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Biomedical subjects

E J Conway

Publications and source records attributed to E J Conway.

At least 19 recordsLinked to original sources
PubMed1999

Sympathetic storms in a child with a midbrain glioma: a variant of diencephalic seizures.

The authors report the unusual case of a 7-year-old child, one of the youngest reported to date, who developed repeated episodes of sympathetic hyperactivity after surgical resection of a midbrain glioma. These paroxysmal events were similar to previously described diencephalic seizures. However, there was no evidence of epileptogenic activity on electroencephalography, and radiologic imaging did not reveal hydrocephalus or intraparenchymal hemorrhage. In this report, clinical features are described of this patient, along with the novel use of clonidine--a sympathetic blocking agent--in his treatment, published reports are reviewed on diencephalic seizures, and steps are recommended in the treatment of a patient who presents in this manner. The authors believe that diencephalic seizures can present with a spectrum of autonomic features, and treatment should be tailored with the appropriate pharmacologic blockade.

Anticonvulsants↗
PubMed1996

Absence of evidence for an etiologic role for Epstein-Barr virus in neoplasms of the lung and pleura.

Although most lung carcinomas and mesotheliomas are associated with well-known risk factors, these cancers develop in only a minority of persons exposed to known risk factors. On the other hand, these cancers develop in some patients without exposure to known risk factors. This indicates that other environmental factors play a role in the carcinogenesis of these tumors. Oncogenic viruses such as Epstein-Barr virus (EBC) are well-established agents in the development of certain cancers. EBV genomes have been detected by in situ hybridization in gastric adenocarcinomas and in nasopharyngeal carcinomas. To determine whether EBV infection is associated with pulmonary adenocarcinoma or mesothelioma, we performed EBV-encoded RNA-1 in situ hybridization on 80 pulmonary adenocarcinoma and 50 mesothelioma resection specimens. Sections were cut from paraffin-embedded tissue and EBV-encoded RNA-1 in situ hybridization was performed using an antisense oligoprobe. Sections were reviewed for the presence of EBV-encoded RNA-1 in tumor cells. All 80 adenocarcinomas and 50 mesotheliomas were negative for EBV-encoded RNA-1 by in situ hybridization. In conclusion, no evidence for an etiologic role for EBV in the development of pulmonary adenocarcinoma or pleural mesothelioma was found in this study.

Adenocarcinoma↗
PubMed1968

The relation between sodium ion content and efflux of labelled sodium ions from yeast.

1. The activity of the Na(+) pump in an Na(+)-rich yeast was compared with that in an Na(+)-rich frog sartorius muscle, and found to be very similar to it over the first hour if both were immersed in fluid containing 104mm-Na(+) plus 10mm-K(+). 2. The efflux of labelled Na(+) from an Na(+)-rich yeast into an Na(+)-free medium was investigated. In this Na(+)-free medium, Li(+) or choline replaced the Na(+), and the efflux-content curves obtained with either of these ions were very similar. The curves were sigmoid, reaching or approaching a saturation at the higher internal Na(+) concentrations. 3. The curves obtained with yeast resembled those similarly obtained with frog sartorius muscle by Keynes & Swan (1959), Mullins & Frumento (1963), Harris (1965) and Keynes (1965). The slope of the plot of the logarithm of the Na(+) efflux against the logarithm of the Na(+) concentration in the cells reached its highest value at an internal Na(+) concentration of 15m-equiv./kg. (27m-equiv./l. of cell water). 4. The effect of external K(+) concentration on the efflux-content relationship was examined. An increased K(+) concentration was found to increase the Na(+) efflux by raising the saturation value, which is similar to observations made by Harris (1965) with frog muscle. 5. The effect of increasing the external carbon dioxide concentration was investigated. No effect on the slope of the plot of the logarithm of the Na(+) efflux against the logarithm of the Na(+) content was noticed even when the yeast suspension was equilibrated with 100% carbon dioxide. There was, however, a decrease in the amount of Na(+) efflux on equilibrating the solution with carbon dioxide.

Animals↗
PubMed1966

The further preparation of inorganic cationic yeasts and some of their chief properties.

1. A method is described for replacing the intracellular K(+) of the yeast cell by Rb(+), Cs(+), Li(+) or Ca(2+) ions. In the formation of a calcium yeast it is necessary to proceed first through a sodium yeast (Conway & Moore, 1954) as in the formation of a magnesium yeast (Conway & Beary, 1962). This concludes the series of such yeasts in which almost all the usual K(+) is replaced by another cation, and for which the effect on the properties of fermentation, oxygen uptake and of growth are described. 2. Previous work has shown that all these inorganic cations that can be accumulated in quantity at pH7.0 are taken up by the same carrier, that the uptake of Mg(2+) is almost completely inhibited by anoxia and cyanide (0.2mm) and that in the uptake of Mg(2+) ions a practically equivalent amount of H(+) ions is excreted. It is suggested that these facts amount to a definitive demonstration that the carrier is a cytochrome.

Calcium↗
PubMed1939

Blood ammonia.

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Journal Article↗