Search PubMed⌕ Search

Biomedical subjects

E J Lerner

Publications and source records attributed to E J Lerner.

14 recordsLinked to original sources
PubMed1997

Putting the human body in a computer.

Over the past 20 years, computer simulation has become an invaluable third leg of research in the physical sciences, adding to the traditional tools of theoretical studies and experimental observation. Simulation can give far more accurate pictures than can be provided by theoretical analysis, and show processes that are difficult to observe in detail. Recently, this invaluable tool has been successfully applied to medicine, where the systems tend to be more complex, requiring more computer power. The results are likely to be as far reaching as they have been in physics and chemistry.

Anatomy, Cross-Sectional↗
PubMed1975

Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens (38532).

Diethylstilbestrol, clomiphene, ethamoxytriphetol and triparanol were 0.18, 1.0, 0.02 and 0.01 times as potent in the in vitro inhibition of prostaglandin synthetase, respectively as was indomethacin. In the in vivo carrageenan-induced rat paw edema studies, diethylstilbestrol was more potent as an anti-inflammatory agent than was clomiphene, and ethamoxytriphetol and triparanol were only marginally effective. The most potent of the compounds tested was indomethacin. The results reported demonstrate that the nonsteroidal anti-inflammatory agents and the nonsteroidal estrogens and anti-estrogens share the property of inhibition of prostaglandin synthetase.

Animals↗
PubMedDate not supplied

Bruton-type (congenital X-linked) agammaglobulinemia: MR imaging of unusual intracranial complications.

The authors describe two patients with Bruton-type agammaglobulinemia, their purpose being to indicate the spectrum of findings, clinical and imaging. MR in one patient revealed diffuse leptomeningeal enhancement in the brain and spine; in the second patient, a heterogeneous mass was seen that had broken through the basiocciput and displaced a cerebellar hemisphere. Awareness of the common and unusual CNS manifestations of this disease can impact clinical management.

Adult↗