it was larger over the minor hemisphere. The BP averaged -3.66 microV (S.D. 1.96) over the left precentral region and -4.82 microV (S.D. 3.73) over the right precentral region in this condition. The difference was significant at 2P less than 0.01. This difference was pronounced in precentral leads but very small and almost missing in parietal leads. The pre-motion positivity (PMP) was well developed and even larger with bilateral than with unilateral (right-sides) movements. At the vertex it averaged +1.33 microV (S.D.4.16) with bilateral movements and only +0.15 microV (S.D. 1.42) with right-sided unilateral movements (2P less than 0.05). With bilateral movements the PMP could be observed in any record, but with unilateral movements it was missing at the left precentral lead, in accordance with previous publications (Deecke et al. 1969, 1976). The motor potential (MP), measured in a bipolar record from left and right precentral leads, was larger with unilateral (-1.25 microV, S.D. 1.33) than with bilateral movements (-0.36 microV, S.D. 0.92). Onset time differences of the BP preceding unilateral and bilateral movements were very small. However, there was a tendency towards earlier onset with unilateral than with bilateral movements (1031 msec, S.D. 358, as compared with 951 msec, S.D. 305). The averaged EMG revealed differences in movement onset. Muscular contraction tended to be earlier in the right than in the left m. flexor indicis in our right-handed subjects, on the average by 16 msec (S.D. 15). With unilateral right-sided movements, the left m. flexor indicis was not silent but showed an abortive mirror activity in the EMG, without visible movement. This activity occurred on the average 50 msec (S.D. 39) later on the non-moving side.

Adult↗
PubMed1979

[Severe complications after caval vein catheterization (author's transl)].

In 13 autopsy cases after catheterization of the superior caval vein a surprisingly high rate of incorrect positions of the catheter tip within the right atrium was seen. This had resulted in wide spreaded lesions of the endocardium and in voluminous thrombosis around the catheter tip. In one case a pericardial serous effusion with letal cardiac tamponade was found because of such malpositioning of a caval catheter. The mechanical stress to the endothelium by the catheter tip is held responsible for the intima lesions in the right atrium. The need for X-ray-control of the catheter position and its fixation at the site of entry through the skin is stressed.

Aged↗
PubMed1978

Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus.

Evidence from studies involving release, postsynaptic responses, inactivation, storage and synthesis etc. support the contention that glutamate may be the transmitter of the perforant input to the granule cells in the dentate gyrus of the hippocampus. In the present report the release of endogenous glutamate and the levels of reduced pyridine nucleotides (NAD(P)H) has been measured in parallel experiments on slices from the dentate gyrus of the hippocampus. A Ca-dependent release of glutamate is evoked by tissue depolarization caused either with electrical field stimulation or with elevated KC1. Electrical stimulation induced a transient increase in tissue NAD(P)H levels, the increase being inhibited by approximately 50% during Ca-free conditions. KC1 stimulation, on the other hand, produced a long-lasting decrease in NAD(P)H, the decrease being halved in the absense of Ca. A metabolic relation between stimulus secretion and energy utilization is discussed.

Animals↗
PubMed1978

Intrauterine development, feto-placental function and pregnancy outcome after induction of ovulation with bromoergocryptine.

18 pregnancies occurred after treatment with bromoergocryptine in 17 patients who wished to conceive, but who suffered from anovulation of varying aetiology. The course of 15 pregnancies was uneventful. Three pregnancies ended in abortion. Nine of the 17 women had hyperprolactinemic amenorrhea. Furthermore, one woman had normoprolactinemic post-pill amenorrhea, another normoprolactinemic anovulatory oligomenorrhea and a third normoprolactinemic anovulatory regular menstruations. With the exception of one woman, all had galactorrhea. The courses of pregnancy were monitored by frequent ultrasound measurements of the fetal biparietal diameter, maternal urinary estriol excretion and radioimmunological measurements of plasma estrone, estradiol, unconjugated and immunoreactive estriol, progesterone, and HPL. All data were within the normal ranges and all babies were healthy at birth and had no teratogenic defects. The data prove the great value of bromoergocryptine in the treatment of hyperprolactinemic anovulation, sometimes even in the treatment of normoprolactinemic anovulation. Moreover, the results indicate no adverse effect on either the course or the outcome of pregnancy.

Abortion, Spontaneous↗
PubMed1978

Therapy of androgenetic sympatomatology with cyproterone acetate and ethinyl estradiol.

The effectiveness of therapy with cyproterone acetate and ethinyl estradiol was studied in 103 women. Acne and seborrhea responded best with 91.7 and 93.3% respectively, including complete and partial therapeutic success. For hirsutism complete remission and partial improvement were found in 75.3% of the treated women. Under therapy, body weight did not change in 51.9%, while 24.7% of the patients gained weight and 23.4% lost weight. The cycle length remained normal after therapy in 35.8%. Normalization or improvement was found in 54.7%. In 6.3% no improvement was noted after therapy and in 3.2% cycle irregularity developed in women with previous undisturbed pattern. According to BBT, improvement of the functional capacity of the reproductive system was found in 32.9% of the patients. Only 3% of the women studied demonstrated a deterioration. The 17-ketosteroid excretion was diminished in 35.3% after therapy and remained unchanged in 64.7%. The therapeutic regimen used for the study was well tolerated and good cycle control was obtained.

17-Ketosteroids↗
PubMed1978

Postnatal development of rats born preterm and postterm. I. Body weight.

Litters with 3 preterm, 3 term and 3 postterm littermates have been fed by one mother each. Fetal body weight continues to increase in utero if the normal gestational period is extended by 1 day. But this intrauterine weight gain is smaller than the postnatal weight gains of term rats of the same conceptional ages. While the body weights of term and postterm rats increase rapidly immediately after birth, there is a lag phase of 3 days in preterm animals. This delay in weight gain is not caught up during a period of 30 postnatal days. This appears to be due to malnutrition in the early postnatal period. After the 20th day of life, the weight gain markedly increases in all groups, indicating the effect of supplemental feeding in the weaning period.

Animal Nutritional Physiological Phenomena↗
PubMed1978

The postnatal development of rats born preterm and postterm. II. Liver, brain, heart and kidneys.

Groups of 3 preterm (duration of gestation 22 days), 3 term (23 days), and 3 postterm (24 days) rats have been fed together by 1 mother rat. The postnatal growth of liver, brain, heart and kidney has been studied up to the 30th day of life. The postnatal loss of water shows good correlation with the maturation of each organ. The postnatal loss of water is marked in brain and kidneys, but only slight in liver and heart. The pronounced growth spurt of the brain at the about 10th day of life is probably due to the opening of the eyes. The growth spurt of the liver at the 15th day may be due to the supplementary food at the time of weaning. The effect of intrauterine undernutrition in postterm rats is most strikingly demonstrated in the liver. Postnatal undernutrition in preterm rats causes a retardation of growth of the liver and kidneys.

Animals↗
PubMed1978

Dose-response study with a new LH-RH analogue, D-Ser (TBU)6 LH-RH 1-9 (EA)10 during the follicular phase of the menstrual cycle.

D-Ser (TBU)6 LH-RH 1-9 (EA)10 (HOE 766) a highly active LH-RH analogue, was studied with regard to its effects on the release of follicle stimulating hormone (FSH), luteinizing hormone (LH) and oestradiol-17beta (Oe2) during the follicular phase of the menstrual cycle. Forty-two regularly menstruating women were allowed to five different treatment groups with different doses (1.25 microgram; 2.5 microgram; 5.0 microgram; 10.0 microgram; 20.0 microgram) of HOE 766 given as intravenous bolus injections and the plasma concentrations of FSH, LH and Oe2 were measured up to 24 h after injection using specific radioimmunoassays. In the majority of cases, peak values of both FSH and LH occurred 4 h after injection being significantly different from pre-injection levels (P less than 0.02 in the 1.25 microgram treatment group, P less than 0.005 for the other treatment groups). Statistical analysis of maximum values as well as the absolute and relative increase in the different treatment groups revealed a dose-dependent effect of HOE 766. Maximum values of Oe2 occurred 8 h after injection and were found to be significantly different from pre-injection levels (P less than 0.005). However, no dose dependent effect was observed. It was concluded that HOE 766 is a potent and long-acting stimulator of FSH, LH and OE2 release in women. The effect of HOE 766 is dose dependent for FSH and LH but not for Oe2.

Adult↗
PubMed1978

[Therapeutic problems in the "short-bowel-syndrome" (author's transl)].

The authors report on 6 children with short-bowel-syndrome. The expectancy of life of the patients depends on the mucosal surface of the residual intestine and on the degree of adaption. After removal of larger proportions of the intestine, nutrition should be started parenterally and followed by an early but cautious oral feeding. The administration must be distributed continuously over the day. At first carbohydrates are given as monosaccharides, fats as M. C. T. and proteins as amino acid mixtures. Carrot soup has proved useful as a water-binding substance for the improvement of stool consistency. An anabolic condition of the metabolism should be maintained. Therapy with cholestyramin is indicated in chologenic diarrhoea. Substitution of vitamins, especially vitamin B12 is very important after resection of the ileum.

Amino Acids↗