Biomedical subjects
Publications and source records attributed to E Inoue.
Two patients with primary pneumatosis cystoides intestinalis are presented. In both cases, the sigmoid colon was involved and there were no major complications. On computed tomography (CT), at lung window settings, the gas cysts in the colonic wall were clearly delineated. CT was useful in confirming the intramural gas cysts in patients with primary pneumatosis cystoides intestinalis.
PURPOSE: To evaluate the usefulness of a dye-injection method in the placement of an infusion catheter and port via proximal branches of the axillary artery for hepatic infusion chemotherapy. MATERIALS AND METHODS: Sixteen patients with surgically unresectable hepatic cancer underwent transfemoral hepatic arteriography. Then a 3-F coaxial catheter was inserted into a proximal branch of the left axillary artery. Dye injected through the coaxial catheter during the surgical procedure improved the visualization of the target branch. The coaxial catheter was also used as a guide for retrograde insertion through the target branch of an infusion catheter into the descending aorta. RESULTS: In 13 of 16 patients (81%), catheterization was successful without exposure of the axillary artery. In these patients, the acromial-deltoid branch of the thoracoacromial artery was chosen as the target. CONCLUSION: Injection of dye simplifies the surgical procedure for placement of a hepatic infusion catheter via proximal branches of the axillary artery. The depth and extent of incisions, as well as the risk of nerve injury, are reduced.
Twenty small hepatocellular carcinomas (HCCs) < 20 mm in diameter in 18 patients, detected by MRI, were surgically resected and histologically confirmed. Quantitative analysis of signal intensity on MR images was performed with 14 homogeneous lesions. In the five grade I HCCs, T1-weighted SE sequences provided significantly higher mean tumor-liver contrast and contrast-to-noise ratio (C/N) than T2-weighted SE sequences (p < 0.01). However, in the other nine HCCs (grade I + II or greater), T2-weighted SE sequences had significantly higher mean tumor-liver contrast and C/N values than T1-weighted SE sequences (p < 0.001). The T2-weighted SE sequences appear superior to T1-weighted SE sequences for grade I + II or greater HCC detection, whereas T1-weighted SE sequences are valuable in the detection of grade I HCCs.
PURPOSE: Our goal was to evaluate the contribution of double phase CT arteriography (CTA) of the whole liver to differentiate hepatic tumors from false-positive areas on CT during arterial portography (CTAP). METHODS: In 38 candidates for surgical resection of hepatic tumors, both CTAP and double phase CTA were performed. A total of 68 perfusion defects were identified at CTAP. Of 68 perfusion defects, 47 were found to represent hepatic tumors [hepatocellular carcinoma (HCC), n = 31; hepatic metastasis, n = 13; cholangiocarcinoma n = 2; focal nodular hyperplasia, n = 1]. The other 21 perfusion defects were defined as perfusion abnormalities in which focal hepatic masses had not been identified at surgery or pathologic analysis. The phase one CTA scanning started 12 s after the beginning of the injection of contrast material, and the phase two CTA scanning started 20 s after the end of the phase one CTA, with 60 ml of contrast agent (150 mg I/ml) injected at a rate of 2 ml/s. RESULTS: On phase one CTA, only 1 lesion in 31 HCCs showed rim enhancement and 26 HCCs (84%) had rim enhancement on phase two CTA. Twelve lesions (80%) of the hepatic metastases and cholangiocarcinomas had rim enhancement on phase one CTA and 11 lesions (73%) showed rim enhancement on phase two CTA. Twenty-one perfusion abnormalities on CTAP did not show rim enhancement on either phase one or phase two CTA. CONCLUSION: Double phase CT arteriography of the whole liver was useful to differentiate hepatic tumors from perfusion abnormalities on CTAP.
The antibacterial and bactericidal activities and the stability of FK037 to beta-lactamases were investigated and compared with those of cefpirome, flomoxef, ceftazidime, ceftizoxime, and vancomycin. Against clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus, FK037 was less active than vancomycin but more potent than the other drugs tested. Among highly methicillin-resistant staphylococci (MIC for methicillin: 200 mg/l or higher), none of the strains were highly resistant to FK037 (MIC > or = 100 mg/l) unlike the other cephalosporins. With the exception of Enterococcus faecalis, FK037 had an activity equipotent to that of cefpirome and far superior to those of flomoxef, ceftazidime and ceftizoxime against other gram-positive clinical isolates. The activity of FK037 against Pseudomonas aeruginosa and Pseudomonas cepacia was equipotent to that of cefpirome but 2- to 4-fold less active than that of ceftazidime. FK037 inhibited 90% of Enterobacter cloacae and Citrobacter freundii growth at a concentration of 6.25 mg/l; it was as active as cefpirome and much more active than ceftazidime. Against the other gram-negative bacteria tested, FK037 was equipotent to cefpirome and ceftazidime and was more effective than flomoxef. FK037, like cefpirome, portrayed a high stability to various beta-lactamases except type II penicillinase and oxyimino-cephalosporinase (CXase). FK037 scored an MIC range of 0.013-6.25 mg/l against numerous beta-lactamase-producing bacterial strains with the exception of some CXase-producing strains and a cephalosporinase-producing C. freundii; and against strains other than P. aeruginosa FK037 was as active as cefpirome and 2- to 32-fold more active than ceftazidime. FK037 displayed highly potent activities against cephalosporinase-producing E. cloacae, C. freundii and Serratia marcescens which were resistant to flomoxef and ceftizoxime. FK037 was highly bactericidal against S. aureus and Escherichia coli at its MIC or higher.
PURPOSE: To analyze the relationship between the experience of side effect and the compliance with oral steroids drug treatment of the patients in Collagen Disease Clinic. METHODS: A questionnaire survey through interview was conducted on 165 outpatients with various collagen disease at Saga Medical School Hospital. RESULTS: 94 patients (57%) had a history of noncompliance to the steroids drug. 49 patients (52.1%) adventitiously had forgotten to take the steroids as ordered and 45 patients (47.9%) intentionally had regulated their steroids dose or had discontinued the steroids drug treatment. Over 80% of the patients had experienced side effects of the steroids. The patients who experienced one or more of the following side effects, osteoporosis, bone fractures, menstrual disorders, moon face, central obesity, alopecia, acnelike eruption, manic-depressive state, and insomnia, intentionally regulated, or discontinued the steroids therapy. In addition, the patients who were not made cognizance about side effects of the steroids by their physicians and nurse tended to noncompliance group. CONCLUSION: To increase the compliance rate with oral steroids drug treatment, we must make conscious efforts to inform the patients on the condition of their medical states, the efficacy of the prescribed drugs, and the side effects and risk concerning discontinuation of the steroids. It is Also necessary to establish "Drug information and counseling day" in outpatient Department.
The research presented in this article examined the role of oxygen in preventing diaphragmatic motion artifacts in delayed-phase hepatic digital subtraction angiography (DSA). The results demonstrate that administering oxygen to patients before the examination substantially reduces artifacts due to motion.