Search PubMed⌕ Search

Biomedical subjects

E K Smith

Publications and source records attributed to E K Smith.

At least 55 records · Page 3Linked to original sources
PubMed1980

Long-term lithium treatment and the kidney. Interim report on fifty patients.

This is a report on the first part of our study of the effects of long-term lithium treatment on the kidney. Creatinine clearance, maximum urinary osmolality and 24 hour urine volume have been tested in 50 affectively ill patients who have been on long-term lithium for more than one year. These findings have been compared with norms and with values of the same tests from screening prior to lithium, available for most of our patients. No evidence was found for any reduction of glomerular filtration during lithium treatment. Low clearance values found in several patients could be accounted for by their age and their pre-lithium values. Urinary concentration defect appeared frequent but the extent of the impairment is difficult to assess because of the uncertainty about the norms applicable to this group of patients. The concentration defect appeared reversible, at least in part. Polyuria above 3 litres/24 hours was found in 10% of patients. An attempt is made to draw practical conclusions from the preliminary findings.

Adult↗
PubMed1979

Myocardial tissue concentrations of magnesium and potassium in men dying suddenly from ischemic heart disease.

Optimum tissue levels of magnesium and potassium ions are essential to the structure and function of the myocardium. We hypothesized that an inapparent deficiency of one or both of these elements might contribute to sudden cardiac death in a susceptible person, and in this study investigated levels of these elements in the myocardium of men experiencing sudden death to determine if there was such an association. Subjects dying suddenly with ischemic heart disease had significantly lower levels of myocardial tissue magnesium and potassium than the controls (men dying of acute trauma). The four lowest potassium values were obtained for the only men in the group with a history of angina (P less than 0.0005). Three of the men with angina also had the lowest tissue magnesium levels (P less than 0.005). The intriguing finding gives support to the hypothesis.

Angina Pectoris↗
PubMed1978

Hypertension and unilateral vascular occlusion. Diagnosis and surgical intervention.

Four hypertensive patients with unilateral atheromatous renal arterial occlusion have been studied. Each showed elevation of renal venous activity on the side of the vascular occlusion relative to the opposite side. Three of the patients underwent nephrectomy with amelioration of their hypertension. It is concluded that surgical treatment is valid therapy in patients with atheromatous unilateral renal vascular occlusion and ipsilateral elevation of renal venous renin activity.

Aged↗
PubMed1978

Imaging of canine tumors with 11C-methylputrescine.

The polyamines--putrescine, spermidine and spermine--are present in elevated concentrations in rapidly growing cell lines and in several neoplasms. Five dogs with benign or malignant tumors and one normal dog were imaged with a rectilinear scanner following I.V. administration of 2--8 mCi 11C-methylputrescine. High concentrations of 11C-methylputrescine were found in the liver, and in the kidneys and urine in the dogs with good renal function. Concentrations were higher in tumors than in skeletal muscle, blood or lung. The tumor/blood ratio varied from 2--21; tumors were demonstrated by imaging in four dogs in which the ratio exceeded 4.0. 11C-methylputrescine is a possible tumor imaging agent.

Animals↗
PubMed1976

Results and costs of investigating newly detected hypertensive patients.

1. Eighty unselected hypertensive subjects were investigated at a cost of $78.00 per patient, in a short out-patient study programme. Seven (9%) were found to have a cause for their hypertension; incidental abnormalities were found in twenty-two (28%). 2. The combination of clinical selection and planned out-patient investigation should detect all patients with secondary hypertension.

Adult↗
PubMed1976

Comparison of metoprolol and propranolol in modification of haemodynamic and renin-aldosterone responses to tilting in humans.

1. Acute oral administration of metoprolol and propranolol to ten normal males resulted in equal reduction in heart rate both supine and after passive tilting to 60 degrees. 2. Tilted systolic blood pressure was reduced by both agents but metoprolol alone reduced supine systolic blood pressure. 3. Tilted but not supine diastolic blood pressure was reduced by both agents. 4. Metoprolol and propranolol both reduced the rise in plasma renin activity induced by tilting. 5. No effect of tilting was observed on plasma aldosterone.

Adult↗
PubMed1975

Carpal tunnel syndrome: a complication of arteriovenous fistula in hemodialysis patients.

Symptoms of compression of the median nerve in the carpal tunnel developed in two patients in whom an arteriovenous fistula was created to alleviate chronic renal failure through hemodialysis. Anatomic changes in the wrist area due to the fistula are probably important in the development of this syndrome, and pre-existing uremic peripheral polyneuropathy may also be important in the early development of local symptoms of nerve damage.

Arteriovenous Shunt, Surgical↗
PubMed1975

Changes of sodium transport in erythrocytes of the maturing rabbit.

The red blood cells of New Zealand white rabbits have a low sodium and high potassium content. As the animals mature, the sodium concentration rises and the potassium content falls; studies of red cells from a group of five young and five mature animals revealed a highly significant increase of cell sodium with age that was associated with a significant fall in the rate of ouabain-inhibited active sodium efflux. This difference was still seen when the sodium concentration within the cells from old and young animals was equalized and elevated to saturating levels for active pump efflux. Total sodium efflux, however, increased significantly with age as did total sodium influx so that a steady state was reached. Ouabain-sensitive ATPase activity fell significantly in the cell membranes from older animals and ouabain-insensitive ATPase increased with age. The survival time of 51Cr-labeled red cells was significantly longer in old than in young animals and it is concluded that as the rabbit matures its red cells survive for a longer period and this is associated with the changes of sodium transport and ATPase activity that have been documented.

Adenosine Triphosphatases↗
PubMed1974

Acute renal failure in multiple myeloma.

Two cases of acute renal failure complicating multiple myeloma are reported. In both, the renal failure preceded the diagnosis of multiple myeloma. In one case oliguria occurred after performance of a venogram; renal function returned to normal after two weeks of intermittent peritoneal dialysis, emphasizing the reversibility of the renal failure in some cases.

Acute Kidney Injury↗