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Biomedical subjects

E Jones

Publications and source records attributed to E Jones.

334 records · Page 19Linked to original sources
PubMedDate not supplied

Deaf and hearing children's conceptions of the body interior.

PURPOSE: To determine if deaf and hearing children differ in their conceptions of the body interior and to examine children's conceptions of their internal bodies at three different age stages. METHOD: Eighty deaf children and 190 hearing children ages 5 to 15 years were grouped by age to reflect preoperation, concrete operation, and formal operation stages of cognitive development. The Goodenough-Harris Draw-A-Person and Inside-the-Body Test were administered. Results were analyzed by ANOVA. RESULTS: Deaf children in each of the three groups knew significantly fewer body parts than the hearing children. Adolescents knew significantly more about their body interiors than did the younger age groups. CONCLUSION: Results of this study lend empirical support to Crider's (1981) development theory of how conceptions of the body interior develop.

Adolescent↗
PubMedDate not supplied

A time series study of the effectiveness and costs of EPSDT outreach in Maine.

Maine's Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) program provides outreach and case management services through written agreements with 13 community-based agencies. These agencies are reimbursed on a cost-related basis for contacting new and re-eligible Medicaid families to inform them about EPSDT services and to enroll children in the program. Since October 1979, local agency outreach workers have attempted to inform 95 percent of the eligible families in their own homes. Effectiveness was measured by comparing the percentages of families informed with the 95 percent Federal requirement. Concurrently, but separately, agency costs were monitored. The authors undertook a study to determine the unit costs of informing families for 4 years and to relate those costs to the percentages of families informed. Using a single group time series design combined with a cost-effectiveness model, both effectiveness and efficiency were examined. The percentage of families informed increased 7.8 percent from State Fiscal Year (SFY) 1980 through SFY 84. The percent of increase per year, however, has decreased from 3.42 percent to 1.29 percent. The statewide informing unit cost decreased from $51.19 to $45.34 during the same time period. Examination of individual agency unit costs indicates that the difference between the lowest and highest agency unit cost is becoming greater each year. This study has reaffirmed the authors' belief that personal contact with families increases the likelihood of enrolling children in the program; less than 3 percent of the families informed of EPSDT services declined them. The study also indicates that changes in program procedures, reimbursement, or both, are needed to increase further the effectiveness and efficiency of this aspect of the program.

Child↗
PubMedDate not supplied

Experimental evaluation of nonspecific immunostimulation and chemotherapy in the intracranial tumor-bearing Fisher rat.

One hundred sixty rats bearing intracranial tumors were divided into groups of 10 to evaluate C-I interval +, effect of chemotherapy alone (BCNU), chemotherapy and C. parvum, and C. parvum alone in the rat tumor model. All therapy was administered intraperitoneally: BCNU -5.2 mg/kg (40% of LD10) on the 9th and 16th post tumor implant day, and C. parvum-1.4 mg regardless of the body weight and the 6th or 23rd day and 6th and 23rd post tumor implant day. An additional group received BCNU on the 9th and 16th day and C. parvum every 3rd day beginning with the 11th post implant day. It is concluded that C. parvum given before BCNU yields the greatest increase in survival in this animal system. Two or more injections were detrimental and injections after BCNU were of less value. C. parvum alone was minimally effective. If nonspecific immunostimulation is contemplated in this animal tumor system, it would appear to be best given before chemotherapy. This may relate to the brain as a "privileged immune site", or a peculiarity of the blood brain barrier in an intracranial lesion as it related to combined therapy.

Animals↗
PubMedDate not supplied

Thrombosis and coagulation abnormalities associated with cancer.

Abnormalities of hemostasis and malignancy have been recognized since the 19th century. Thrombosis and hypercoagulability are reported in as many as 60 percent of patients with malignancies. Decreased levels of protein coagulation factors, circulating anticoagulants and platelet numbers, and function changes are reported. The purpose of this work is to report a case of portal thrombosis in a patient with a myeloproliferative disorder and to review protein coagulation and platelet abnormalities associated with malignancies. The clinical laboratory assessment of these abnormalities is reviewed. The patient was a 59-year-old woman who was referred to the Vanderbilt University Medical Center with a diagnosis of septic portal vein thrombosis. After evaluation, it turned out that she had a myeloproliferative disorder and portal vein thrombosis secondary to that. Hypercoagulative states have been reported with a variety of carcinomas and other neoplasms. They may or may not be associated with acquired or genetic deficiencies of antithrombin III, protein C and/or S. Factors I, V, VIII:C, IX, and XI have all been reported as being elevated and implicated in hypercoagulability in patients with neoplasms. Increased platelet turnover and decreased survival have been noted in patients with disseminated tumors. Thromboses with lysis of the thrombus may be monitored by increased levels of fibrin degradation products, D-dimer, fibrinopeptides A and B, and platelet factor IV among others. There are frequently decreases in coagulation inhibitors including antithrombin III, protein C and protein S. These changes lead to a state of low-grade disseminated intravascular coagulopathy where thrombus formation is a more frequent occurrence than is hemorrhage.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Coagulation Disorders↗