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Biomedical subjects

E Justrabo

Publications and source records attributed to E Justrabo.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Immunocytologic study of light cell lines established in vitro from Ewing's sarcoma. Identification of neural markers].

Using immunocytological techniques, neuroectodermal markers were identified on Ewing's sarcoma cell lines established in vitro and carrying the chromosomal translocation t(11;22). Eight cell lines were tested using a panel of monoclonal antibodies. The presence of cell surface antigens recognized by HNK-1 antibody was confirmed. The cells showed also positive reactions using antibodies directed against Neuron-Specific-Enolase and neurofilament proteins. The presence of these neural markers in the Ewing's sarcoma cells tested is an additional argument substantiating the putative neural origin of this tumor.

Animals↗
PubMed1988

Immunohistological characterization of a Ewing's sarcoma case.

The histogenesis of Ewing's sarcoma (ES) remains uncertain. Mesenchymal and neuroectodermal origins were the most recent hypotheses. In an attempt to test these two hypotheses, frozen sections of an ES with the chromosomal translocation t(11;22) have been studied using a panel of antibodies directed against monocytes/macrophages cell surface antigens (Leu M1, Leu M2, Leu M3, and MO1), and against neural components (NSE, S-100, T4, and HNK-1). None of these antigens were detected. Positive reactions were obtained with antibodies recognizing HLA II antigen and B2-microglobulin. From a panel of various intermediate filaments only vimentin was shown to be present. None of the two hypotheses could be supported by the results obtained from the immunohistological analysis of the tumor studied. In the absence of a specific immunological pattern, the chromosomal t(11;22)(q24;q12) marker remains the only diagnostic criterion of ES.

Antibodies, Monoclonal↗
PubMed1987

[Glandulo-cystic polyps of the stomach. Apropos of 12 cases and review of the literature].

We report 12 cases of cystic glandular fundic polyps detected in 7 women and 5 men. As in the 238 similar previously reported cases these lesions were always located in the fundic gastric mucosae and did not involve the muscularis mucosae. They were discovered by endoscopy in patients with minor abdominal discomfort. They were less than 5 mm in diameter and were more often multiple and sessile; only a few of them were pedunculate. They consisted of mucosal cysts lined with cuboidal, parietal or chief cells and surrounded with a normal lamina propria. If in 213 cases, these polyps were not associated with polyposis coli in 37 cases they occurred with a Gardner's syndrome or a familial adenomatosis coli. These benign lesions are without malignant potential. Careful gastroscopic follow up with biopsy is recommended for all patients with multiple gastric polyps. The etio-pathogenesis of these polyps is still unknown. Their relationship to familial polyposis coli or to Gardner's syndrome is obscure.

Adenomatous Polyposis Coli↗
PubMed1987

[Gastric teratoma disclosed by neonatal digestive hemorrhage].

A gastric teratoma diagnosed after a gastro-intestinal tract bleeding in a neonate is reported. The endogastric tumor was shown by gastric endoscopy. The tumor was pediculated and a simple tumorectomy was performed, without trouble later. Fifty-three other cases have been found in the literature. Most of them presented with abdominal distension and a palpable mass; diagnosis was always made after surgery and the diagnosis of mature gastric teratoma was confirmed by histological examination. These rare tumors are always of benign nature, but are often revealed by complications. Their frequency is less than 1% of infants teratoma and 85% are found in the first year of life; they are more frequent in males.

Gastrointestinal Hemorrhage↗
PubMed1986

[Acute granulomatous interstitial nephritis and hepatitis caused by drugs. Possible role of an allopurinol-furosemide combination].

Acute granulomatous interstitial nephritis and acute granulomatous hepatitis were simultaneously observed in the same patient. Clinical and anamnestic arguments suggest that allopurinol could be responsible for this double localization, but a possible part played by furosemide cannot be excluded. The patient spontaneously recovered without corticosteroid therapy. Such an acute drug induced association did not have been proved so far.

Acute Disease↗
PubMed1985

Gastric carcinoma in Côte d'Or (France). A population-based study.

The registry of digestive cancer in the Department of Cote d'Or, France, recorded newly diagnosed cases of gastric cancer between 1976 and 1980. The annual incidence rate, adjusted to the world population, was 15.2/100,000 for men and 6.1/100,000 for women. Stomach cancer incidence showed a substantial decline during the 5 yr of the study and this decline was more pronounced in men than in women. The operability rate was 62.4% and the resectability rate was 40.2%. Operative mortality after curative surgery was 17.6%. For all subjects, 17.6%, 29.1%, and 26.0% had localized, regional, and distant disease, respectively. The remaining 27.3%, not operated upon, with no evidence of metastases, had unclassifiable disease. The overall 5-yr corrected survival rate was 16.5%. In the absence of curative surgery all patients died in the 4 yr after diagnosis. After curative surgery the 5-yr corrected survival rate (excluding operative mortality) was 42.8%. The most important determinant of the survival was the pathological stage of the tumor. The age-corrected 5-yr survival was 98.7% for cases limited to the digestive wall, 45.5% for cases involving the serosa, and 26.6% for cases with locoregional extension. These results support the fact that, although declining, gastric cancer remains relatively frequent. Its overall prognosis in a well-defined population, where cases limited to the digestive wall are rare, remains poor.

Actuarial Analysis↗
PubMed1985

Fatty acid composition of human heart phospholipids: data from 53 biopsy specimens.

Fatty acid composition of human heart phospholipids was determined in 53 specimens of left ventricular myocardium collected during mitral valve replacement. Ages of the subjects (29 males and 24 females) ranged from 14 to 75 years (mean age = 54). Samples were immediately placed in chloroform-methanol 2/1, v/v to which antioxidant was added. Extracted phospholipids were converted to methyl esters which were analyzed by gas liquid chromatography on glass capillary columns. Morphological examination was also performed on 35 out of 53 samples. Age of the patients as well as the morphological state of the organ had no significant effect on major fatty acids in heart phospholipids. No difference by sex was detected. Trans-octadecenoic isomers were detected in all samples but they remained at a low level (0.4% to 1.2% of the total fatty acids).

Adolescent↗
PubMed1985

[Trisomy 18 and prune belly syndrome].

Ultrasonic examination in a thirty five years old woman about to undergo midtrimester amniocentesis suggested an intra abdominal fetal mass. The mass was a grossly distended urinary bladder. The pregnancy was terminated at 20 weeks. Necropsy was confirmative for a prune-belly syndrome. Chromosomal analysis demonstrated a 47 XY + 18 karyotype.

Adult↗