Search PubMed⌕ Search

Biomedical subjects

E Ia Drukin

Publications and source records attributed to E Ia Drukin.

At least 19 recordsLinked to original sources
PubMed1999

[The use of Neupogen in prevention of purulent septic complications after radical surgery for esophageal cancer].

To prevent purulent complications, a granulocyte-colony stimulating factor--filgrastim-neupogen (200 or 480 mg) was injected during radical surgery and for the following 6 weeks in 26 patients with esophageal tumors and gastric cancer disseminated to the esophagus. A significant rise in leukocyte levels which potentiated antibacterial therapy was recorded in all patients. Purulent septic complication was registered in one case.

Adult↗
PubMed1989

[The role of conservative resection in surgical treatment of patients with lung cancer].

The immediate and end results of 56 limited segmental resections of the lung (palliative--12 and radical--44) for cancer were studied. Postoperative mortality was 6.8% and five-year survival--50.0%. It is suggested that surgery for peripheral cancer without regional metastasis should be recommended for tumors under 2 cm in diameter in poor-risk patients. The procedure should be preferred for treatment of adenocarcinoma.

Aged↗
PubMed1989

[Evaluation of diagnosis and treatment of various clinico-anatomical forms of lung cancer].

Among 3898 cases of primary lung cancer registered in Leningrad within 1985-1986, central cancer clearly predominated (61.9%). Central/peripheral cancer ratio was 1.6:1. The most common procedure used for treatment of central lung cancer was pneumonectomy (74.6% of cases) and lobectomy--for peripheral cancer management (85.7%). Significant differences in approach to diagnosis and surgical treatment of these pathologies were established. It seems unfeasible to increase resectability of central lung carcinoma by extending surgery. Such tumors should be diagnosed at the stage of segment involvement. However, prophylactic photo-roentgenography does not assure early detection of central lung cancer. Organization of lung cancer detection in Leningrad needs to be improved.

Aged↗
PubMed1989

[Diagnosis of central cancer of the lungs].

Data on 396 patients with central cancer of the lung admitted to the thoracal department of the Petrov Research Institute of Oncology and the City Oncological Dispensary in 1985-1986 are presented. In 94 of them (23.7%) the disease was diagnosed by prophylactic roentgenofluorography, in 302 (76.3%)--in consultation with a doctor. Operability of the patients of the first group was somewhat higher than in those of the second group. During the two years under analysis the roentgenofluorography detected central cancer of the lung in 266 patients (11%). Radical operations were performed in 48 patients (18%), while in patients consulted by doctors after the appearance of clinical symptoms of the disease, resectability made up 13.3%. Main efforts should be directed to the active detection of central cancer of the lung in patients who addressed the polyclinic for lung symptoms.

Adult↗
PubMed1987

[Factors determining the status of the surgical care of lung cancer patients in a large industrial center].

The report deals with the dynamics of resectability in 30,456 patients with lung cancer registered in Leningrad in 1968-1985 versus such important characteristics of morbidity as yearly increase in tumor incidence and increasing age of patients. It also discusses possible total levels of operability and resectability as well as those in different age groups versus sex, diagnostic, functional and biological characteristics and patients' refusal to be operated. Standards of surgical treatment for lung cancer in certain localities should be evaluated versus expected level of resectability, and age and sex.

Adult↗
PubMed1985

[Histological structure and tumor size as prognostic factors in the surgical treatment of patients with peripheral lung cancer].

An analysis of long-term (5 years) results of treatment of 444 patients with peripheral lung cancer has shown that in adenocarcinoma the tumor size is of no significance for prognosis of the disease while in squamous cell carcinoma of more than 5 cm diameter the prognosis is significantly worse (almost 2 times). Since the squamous cell carcinoma is known to be the less biologically active form of lung carcinomas the authors consider that the main task is the organization of measures for early detection of this kind of tumors less than 5 cm in diameter.

Adenocarcinoma↗
PubMed1984

[Growth rate as one of the characteristics of peripheral lung cancer].

A correlation between the rate of growth of peripheral cancer of the lung and patient's age was established by a study involving 262 cases. The duration of tumor presence in the body appeared to be a factor influencing the process of tumor dissemination to regional lymph nodes. An analysis of the long-term results of surgical treatment of 127 patients yielded a significant correlation between the time of doubling of tumor size and survival within the first two years after operation. At later stages, survival rates tended to rise in patients with slowly-growing tumors, with the exception of those with the tumor doubling time under 20 days and a bad prognosis.

Adenocarcinoma↗
PubMed1983

[Lung cancer in patients over 70].

The validity of the surgical treatment has been established by the investigation of immediate and late results of the treatment of 118 patients with lung cancer aged from 70 to 84. The postoperative lethality was 17,8%, the 5-year survival being 25,8% of the patients discharged from the hospital. No biologically specific features of lung carcinoma in patients older than 70 were found which could promise longer life of such patients without surgery.

Age Factors↗
PubMed1981

[Surgical treatment of lung cancer in patients with concurrent cardiovascular system diseases].

The data are reported on 1000 patients operated upon for lung cancer, in 290 of them concomitant cardiovascular lesions have been revealed. The postoperative mortality was found to be higher in patients with postinfarction cardiosclerosis, hypertension of stage II--III at the age under 59, while in chronic coronary insufficiency, arrhythmia and impaired conductivity the mortality rate was not increased. In patients over 60 the postoperative mortality was higher than in young patients, however, a concomitant cardiovascular pathology rendered no appreciable effect. A 5-year survival in concomitant cardiovascular pathology was 25% versus 33.3% in control patients, that is attributed by the authors to a large number of "compromise" saving operations in patients with concomitant cardiovascular lesions.

Adult↗
PubMed1981

[Life expectancy of lung cancer patients registered at the Leningrad City Oncological Dispensary in 1968].

Out of 1,240 lung cancer patients, a five-year survival was registered in 5.2% of cases (0.5% of unoperated patients, 34.3% of radically-operated among those who underwent surgery and 39.5% of patients discharged from hospital after operation). No relationship between the sex and age unoperated patients and prognosis was established. Among those radically-operated, 34.8% of young all 28% of aged patients survived for five years. Resectability should be considered the only reliable criterion of evaluation of diagnosis and treatment of lung cancer.

Adult↗
PubMed1980

[Extensive and combined operations of lung cancer].

Two hundred and eighteen patients were operated upon with the postoperative mortality in 15.2%. Among those who died at the hospital the operation was not radical enough in 34.9%. Distinguishing between extensive and combined operations seems to be warranted due to different postoperative mortality and, mainly, due to better late results following the combined operations. A 3-year survival for the whole group-16%, a 5-year survival - 10.3%. In patients with metastases a 3-year survival - 6.3%, a 5-year survival - 6.25%, without metastases a 3-year survival - 24.5%, a 5-year survival - 15.4%. Extensive and combined operations are warranted irrespective of the histological tumor structure in cases without any metastases in lymph nodes, but only in squamous cell cancer with lymph node metastases. Taking account of an unfavourable prognosis these operations should be referred to as conventionally radical.

Female↗
PubMed1978

[Combination of primary lung cancer with extrapulmonary carcinomas].

An analysis is given of 50 observations of lung cancer associated with cancer of other organs. Lung cancer was preceded by cancer of another organ in 33 patients (66%), cancer of another organ developed after lung cancer had been cured--in 6 (12%), and synchronous involvement was noted in II (22%). An average interval between radical surgery for lung cancer and subsequent tumor growth in another organ was 6.2 years. Among patients with synchronous carcinomas the association with laryngeal cancer (4) and cancer of the stomach (4) was most frequently noted. The principles of treatment in patients with synchronous carcinomas are described.

Adult↗