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Biomedical subjects

E J Field

Publications and source records attributed to E J Field.

At least 91 records · Page 5Linked to original sources
PubMed1973

A common tumour specific antigen. I. Restriction in vivo to malignant neoplastic tissue.

(1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method.(2) Basic protein prepared from human tumour tissue has antigenic properties which differ from basic protein prepared from normal tissues, from hyperplastic tissue and even tumour bearing host tissue.(3) Tumour type antigenic molecules are at least 10(4) times less numerous on normal cells than on tumour cells. If our reasoning is accepted then they are absent from normal cells, and thus restricted in vivo to malignant cells.(4) Hyperplastic tissues (gynaecomastia, etc.) do not contain cancer basic protein.(5) Human chronic lymphatic leukaemic leucocytes possess the same type of cancer antigenic activity as solid tumours. This antigenic activity is not shared by normal lymphocytes.

Animals↗
PubMed1973

Rapid development of a cancer-like antigen in normal tissue in vitro.

Freshly excised human embryonic tissue used as antigen to test lymphocytes from a cancer bearing patient gives a "normal tissue" result of about 10% in the macrophage electrophoresis migration (MEM) test. When, however, it is grown in vitro and then used as an antigenic stimulant to cancer lymphocytes, a "cancerlike" result (about 15%) is produced. These new antigenic determinant(s) akin to those associated with cancer basic protein appear rapidly (within 5.5 hours) in vitro. Cultures of "normal" cells are thus antigenically different from the same cells in context in vivo.

Animals↗
PubMed1973

Lymphocyte sensitization to thymus and lymph node antigen in multiple sclerosis and other neurological diseases.

Circulating lymphocytes from patients with multiple sclerosis are sensitized to saline homogenate of human thymus. They also show a minor degree of sensitization to lymph node extract. The sensitization to thymus is greater in multiple sclerosis than it is in other neurological disease (except dementia paralytica) and this may be related to the degree of parenchymatous destruction which provides the antigen stimulus or to astroglial overgrowth in these diseases. The observations support the view that human brain and thymus may share antigen(s) of the type known as ø-antigen in mice.

Adolescent↗
PubMed1972

Lymphocyte sensitization to carcinoembryonic antigen (Gold) with special reference to multiple sclerosis.

Lymphocytes from patients with multiple sclerosis are sensitized to carcinoembryonic antigen (C.E.A.) in almost the same degree as are those from subjects with cancer. During pregnancy and the early puerperium there is an even higher degree of cellular sensitization to C.E.A. Patients with neurological diseases other than multiple sclerosis also show significant sensitization to C.E.A. though of less degree than do those with multiple sclerosis. Sensitization to C.E.A. is thus not specifically characteristic of cancer. The unexpected sensitization in multiple sclerosis may be associated with the pronounced degree of gliosis found in that condition.

Adolescent↗