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Biomedical subjects

E I Sidorenko

Publications and source records attributed to E I Sidorenko.

At least 19 recordsLinked to original sources
PubMed2005

Are screening and surveillance for Barrett's oesophagus really worthwhile?

Oesophageal adenocarcinoma has a low incidence and still remains an uncommon cancer; however, it has been on the rise over the past 20 years. Barrett's oesophagus, a complication of gastro-oesophageal reflux disease, is the only known precursor of this adenocarcinoma. It can often be asymptomatic and probably goes undiagnosed in the majority of the population. There are no direct data supporting the practice of screening for Barrett's oesophagus and oesophageal adenocarcinoma among the general population or even in patients with chronic reflux symptoms. However, many argue that the detection of neoplasms at a curable state in a high risk population can perhaps justify screening endoscopy. No prospective, controlled trials have been conducted to support the effectiveness of surveillance, but some indirect evidence does exist. The cost effectiveness of surveillance programmes needs to be further assessed in prospective studies. Ultimately, the use of better tools to diagnose Barrett's oesophagus and dysplasia and the identification of high risk groups for progression to oesophageal adenocarcinoma could potentially make screening and surveillance a cost effective practice.

Adenocarcinoma↗
PubMed2002

[Multiple sclerosis with early onset: pathogenesis, clinical characteristics, possibilities in the treatment of its pathogenesis].

Early onset multiple sclerosis (MS) has some peculiarities in the disease course. 56 patients with definite MS with the onset at the age under 15 years were included in this clinical, immunogenetical and neurophisiological study. The analyses of the relations between different clinical characteristics of MS in children has shown, that patients with onset under 10 years, had rare relapses, but more progressive development of disability in contrast to the patients with MS onset at the age of 11-15 years. Duration of the first remission was associated with the time to sustained disability in children with MS. The number and volume of MRI T2-positive lesions in the white matter of the brain was associated with the age of onset, duration of the disease and with the number of relapses. In several cases the phenomena of clinical-MRI dissociation was observed. Generic HLA-DRB1 genomic typing was performed in all the patients. High frequency of DR2(15) genotype in MS-affected children in comparison with the group of healthy controls was more expressed as compared with MS-affected adults. The comparison of frequencies of DRB1 alleles in transmitted, i.e. appeared in the affected child haplotypes and in non-transmitted haplotypes confirmed results of the case-control study showing the very significant association of MS with DR2 alleles and extremely significant--with its DR15 subtype in children. The data of transmission/disequilibrium test (TDT) analysis provide strong evidence for linkage of DR15 alleles and susceptibility to sporadic MS in patients with disease onset before 15 years. The positive experience of management (beta-interferon-1a) was shown in MS-affected children in three cases.

Adjuvants, Immunologic↗
PubMed1995

[Cerebrolysin in the treatment of partial optic atrophy in children].

The purpose of the trial was to investigate efficacy of cerebrolysin in children with partial optic atrophy and to compare different ways of injections of the drug. Cerebrolysin was injected in retrobulbar space and in Tenon's space. The drug was given separately and in combination with trental. Favorable effect has been achieved in all the patients treated with cerebrolysin injections in Tenon's space. In patients treated with retrobulbar injections of cerebrolysin and with injections of cerebrolysin and trental improvement occurred in 50% of cases. In control group, who did not receive cerebrolysin favorable results were achieved in 25% of patients. A 12-month follow-up study stated stability of the effect of cerebrolysin.

Amino Acids↗
PubMedDate not supplied

[Clinical assessment of infrasonic phonophoresis efficacy in the treatment of bacterial keratitis].

Therapeutic efficacy of infrasonic phonophoresis is studied in 30 patients with bacterial keratitis. Control group consisted of 87 patients with the same diagnosis. Clinical studies included comparative evaluation of the therapeutic efficacy of infrasonic phonophoresis and traditional local instillations of the same drugs. Before treatment, visual acuity was the same in both groups, while after regression of inflammation after treatment it was 0.13 higher in the phonophoresis group. Results of clinical studies indicate a higher efficacy of infrasonic therapy of patients with keratitis. The duration of therapy was decreased, number of bed-days decreased, and visual acuity after treatment improved.

Eye Infections, Bacterial↗
PubMedDate not supplied

[Organ of vision in preterm infant].

Examinations of the organ of vision in 79 preterm infants showed lack of sensitivity of the conjunctiva and cornea, unstable precorneal membrane, and insufficient lacrimal production; these features may promote the development of diseases of the anterior segment of the eyeball. Decreased reaction to a light stimulus and lack of the pupil reaction to light are characteristic features of a preterm infant. The position of the baby lying in an incubator and poor transparency of ocular media impedes the ophthalmological examination and require special training of the physician. Pathological changes in the fundus oculi of a preterm baby should be regularly checked up by an oculist during the postnatal period.

Blinking↗
PubMedDate not supplied

[Relationship between perinatal pathology and refractogenesis, incidence and type of ocular diseases in children].

Three-year-old children with a history of perinatal diseases differed from healthy age-matched children by a higher incidence of ocular diseases (78.9% vs. 21.6% in the control, p < 0.001). These children often presented with severe visual disorders: partial atrophy and hypoplasia of ocular nerves (7.2%), congenital abnormalities in the eyeball membranes (5.2%), retinopathy neonatorum (5.2%), cortical blindness (3.1%), oculomotor disorders (20.8%), and congenital deformations of the eyelids (19.7%). Disorders of refractogenesis in these children presented as a higher incidence of myopia (19.8% vs. 3.8% in the control, p < 0.001) and a shift of the percentage of refraction abnormalities towards myopia. Therefore, all children with a history of perinatal disease should be referred to a group at a high risk of ocular disease.

Child, Preschool↗
PubMedDate not supplied

[Typical difficulties of neonatologists and ophthalmologists in the treatment of infants with retinopathy of prematurity].

A perinatally, somatically, and neurologically aggravated child born at 26 weeks weighing 860 g with preterm neuropathy is described. Typical difficulties of neonatologists and pediatric ophthalmologists in the treatment of preterm babies with this grave ocular disease are described: the diagnosis cannot be confirmed by ophthalmoscopy because the optic media are not transparent, cryo- or surgical treatment has to be delayed because of severe somatic and neurological status, and intra- and postoperative complications develop despite thorough preoperative preparation.

Contraindications↗
PubMedDate not supplied

[Irrigation system "Meturakol" in the treatment of dystrophic processes of the posterior eye segment].

An original method for treating degenerative processes in the eye by means of Meturakol irrigation system is described. Studies were performed in 95 patients aged 60-70 years. Use of Meturakol irrigation system ruled out pain associated with frequent administration of drugs, ensured high concentrations of drugs in the posterior segment of the eye, and improved the efficiency of drug therapy in patients with degenerative diseases of the eyes. Good remote results are due to potent drug supply to ocular tissues and to the use of hemostatic sponge Meturakol, containing methyluracil. The method is offered for wide clinical use.

Aged↗