Biomedical subjects
Publications and source records attributed to E J Ferris.
A case of type I (type A) aortic dissection proved by postmortem examination could not be fully delineated relative to the type of dissection by dynamic CT as well as three positive contrast aortograms. Small tears in the ascending aorta and their strategic locations can escape even intensive radiologic evaluation. We present a case in which medical therapy was provided and, inappropriately, surgery was not performed.
Loin pain hematuria syndrome occurs primarily in young women and is manifested by recurrent loin pain, hematuria, and abnormal renal vasculature. This syndrome was first described in 1967 by Little in the British literature. Since that time, approximately 60 cases have been reported. In this paper, we describe a case and provide a pertinent review of the literature concerning diagnosis and treatment.
Percutaneous transluminal laser angioplasty is a new method for treating atherosclerotic disease previously not amenable to routine percutaneous transluminal angioplasty techniques. Our results compared favorably with other clinical trials. Patient selection criteria include lesions in the superficial femoral or popliteal system not capable of being treated with routine percutaneous transluminal angioplasty. We think that these lesions include high-grade stenoses or short segmental occlusions. Heavily calcified vessels and long segment occlusions measuring greater than 12 cm in length are probably not amenable to percutaneous transluminal laser angioplasty. The long-term results of this form of therapy for peripheral vascular disease remain unknown.
We have reported a case of a hyperdense parapelvic renal cyst that could not be easily differentiated from a solid tumor by multiple diagnostic studies. However, the typical findings of a hyperdense parapelvic cyst may allow less aggressive surgery.
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Transvenous inferior vena caval filters were placed in 32 patients (21 bird's nest [BN] and 11 Kimray-Greenfield [K-G] filters). Positive contrast cavography was performed before and immediately after filter placement as well as during long-term follow-up studies. In 23 patients, computed tomographic (CT) scanning was also performed; in 10 patients, real-time ultrasound (US) study was used as an adjunct. CT scans of the BN filter showed one case of hemorrhage and one case of air embolism, both of which were not recognized at cavography. CT scanning of the K-G filter demonstrated two cases of deep penetration of the prongs and one large retroperitoneal hematoma. Real-time US scanning played a major role in checking the final position of the filter and in determining its stability during repositioning of the upper prongs of one BN filter. Noninvasive examinations, including CT and US scanning, are valuable adjuncts in immediate and long-term follow-up study of patients with inferior vena caval filters.
Three hundred thirty-seven lower extremities of 256 patients, both symptomatic and asymptomatic, underwent ascending positive contrast venography. Certain anatomic variations were noted to be related to the location and development of deep venous thrombosis (DVT). The thrombus was located entirely in the calf in 44% of asymptomatic limbs and 17% of symptomatic ones (p less than 0.001). There were multiple superficial femoral veins (SFVs) in 31% of the limbs examined, and 40% of those limbs had DVT. This percentage (40%) represented a statistically higher incidence of DVT (p less than 0.001) than those limbs with a single SFV, where the incidence was only 19%. When limbs with multiple SFVs had DVT, only 41% were symptomatic, whereas in those with a single SFV, 72% of the limbs were symptomatic (p less than 0.001). This difference may be the result of internal collaterals due to multiple SFVs. When there were more than five valves in the deep veins between the popliteal fossa and the ischial spine, there was a higher incidence of DVT (35%) as compared to the incidence when there were five or fewer valves (13%) (p less than 0.001).
Making a clinical diagnosis of infection in prosthetic vascular grafts is difficult but when undiagnosed, this condition has a high mortality rate. Using Indium-111-labeled white-blood cells, 30 scans were performed in 21 patients suspected of having a prosthetic graft infection. The diagnosis of infected graft was confirmed by surgery in all cases, and lack of infection was established by resolution of symptoms with conservative therapy. Twenty-four hour scans of autologous Indium-111 leukocytes were obtained, and correlative CT studies were done in 11 cases. There were 13 infected grafts at surgery (purulent material present), and scans were positive in all (100% sensitivity); of 17 scans, there were 15 true negatives and two false positives (88% specificity). Using the criteria of gas or fluid around the graft, the sensitivity of CT was only 37% in a small subset of these patients. One-half of the cases in which infection was suspected clinically had no infection and had negative scans. Various types of grafts and graft materials were used, and there was no correlation with presence or absence of infection on the basis of the type of graft. Extragraft infection sites were found in five patients. In conclusion, use of Indium-111 leukocytes has been found to be an accurate and valuable diagnostic method for evaluation of suspected prosthetic vascular graft infection, and to have higher diagnostic accuracy than CT.
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Angioscopy was used during in situ saphenous vein bypass grafting in seven patients. We were able to visualize valve incision, immediately identify and correct incomplete valvulotomy, identify side branches as potential arteriovenous fistulas, and assess distal anastomotic integrity. We encountered no retained valve cusps after angioscopy, as verified by Doppler ultrasound and completion angiography. Angioscopy verified distal anastomotic integrity in all patients with distal vein grafts large enough to accept the angioscope. Angioscopy requires minimal time, is relatively easy to use, serves as an adjunct to Doppler ultrasound and completion angiography, and has future potential as a therapeutic tool.
The cardiovascular applications of flexible fiber-optic technology are imminent because of recent advances in miniaturization. In the work described here, angioscopy, or vascular endoscopy, was performed in the cadaveric aorta and in the systemic and pulmonary circulations of the canine model and selected human patients. Subsequent to our development of percutaneous techniques, clinical trials have ranged from lower-extremity venoscopy to aortic-root arterioscopy. Angioscopy could be clinically useful because of relative or absolute contraindications to iodinated contrast material. The ability to see in color and three dimensions may afford some other advantages to angioscopy over conventional angiography.
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Fifty-eight patients, 38 of whom had pulmonary emboli, were evaluated for pulmonary occlusive disease with flow-directed balloon occlusion pulmonary cineangiography. Areas studied were selected by radionuclide perfusion lung scans and indeterminant areas of pulmonary occlusion were imaged on standard catheter pulmonary magnification cut films. In 4 of 38 patients, the balloon occlusion technique demonstrated peripheral pulmonary emboli not seen on standard pulmonary arteriography. Selective flow-directed balloon occlusion pulmonary cineangiography is an effective adjunct for evaluating some patients with pulmonary emboli.
The value of digital pulmonary arteriography and balloon-occlusion cineangiography was investigated in 118 selected patients. In one series of 40 patients, digital pulmonary arteriography correctly identified pulmonary emboli in 20 (75%) of 26 positive examinations when interpretation was confined to the first three divisions of the pulmonary artery. In a second series of 78 patients with peripheral radionuclide perfusion scan defects, 40 of whom had pulmonary emboli, adjunctive balloon-occlusion cineangiography demonstrated emboli in four patients not seen on standard selective catheter pulmonary magnification studies with cut films. These two procedures (i.e., digital pulmonary arteriography and balloon-occlusion cineangiography) are important adjuncts to radionuclide perfusion scans and selective catheter pulmonary arteriography in the evaluation of patients with pulmonary emboli.
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