[Clinical and neuropathological pictures of cerebral palsy with choreoathetosis].
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Biomedical subjects
Publications and source records attributed to E Jankowicz.
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The results of EMG investigations with pharmacological and functional tests are reported in a rare case of periodic muscular rigidity with spontaneous activity at rest mainly in shouldergirdle muscle. The aetiology of the syndrome is unknown.
The authors present a clinical description of three cases of occlusion of the left posterior cerebral artery. The pathogenesis of the syndrome of alexia without agraphia is discussed, together with other coexistent symptoms and signs such as hemianopsia, colour anomia, disturbances of recent memory. The discussion is based on own observations and a review of the pertinent literature.
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In 70 cases of ischaemic brain strokes and 25 cases serving as a reference group the levels of immunoglobulin A, M, G were determined in the cerebrospinal fluid. The obtained results demonstrated that in the studied group the mean levels of IgA and IgM and total protein were increased in the cerebrospinal fluid. The value of IgG was unchanged in relation to the control group. The rise in the mean levels of IgA and IgM was not always parallel with the rise in the total protein level. The authors discuss the importance of blood-brain barrier. Its role seems plausible in cases with raised levels of immunoglobulins and total protein. These changes in the levels of immunoglobulins can be a result of various concomitant local and systemic factors.
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The authors presented the case of a 32-year-old male patient with a 22-year history of chronic inflammatory demyelinating polyradiculoneuropathy. They paid attention to the number of recurrences and the effects of corticosteroid therapy. They also emphasized that only the peripheral nervous system was affected.
In the analysed material of 248 children with past craniocerebral trauma epilepsy developed in 25 cases (10%). In the group of post-traumatic epilepsy seizures developed twice as frequently after severe trauma than after light trauma. In EEG investigations in the group with light trauma the observed changes included slowing down of background activity, focal changes or lateralization as the only finding. In the group of severe trauma the EEG changes included slowing down of background activity with associated lateralization or focal changes. In the group of children with epilepsy following severe trauma the same changes were found in EEG curves prior to development of seizures. The authors believe that changes of this type may predict manifestation of epilepsy and may be regarded as sufficient for prophylactic treatment with anticonvulsants.
Headache with paroxysmal vertigo were induced by cough in a case of the Arnold-Chiari type I malformation. The authors suggest that exertional headache and posterior cranial fossa symptoms of unclear aetiology may indicate presence of the syndrome, and the availability of magnetic resonance imaging made possible the detection of the malformation.
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Subcortical dementia is a clinical syndrome incorporating disorders of cognitive and affective sphere, which is caused by organic damage to subcortical structures. The syndrome is usually connected with Progressive Supranuclear Palsy, Huntington Disease, Parkinson's Disease. Subcortical dementia is mainly characterized by: slowing down of psychic functions and impairment of their precision, disorders in the ability to use achieved knowledge and personality changes. Most authors stress the fact that similar cognitive and emotional personality defects are observed in cases of frontal cortex damage. Recent research points to the existence of functional subcortical-prefrontal circuits which regulate human behaviour. There is a link between subcortical dementia and functional or structural break of one or more cortical-subcortical connections. Attention is also called to disorders in certain neurotransmitting systems (dopaminergic, acetylcholinergic) as well as to brain hypometabolism in basal ganglia, thalamus and prefrontal cortex.
Artery dissection means tearing apart of its layers by blood coming inside after endothelial damage. The authors describe the prevalence of that pathology of carotid, arteries (diagnosed rarely so far), pointing to early onset age and to its multifactorial aetiology and pathogenesis. They also outline the pathomechanism of the neurological symptoms and emphasize the variety of the clinical manifestations. The diagnostic possibilities of artery dissection are also presented.