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Biomedical subjects

E J Sullivan

Publications and source records attributed to E J Sullivan.

At least 37 records · Page 2Linked to original sources
PubMed1993

Histone H1 kinase activity in bovine oocytes following calcium stimulation.

The influence of number of Ca2+ stimulations on the profile of histone H1 kinase activity in bovine oocytes was investigated. A CA2+ stimulation consisted of transferring oocytes directly from culture medium to mannitol containing 100 microM Ca2+ and pulsing oocytes with a 0.2 kVcm-1, 20 microseconds discharge. One, three, or six Ca2+ stimulations were given, each 22 min apart. Oocytes were frozen from 0 to 8 hr after the first stimulation at indicated time points and assayed for histone H1 kinase activity. H1 kinase activity was quantified using a densitometer and expressed as a percent of activity in nonpulsed metaphase II oocytes. Stimulating oocytes in the absence of Ca2+ in the pulsing medium did not inactivate H1 kinase. In the presence of Ca2+, however, H1 kinase was rapidly inactivated after stimulation. A single stimulation decreased H1 kinase activity to 44% +/- 11% of its initial level in 1 hr. However, H1 kinase was dramatically reactivated at 2 hr after the stimulation and reached 122% +/- 22% of the initial activity at 6 hr. With three stimulations, basal H1 kinase activity was 21% +/- 3% and was obtained in 30 min. H1 kinase reactivation started at 4 hr after the first stimulation and level of activity reached 38% +/- 15% at 8 hr. Six stimulations also led to rapid H1 kinase inactivation and to a basal activity of 14% +/- 0.4%. With six stimulations, however, basal H1 kinase activity was maintained over at least 8 hr, and no reactivation occurred during this period. Basal H1 kinase activity obtained after six stimulations was similar to that of fertilized oocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1990

Drug use and disciplinary actions among 300 nurses.

A survey of 300 U.S. nurses recovering from alcohol and other drug dependency was conducted to describe the effect of drug use on job performance and related disciplinary actions. Subjects reported experimentation with or dependence on a variety of drug categories. Many visible effects on job performance were reported but only 23% reported disciplinary action against their nursing licenses. Females and older nurses were more often dependent on alcohol, while younger nurses and males reported narcotic dependency with greater frequency. Narcotic use was significantly related to disciplinary action.

Adult↗
PubMed1987

Nurses' beliefs about the etiology and treatment of alcohol abuse: a national study.

The purpose of this study was to determine registered nurses' beliefs about alcoholism and alcoholics and to compare those beliefs with subjects' biographic and professional variables. A randomly selected national sample of 1026 registered nurses who are members of the American Nurses Association responded to a mailed survey that was designed to determine beliefs about the etiology and preferred treatment of alcohol abusers. Results showed that subjects had more positive beliefs toward alcohol abusers than was found in previous studies. In comparing nurses' beliefs with biographic and professional characteristics, it was found that those who had received their nursing education in hospital diploma programs and those with master's degrees had more positive beliefs about alcoholism than either baccalaureate prepared nurses or nurses with doctoral degrees. Female nurses more often expressed positive beliefs than did male nurses, and nurses working in rural hospitals were more positive than those in urban institutions. Age, length of time in nursing, clinical specialty, type of position, and size and type of institution, were unrelated to beliefs.

Alcoholism↗
PubMed1987

Comparison of chemically dependent and nondependent nurses on familial, personal and professional characteristics.

The characteristics associated with professional impairment due to chemical dependency in nurses are examined. A sample of 139 recovering chemically dependent nurses was compared with a random sample of 384 registered nurses not identified as chemically dependent on familial, personal and professional characteristics. Respondents completed an extensive mailed questionnaire requesting information on demographic variables, family history (past and present), education, employment, medical history, lifestyle characteristics and alcohol- and drug-related behaviors. Significant differences between the two groups were found in gender, familial alcoholism and depression, sexual trauma and functioning, sexual preference, parenthood status, marital history, physical health, depressive illness and alcoholism in spouse. No differences were found in sibling rank, basic nursing education, nursing school class rank, highest educational degree held, academic achievement and length of nursing experience. Recommendations for future study include improved methodology, study of recovery variables and longitudinal follow-up of recovering nurses.

Alcoholism↗
PubMed1985

Assessment center technology. Selecting head nurses.

Assessment center technology is a selection method for supervisory personnel. It uses a candidate's performance in actual work sample exercises. The use of assessment centers in selecting head nurses is explained. Specific results, such as increases in productivity, establishment of standards of practice, and increases in employee satisfaction, are described. Recommendations for assessment center use and suggestions for implementing assessment centers to select nursing managers are presented.

Humans↗