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Biomedical subjects

E K Edwards

Publications and source records attributed to E K Edwards.

35 records · Page 2Linked to original sources
PubMed1983

Psoriasis therapy. The effect of UV radiation on sensitization to mechlorethamine.

A study was performed to determine the effect of UV-B radiation on the sensitization of patients to topically applied mechlorethamine hydrochloride. Patients with widespread psoriasis were randomized into two groups. One group was given six daily treatments of one minimal erythemal dose (MErD) prior to starting daily applications of a 0.02% mechlorethamine ointment and, thereafter, one MErD weekly; the other group was given daily applications of mechlorethamine but received no UV-B. The improvement of psoriasis was monitored by a severity score system and patients were treated for 30 days, or until contact dermatitis occurred. The addition of UV-B to topical applications of mechlorethamine reduced the incidence of allergic contact dermatitis to mechlorethamine from 64% to 22%. In those sensitized to mechlorethamine, the time required for sensitization to develop was increased from 14 to 23 days by UV-B therapy.

Administration, Topical↗
PubMed1983

The effect of antihistamines on ultraviolet-light-induced erythema.

Because of the possible role of histamine as an early mediator of ultraviolet light induced erythema, we studied a group of volunteers treated with both H1 and H2 blockers, alone and in combination, before and at various time intervals after, UVL irradiation. No difference was found in the degree of erythema produced by any of the antihistamines used, whether alone or in combination, when compared with the saline control.

Erythema↗
PubMed1982

Reduction of the erythema response to ultraviolet light by nonsteroidal antiinflammatory agents.

The effect of three nonsteroidal antiinflammatory agents (NSAIA) on ultraviolet B (UV-B)-induced erythema was studied in normal human volunteers. Aspirin, indomethacin, and ibuprofen were administered orally 2 h before exposure to UV-B from fluorescent sunlamps and at 4-h intervals for a total of four doses. The minimal dose of light to produce erythema (MED) was determined for each subject with and without drugs. There was a 240% increase in the mean MED when the NSAIA were given. NSAIA, given orally, can increase the threshold for UV-B-induced erythema when administered near the time of irradiation.

Anti-Inflammatory Agents↗
PubMed1981

Ozone production by dermatologic phototherapy equipment.

Phototherapy is an extremely effective and popular physical modality used by many dermatologists to treat a wide variety of cutaneous disorders. The major dermatologic journals frequently have articles on new applications for phototherapy. The science of photobiology has advanced rapidly over the last ten years and probably will continue to do so. One fact that should be kept in mind when using an ultraviolet light apparatus is the possibility of the generation of ozone, a toxic gas. In this study, a number of devices commonly used by many dermatologists in phototherapy were monitored for ozone production. Although some of the equipment examined can produce ozone, it is produced at very low levels, dissipates quickly, and poses no health threat.

Dermatology↗
PubMed1981

Contact urticaria to cow's milk.

Contact urticaria developed in a child as a reaction to cow's milk. After heating the milk to 80 degrees C for thirty seconds, the child did not have a similar reaction. To my knowledge, this is the first case of contact urticaria to cow's milk in which there were no systemic manifestations of allergy.

Animals↗
PubMedDate not supplied

Grenz ray therapy.

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Carcinoma, Squamous Cell↗