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Biomedical subjects

E J Moynahan

Publications and source records attributed to E J Moynahan.

At least 19 recordsLinked to original sources
PubMed1979

Trace elements in man.

It is likely that most, if not all, of the elements found to be essential in animals will be shown to be so for man, and the clinical picture produced by deficiency of the elements in the human patient will differ little from that seen in the animal, although this has been established for only five elements (I, Fe, Cu, Co and Zn). However, the link between lack of a given element in the soil and a human patient is far less direct and much more complex than that met with in the animal grazing on deficient pastures, except in isolated primitive communitis. Zn is the most protean of the trace elements and has been chosen to illustrate this in human practice. Excesses of essential elements (both trace and major) give rise to toxic effects and the importance of a proper balance especially of the transitional elements in the human diet is discussed with special reference to Cu, Zn and Fe. Certain non-essential trace elements are individual and community hazards: Cd, Pb and Hg are the principal offenders for humans. Mankind is now largely dependent on grassland products, cereals and livestock with increasing dominance of the former in human nutrition. This has reduced the bioavailability of trace elements so that study of trace metals, especially Zn and Cu, in skeletal and dental remains at human burial and occupation sites should prove useful in assessing the consequences of this striking change in dietary habits.

Biological Evolution↗
PubMed1976

Atypical ichthyosiform erythrodernam deafness and keratitis. A report of two cases.

Two patients with ichthyosiform erythroderma of the same unusual but characteristic distribution are described. Both patients were born with perceptive deafness and developed severe vascularizing keratitis in early childhood. There is no family history of the disorder in either case. This syndrome is discussed in relation to previous reports of atypical ichthyosiform erythroderma associated with deafness.

Adult↗
PubMed1976

The tuberous sclerosis syndrome: clinical and EEG studies in 100 children.

The evolution of the early clinical and EEG features in 100 children who developed the tuberous sclerosis syndrome is discussed with particular emphasis on individual variability of epileptic manifestations, skin changes, and mental defect. There were 61 boys and 39 girls. Seizures of various kinds occurred in 98 and in the first 2 years of life infantile spasms were a prominent feature (69) with a partial overlap of other kind of seizures (75). Mental defect (88) and poorly pigmented areas of the skin (77) were already detectable in the first 1 to 2 years of life, while fibroangioma of the face (adenoma sebaceum) (77) and intracranial calcifications (35) became increasingly apparent after the age of 2 to 4 years. The EEG abnormalities tended to be gross in the first 2 years of life, but their subsequent evolution was towards multifocal alterations and some areas of relatively better preserved rhythmic activity. The evolution of the various skin lesions did not run parallel either with that of the clinically detectable seizures or with the appearance of intracranial calcifications.

Adenoma↗
PubMed1975

Familial opsonization defect associated with fatal infantile dermatitis, infections, and histiocytosis.

Members of four generations of a family had a defect of serum opsonization for yeast phagocytosis consistent with dominant inheritance. 2 were healthy, one had chronic osteomyelitis, and the fourth developed a fatal illness in infancy characterized by exfoliative dermatitis, diarrhoea, multiple bacterial infections, and failure to thrive, which resembled the two prevously reported cases with this opsonization defect. At necropsy the infant also had lymphoid depletion, which was possibly secondary, and massive histiocytic infiltration.

Adult↗