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E Karg

Publications and source records attributed to E Karg.

43 records · Page 3Linked to original sources
PubMed1986

[Recurrent disseminated infundibulofolliculitis].

A white male patient with disseminated, pruritic, follicular papules on the skin is reported. Histologically, an inflammatory infiltration around the infundibulum, perifollicular oedema and spongiosis of the follicular epithelium were demonstrated. The lesions failed to respond to therapy. On the basis of the clinical and histological findings, we suggest that this is a case of disseminated and recurrent infundibulofolliculitis, which was first described by Hitch and Lund in 1968.

Folliculitis↗
PubMed1985

Old man.

Explore the source record for details and available documents.

Aged↗
PubMedDate not supplied

Melanin-related biochemistry of IGR 1 human melanoma cells.

Cultured melanoma cells have been of great value in the study of pigment metabolism. IGR 1 human melanoma cells, established by Dr Christian Aubert, produce melanin in large quantities. These cells have been used for isolation of human tyrosinase which enzyme has not previously been obtained in a pure form. IGR 1 cells contain large amounts of 5-S-cysteinyldopa which is the quantitatively most important catecholic amino acid. This review deals with the metabolism of dopa, cysteinyldopa, glutathionyldopa, cysteine and glutathione, compounds of central importance in pigment metabolism. The information available on tyrosinase, catecholic compounds and on thiols in IGR 1 melanoma cells makes these cells most suitable for further investigation of the metabolism of human melanoma cells.

3,4-Dihydroxyphenylacetic Acid↗
PubMedDate not supplied

Alteration of glutathione level in human melanoma cells: effect of N-acetyl-L-cysteine and its analogues.

The effects of N-acetyl-L-cysteine (L-NAC), N,N-diacetyl-L-cystine (oxidized form of L-NAC) and N-acetyl-D-cysteine on the intracellular glutathione (GSH) level and their toxicity were investigated in the human melanoma cell culture IGR1. L-NAC applied in 3 mM concentration for 24 hr decreased; when applied for 48 hr it did not alter the intracellular GSH level. Treatment with 1 mM L-NAC for 24 hr had no effect on cellular glutathione, whereas the same concentration applied for 48 hr resulted in an increase in the level of GSH. Both concentrations also induced cell injury as determined by protein assay and trypan blue staining. N,N-diacetyl-L-cystine (0.5 and 1.5 mM, 24 hr) induced a decrease in cellular glutathione content without any apparent cell toxicity. D-NAC (1 and 3 mM, 24 hr) did not influence the GSH level of the melanoma cells; however, it had toxic effects resulting in cell loss.

Acetylcysteine↗