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Biomedical subjects

E Ippolito

Publications and source records attributed to E Ippolito.

At least 73 records · Page 4Linked to original sources

Subungual exostosis. Histological and clinical considerations on 30 cases.

The authors review 30 cases of subungual exostosis, 27 in the foot and 3 in the hand. In approximately 80% of the cases, errors in initial diagnosis had been made, and the affection had been confused with ordinary verrucae, mycoses or pyogenic disease. Histological examination showed that in some cases the neoformation ossified by an enchondral mechanism similar to that of osteocartilaginous exostosis, while more often the mechanism was of the intramembranous or mixed type. The treatment consisted of resection of the exostosis at its base after removing the nail. Complete healing occurred in all cases.

Adolescent↗

Subperiosteal osteoid osteoma: a case report.

A 32-year-old woman with persistent knee pain, similar to that caused by a meniscus tear, was found to have a subperiosteal osteoid osteoma of the medial condyle of the knee. Osteoid osteoma with this presentation and location does not seem to have been reported previously.

Adult↗

Idiopathic muscular torticollis in adults. Results of open sternocleidomastoid tenotomy.

Eight adult patients who underwent open tenotomy for idiopathic muscular torticollis were evaluated with an average follow-up of 14 years. The age of the patients at operation ranged from 20 to 37 years, with an average of 26 years. The sternal head of the sternocleidomastoid muscle was divided in two patients, both the sternal and the clavicular heads were divided in five patients, and in one patient all three heads were divided. After the operation a Minerva plaster cast was applied with the head hyperextended, bent away from the deformity, and rotated towards the deformity. Neurovascular complications were not observed. Facial asymmetry did not improve after surgery, but at follow-up all the patients had a satisfactory range of motion of the neck, although the radiographic alterations of the cervical spine present before the operation had not improved.

Adult↗

Idiopathic chondrolysis of the hip: an ultrastructural study of the articular cartilage of the femoral head.

Core biopsies obtained from the articular cartilage of the femoral head of a 16-year-old girl with idiopathic chondrolysis of the hip were subjected to an ultrastructural study. Zone I was missing and zone II was the most superficial layer present in the articular cartilage of our patient. Collagen fibrils were thinner than normal and more uniform in diameter, and proteoglycans were normally distributed among them. Degenerating chondrocytes were found, as well as debris of dead cells, but many chondrocytes were still vital and engaged in active synthesis. Most of the chronic degenerative changes observed in ultrastructural studies on osteoarthritis were not observed in this case of idiopathic chondrolysis which seems to be, on the basis of our findings, a pathological process which develops and runs its course very quickly.

Adolescent↗

Rare forms of chondroblastoma. Cystic and diaphyseal types.

The authors describe 4 cases of cystic chondroblastoma, three located in the epiphysis and one in the diaphysis. In 2 cases, the tumour macroscopically resembled a simple bone cyst and the tumour tissue consisted of small collections of cells lining the cystic cavity, which was devoid of fluid contents. In the other 2 cases, the tumour macroscopically resembled an aneurysmal bone cyst, but the thin septi that separated the blood-filled lacunae consisted of chondroblastomatous tissue. In this variety of chondroblastoma, curettage of the cystic cavity must be particulary meticulous so as to avoid local recurrence should small islands of neoplastic tissue inadvertently be left behind.

Adolescent↗

Transient osteoporosis of the hip.

The authors report 6 cases of transient osteoporosis of the hip. This is a rare disease but it should nevertheless be taken into account in the differential diagnosis with other inflammatory or neoplastic diseases of the hip. Even without treatment, it tends to regress spontaneously, but the pain can sometimes last for several months. Calcitonin is a reliable therapeutic agent and considerably shortens the natural course of the disease.

Adult↗

Supracondylar fractures of the humerus in children. Analysis at maturity of fifty-three patients treated conservatively.

From a pool of 131 supracondylar fractures of the humerus in 131 patients who were treated conservatively, all of which healed in an average time of 4.5 weeks without complications related to the treatment itself, the cases of fifty-three patients were reviewed at maturity. The average age at follow-up was twenty-six years. Nine patients had unimportant limitation of elbow motion, and slight atrophy of the musculature of the arm or forearm, or of both, was present in six patients. Arm-length discrepancy was never observed. The carrying angle remained at about the same value that had been present at the time of fracture-healing in eighteen patients, decreased in twenty-two patients, and increased in thirteen. Malrotation of the distal fragment of the fracture only rarely caused medial tilting of the fragment with consequent cubitus varus. Varus deformity was present in four patients and valgus deformity, in three. None of the patients with valgus deformity had ulnar-nerve palsy. According to our results, varus and valgus deformities of the elbow after supracondylar fractures of the humerus seem to be caused either by growth imbalance of the growth plate of the distal end of the humerus (four patients) or by malreduction of the fracture (three patients). Twelve patients in the entire pool had neurological complications at the time of the fracture. Ten of those patients fully recovered from the deficit, whereas two--one with a radial-nerve deficit and the other with ulnar-nerve involvement--still had neurological impairment at follow-up.

Adolescent↗

[Phytopack Ispex in the treatment of degenerative arthropathies and insertion tendinopathies. Telethermographic study].

The authors have studied the antiflogistic properties of a fitotherapic agent used in course of rheumatic and degenerative joint and tendon disease. The control of the therapeutic activity of the agent has been checked out by mean of telethermography. The best results were mainly obtained in cases of osteoarthritis and tendonitis, in which a real reduction of the stermic value showed a parallel decrease of the flogistic process involving joints and tendons.

Adult↗

De Quervain's disease. An ultrastructural study.

The tendon sheaths of extensor pollicis brevis (EPB) and abductor pollicis longus (APL), obtained from four patients with de Quervain's disease were studied by light and electron microscopy. Three different layers were identified in the sheath which was much thicker than normal. Both the outer and the middle layers had thick bundles of collagen fibres with scattered fibroblasts. The inner layer was mainly formed by chondroid and myxomatous tissue. Collagen fibrils were thicker than normal, reaching 2100 nm in diameter. Numerous cells which resembled "myofibroblasts" were scattered throughout the whole thickness of the sheath. The results seem to indicate that thickening and hardening of the EPB and APL tendon sheaths in de Quervain's disease is caused by increased synthesis of the extracellular matrix, increased thickness of the collagen fibrils and areas of myxomatous and chondroid metaplasia.

Adult↗

Long-term results of open sternocleidomastoid tenotomy for idiopathic muscular torticollis.

At the end of their skeletal growth, we evaluated the cases of sixty-seven patients who had had an open tenotomy of the sternal and clavicular origins of the sternocleidomastoid muscle for idiopathic muscular torticollis. The average length of follow-up was 15.4 years, and the average age at the last follow-up was 23.9 years. The patients were divided into three groups according to their age at the time of operation. Group I consisted of patients who were operated on between the ages of five months and six years; Group II, of patients who were operated on between the ages of seven and eleven years; and Group III, of patients who were operated on when they were twelve years old or older. According to our method of evaluation, 37 per cent of the patients had a good, 45 per cent had a fair, and 18 per cent had a poor result. The patients in Group I had the best results and those in Group III, the worst. In general, the patient's age at operation, the duration of the disease, and the severity of the deformity before the operation had the major effects on both cosmetic and functional results.

Adolescent↗

The treatment of relapsing clubfoot by tibialis anterior transfer underneath the extensor retinaculum.

Nineteen patients with 22 relapsing clubfeet were treated by tibialis anterior transfer underneath the extensor retinaculum. This operation is indicated in cases of relapse in which the clubfoot is still supple. It is not indicated in cases with subtalar rigidity. The results were excellent in 19 cases, fair in 2 and poor in one. The fair and poor results were attributable to faulty technique or errors of indication.

Child↗

Köhler's disease of the tarsal navicular: long-term follow-up of 12 cases.

Twelve patients with Köhler's disease of the tarsal navicular were reviewed at follow-up averaging 33 years after diagnosis. All patients were asymptomatic. Neither alteration of the navicular shape nor osteoarthritis was observed radiographically. The type of treatment did not affect the time required for bone restoration, which took an average of 8 months. Weightbearing plaster casts for 3 months rendered the patients pain-free, whereas arch supports only decreased local pain, which lasted for an average of 7 months.

Casts, Surgical↗

Vertebra plana. Long-term follow-up in five patients.

Five patients with vertebra plana were followed for twelve to thirty years after the diagnosis had been made. Histiocytosis X had been the presumptive diagnosis in all five patients. Their ages at diagnosis ranged from four to twelve years and at follow-up, from nineteen to forty years. When they were last seen, none of the patients complained of symptoms related to the original disease, and the radiographs showed reconstitution of the vertebral height equivalent to 48 to 95 per cent of normal, with no sign of osteoarthritis. The best radiographic results occurred in the two youngest patients, who had involvement of the first lumbar vertebra, whereas the patient who was oldest at follow-up, with vertebra plana in the ninth thoracic vertebra, had the worst result. The four patients with just vertebra plana were treated with a plaster jacket and a brace, whereas the one with multicentric skeletal involvement had chemotherapy as well as orthopaedic treatment.

Adult↗

The osteochondroses. A new pathological concept.

In all histopathological studies of the osteochondroses, the one constant finding is a dysplastic change in the cartilaginous epiphysis and apophysis. This gives rise to disturbances of enchondral ossification, diminished mechanical resistance of the abnormal cartilage, and to ischaemic changes in the ossific nucleus. This has been demonstrated histologically only in Perthes disease and Köhler's disease and probably reflects vascular damage provoked by abnormal cartilaginous growth. Cartilage dysplasia could constitute the fundamental pathogenetic background common to all the osteochondroses.

Cartilage, Articular↗

Mechanisms of acetabular growth in the foetus in relation to the pathogenesis and treatment of congenital dislocation of the hip.

The development of the acetabulum has been studied histologically and histochemistry from the beginning of the foetal period to birth. The acetabular roof develops by interstitial growth of the acetabular cartilage and the limbus, enchodral ossification of the growth cartilage of the acetabulum and periosteal ossification of the iliac ala. In congenital dislocation of the hip (C.D.H.) this mechanism is altered but can be restored to normal by stable reduction during the first 4-5 years of life. Plastic operations to create a new roof ("shelf operations") are often destined to failure because they can not only damage the delicate histological structures concerned in the growth of the acetabulum, but the bone grafts used do not grow like the neighbouring osteocartilaginous structures.

Acetabulum↗

Post-traumatic valgus deformity of the knee in proximal tibial metaphyseal fractures in children.

Fractures of the proximal metaphysis of the tibia in children, not involving the growth cartilage and even if there is no significant displacement between the fragments, may give rise to post-traumatic valgus deformity of the knee. This deformity generally tends to be self-correcting if less than 15 degrees but if it is beyond this it does not have the same tendency to spontaneous correction. In such circumstances the normal alignment should be re-established by osteotomy and epiphysiodesis.

Child↗