[Study of the regulation of streptomycin biosynthesis using a blocked mutant of Act. streptomycini].
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Carbon Radioisotopes↗
Biomedical subjects
E Ia Kornitskaia
Publications and source records attributed to E Ia Kornitskaia.
[Characteristics of the interaction of the A-factor with mutant 1439 of Act. streptomycini in the biosynthesis of streptomycin].
Some peculiar properties of A-factor using by mutant 1439 of Act. streptomycini were studied. It was found that A-factor was most intensively used for biosynthesis of streptomycin when it was added during inoculation. When A-factor was added to a I- or 2-day culture it was required in 10 times higher amounts and its high non-specific adsorption by the mycelium was observed. Interaction of A-factor with the mycelium providing restoration of the biosynthetic process was very rapid on a short-term contat of the I-day culture with A-factor. Transformations occurring under the effect of A-factor and leading to formation of streptomycin took place mainly inside the cells. Changes in the life cycle induced by A-factor developed under different conditions as compared to those promoting streptomycin biosynthesis.
Bacteriological Techniques↗
[Role of the A-factor in the biosynthesis of streptomycin].
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Genetics, Microbial↗
[The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini].
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Chromatography, Gel↗
[Arginine as a source of amidine groups in the biosynthesis of streptomycin].
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Arginine↗
[A-factor formation by different actinomycetes].
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Actinomycetales↗