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Biomedical subjects

E Jacobsen

Publications and source records attributed to E Jacobsen.

At least 145 records · Page 8Linked to original sources
PubMed1977

Postoperative ventilatory response to carbon dioxide following neurolept anaesthesia.

In order to investigate the duration of respiratory depression following neurolept anaesthesia, 21 patients who had hemilaminectomia performed were subjected to ventilation-carbon dioxide response tests by a rebreathing method in the post-operative period. Up to 3 1/2 h after start of anaesthesia all patients had a decreased ventilatory response to carbon dioxide. After this period some patients showed a normal respiratory response, while others remained depressed for up to 6 h, the period for which the investigation lasted. Most patients in the depressed group were premedicated with pethidine. We conclude that additional narcotics are contraindicated for a period of 3 1/2 h following the start of neurolept anaesthesia for surgical procedures lasting 1-2 h, while clinical control is still necessary before administration of additional narcotics within 6 h, especially if narcotics have been used as premedication.

Adult↗
PubMed1976

Influence of hypoxia and hyperoxia on subcutaneous adipose tissue blood flow in man.

Subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xe washout method in normal men breathing oxygen at partial pressures from 0.1 to 2 atmospheres. Breathing oxygen at partial pressures of 0.1 and 1 atm. increased and reduced ATBF by 56% and 26%, respectively as compared to air breathing. These effects were highly significant. Breathing of oxygen at 2 atm. partial pressure had no consistent effect on ATBF, although considerable changes--positive or negative--could been seen in some experiments. Oxygen-breathing at 1 atm. partial pressure is associated with a slight hyperventilation and fall in PACO2. This was shown to be without importance for the effect of oxygen on adipose tissue blood flow.

Adipose Tissue↗
PubMed1976

Blood magnesium and the renal magnesium threshold in lichen-fed and fasted reindeer.

In the blood plasma of lichen-fed reindeer the magnesium level was rather low (1.44 +/- 0.17 mg/100 ml) while the levels of calcium, phosphorus and glucose were normal. Fasting for 2--3 days provided no evidence of magnesium deficiency, leading to increments in blood and urinary magnesium. Simultaneous increments in urinary calcium indicated mobilization of bone minerals. The renal magnesium threshold appeared to be at about 1.8 mg of Mg/100 ml of plasma as in other species.

Animals↗
PubMed1975

Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin.

In a pharmacolinetic study on a new semisynthetic penicillin, alpha-sulfobenzylpenicillin, sulbenicillin, serum level, serum half-life, apparent distribution volume, renal clearance, urinary excretion, and metabolism were determined after a 4-gm intravenous dose and compared to that of carbenicillin in 5 patients with normal renal function. In the case of sulbenicillin, the mean serum concentration at 1 hr was 157 plus or minus 25 mug/ml, the mean serum half-life was 70 plus or minus 10 min, the renal clearance was 95 plus or minus 25 ml/min, and the total urinary recovery after 24 hr was about 80% of the dose. The only metabolite detected in the urine was the penicilloic acid derivative, in an amount usually less than 5% of the dose. Serum values, serum half-live, renal clearances, and excretion pattern did not differ significantly from that of carbenicillin. In 8 patients with decreased renal function (creatinine clearance less than 50 ml/min) there was an inverse correlation between creatinine clearance and serum half-life.

Adult↗
PubMed1975

Continuous measurement of arterial PO2, PCO2 and pH during autotransplantation of canine hearts.

Arterial PO2, PCO2 and pH were measured continuously with electrodes placed in a flow cuvette. Comparison between continuous readings and results of single sample analyses showed practically no discrepancy, and the drifts of the electrodes during time of measurements were negligible. During hypothermic perfusion with a Rygg-Kyvsgård bubble oxygenator, autotransplantation of canine hearts was performed. PO2, PCO2 and pH were measured continuously to check the performance of the heart-lung machine, and to evaluate the therapeutic and diagnostic significance of these blood gas values during cardiac surgery. At the start of perfusion, a steep fall in all three parameters was observed. The average fall in PO2 was 313 mmHg; PCO2 fell by 15 mmHg and pH BY 0.15. PCO2 rapidly returned to normal values, while pH and PO2 increased slowly during the perfusion period. PO2 reached its highest value at the lowest temperature and fell during rewarming. PCO was regulated by the carbon dioxide concentration in the heart-lung machine. pH did not return to normal levels within the time of perfusion. In the transistional period from perfusion, PCO2 increased and pH fell. Alterations in the distribution and direction of blood flow and a low systemic blood pressure are possible explanations of the initial fall in PO2 and the post-perfusion changes in PCO2 and pH. The variations in pH and PCO2 at the start of perfusion were caused by an acid priming fluid with low CO2 content. The post-perfusion changes indicated an unstable circulation, but imminent myocardial failure could not alone be diagnosed by continuous measurement.

Animals↗
PubMed1975

Pharmacokinetics of cyclophosphamide in renal failure.

The metabolism of cyclophosphamide was determined in five patients with severe renal insufficiency. After the intravenous injection of 14-C-cyclophosphamide the activities due to unchanged cyclophosphamide and metabolites were determined in samples from urine and serum for 2-3 days. Only 22% of the injected radioactivity could be recovered in the urine during the first 3 days as against the normal of some 65% The rate of biotransformation seemed normal and in agreement with these findings a very long term retention of metabolites could be demonstrated. The clinical implications of these results are discussed.

Aged↗