A study was made of the hypothalamo-hypophysio-adrenal gland interrelations during the insulin test in patients with Itsenko-Cushing disease, dyspituitrism of the puberto-juvenile period and diencephalic syndrome. The majority of the patients with Itsenko-Cushing disease displayed a reduction of insulin sensitivity, this being expressed in a delayed fall of the glucose level during the insulin test and the absence of any increase in the blood 17-OCS. An increased reaction of the hypothalamo-hypophysio-adrenal system to insulin hypoglycemia was observed in the patients with dyspituitrim of the puberto-juvenile period. A normal reaction to the insulin test was seen in all the patients with the diencephalic syndrome. The data obtained could be used in differential diagnosis between these diseases and Itsenko-Cushing disease.

17-Ketosteroids↗

PubMedDate not supplied

[The influence of adrenal cortical hormones on the state of the kinin system].

Condition of the kinin system proved to depend on the function of the adrenal cortex. An excess of glucocorticoids decreased the activity of the kinin system of the blood and kidneys. The activity of the kinin system of the blood increased in hypocorticism, whereas in the kidneys there was seen a reduction of kallikrein formation.

Addison Disease↗

PubMedDate not supplied

[Changes in the cerebral electrical activity of Itsenko-Cushing disease patients under the influence of diphenine].

For the purpose of studying the functional condition of the CNS the authors recorded the electrical activity of the brain (by the method of electroencephalography) in parallel with determination of the adrenal cortex function in patients with Itsenko-Cushing disease to whom diphenin was prescribed. Results of investigations showed reduction of the adrenal cortex function in patients with Itsenko-Cushing disease under the effect of diphenin to occur in parallel with reduction of irritation in the brain structures, detected by EEG. The data obtained confirmed an important role played by disturbances of the nervous regulation mechanisms in the appearance of this pathology.

Adolescent↗

PubMedDate not supplied

[Heterogeneity of immunoreactive prolactin in hyperprolactinemia of various origin].

Study of molecular heterogeneity of immunoreactive prolactin in patients with macro- and microprolactinomas and idiopathic hyperprolactinemia has shown heterogeneity of the total blood immunoreactive prolactin pool in all the examined patients. This pool included three basic forms with molecular masses about 23, 50, and over 100 kD (23K-, 50K-, 100K-prolactin), whose ratios essentially differed in individual patients. Physiologically the most active monomeric 23K form of prolactin predominated in the blood of patients with hyperprolactinemia due to hypophyseal micro- and macroadenomas, parallelled by manifest signs of galactorrhea and hypogonadism; the content of this form may reach 95% of the total immunoreactive hormone. Patients with hyperprolactinemia of obscure origin present with quite the contrary ratio of prolactin immunoreactive forms with the predominance of high-molecular 100K form of the hormone, whose share may reach 80-90%. Such cases of hyperprolactinemia may be associated with the absence of clear-cut clinical manifestations, including such as galactorrhea and menstrual cycle disorders, and with inefficacy of traditional therapy. Such cases were tentatively classified as 'the high-molecular prolactin syndrome' and need further research.

Adenoma↗

PubMedDate not supplied

[Bone tissue in patients with hyperprolactinemic hypogonadism].

Sixteen women with hyperprolactinemia were examined for Ca metabolism, osseous metabolism, mineral saturation of bone tissue in the thoracic portion of the spine and radius. Lowered mineral saturation of the thoracic vertebrae was detected in 69% of the examinees, that of the distal segment of the radius in 44%. Reduction of the mineral saturation of the spine was in negative correlation with the blood prolactin level and length of amenorrhea. No changes in the bone resorption biochemistry or Ca metabolism were detected. A marked reduction of blood osteocalcin level that reflects osteoblast function was detected, its blood concentration being in negative correlation with prolactin level. No relationships between mineral saturation of bone tissue, prolactin, and osteocalcin, on the one hand, and blood estradiol level, on the other, were observed. These data suggest that osteopathy in hyperprolactinemic hypogonadism is due to reduced bone formation and not to reduced estradiol production.

Adolescent↗

PubMedDate not supplied

[Malignant chemodectoma and the Itsenko-Cushing syndrome].

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Adrenal Cortex↗

PubMedDate not supplied

[Effect of large doses of reserpine on the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing's disease].

The results of study of the hypothalamo-hypophysio-adrenal system in patients with Itsenko-Cushing's disease under the influence of high reserpine doses are presented. An increase of plasma ACTH and cortizol level and disturbance of the 24-hour rhythm of their secretion was noted in the patients. High reserpine doses led to the fall of ACTH and cortizol secretion, without any normalization of their secretion rhythm in the course of 24 hours. A test with metopyron carried out before and after the reserpine prescription pointed to the increase of the ACTH reserve under the influence of high reserpine doses.

17-Hydroxycorticosteroids↗

PubMedDate not supplied

[Effect of L-DOPA administration on brain bioelectrical activity in hypothalamo-hypophyseal diseases].

The influence of the L-DOPA preparation on the bioelectrical activity of the brain was studied in 15 patients with Itsenko-Cushing's disease and in 12 patients with diencephalic obesity. L-DOPA administration caused an increase of the theta-rhythm index in the anterior leads in comparison with the initial recording, although the periods of detection of this elevation differed in various patients. No changes of the character of the EEG recording during the test with L-DOPA in comparison with the background recording was revealed in the patients with Itsenko-Cushings disease.

Adolescent↗

PubMedDate not supplied

[Patient management after bilateral total adrenalectomy].

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Acute Disease↗