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Biomedical subjects

E Hultsch

Publications and source records attributed to E Hultsch.

9 recordsLinked to original sources
PubMed1978

Effect of generalized graft-versus-host-reaction on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.

UNLABELLED: The investigations of 400 adult hybrids from A/Jax fem. BALB/c male were aimed at answering the following questions: 1. What is the influence of a generalized graft-versus-host-reaction (GVHR) on the induction and growth of benzpyren-induced sarcoma? 2. What is the behavior of B- and T-lymphocytes during GVHR, and during induction and growth of benzpyren-induced sarcoma? 3. Which are the deductions to be drawn with regard to the effect of B- and T-lymphocytes during tumorigenesis and tumor growth? RESULTS: 1. The number of tumors was significantly greater in the GVHR animals (74.5%) than in the controls (49.5%). 2. A significant decrease of T-lymphocytes and increase of B-lymphocytes during GVHR were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a marked decrease of the total round cell count and the T cells, while the count of B-lymphocytes remained uninfluenced. These results are discussed and compared with results of other authors.

Animals↗
PubMed1978

Effect of splenectomy on B- and T-lymphocytes and a benzpyrene-induced murine sarcoma.

UNLABELLED: The investigation of 400 adult mice had the objective to find out 1. The influence of splenectomy on genesis and growth of a benzpyrene-induced sarcoma and 2. The behavior of B- and T-lymphocytes under the influence of splenectomy. RESULTS: 1. A significantly lower number of tumors developed in splenectomized animals (28.5%) as compared to controls (49.5%). 2. A significant decrease of B-lymphocytes and an increase in T cells after splenectomy were found in the peripheral blood. 3. The examination of the tumor marginal zone showed a decreased number of B-lymphocytes and an increase of T-lymphocytes, while the total count of round cells remained unchanged. These results are discussed and compared with results of other authors.

Animals↗
PubMed1978

The influence of embryonal bursectomy on benzpyrene-induced sarcoma of the chicken.

160 chickens hormonally bursectomized before hatching, and 160 controls were twice given a dose of 10 mg 3,4-benzo(a)pyrene 2 weeks and 6 weeks after hatching. After 24 weeks the controls had developed muscle sarcomas at a significantly higher rate than the bursectomized animals (49.6--32.1%). The tumors were identified as malignant polymorphocellular rhabdomyosarcomas in light and electron microscopy. When the experiment was stopped after 27 weeks, the controls showed more tumors than the bursectomized chickens (65.1% versus 58.9%). The effect of bursectomy lies in a prolongation fo tumor latency. The frequency of metastases is equally decreased to a significant degree (41.7% versus 21.7%). These results are interpreted as an illustration of the disturbed equilibrium between the T and B cell responses.

Animals↗
PubMed1977

Bursa-independent plasma cells in the Harderian gland of the chicken (Gallus domesticus). Histomorphometrical investigations.

Morphometric investigations of the Harderian gland in normal and bursectomized chickens at the 16th, 30th, and 60th day after hatching, show a significcant suppressive effect of bursectomy on the volume of the plasma cell compartment in this organ. However, the suppression of the plasma cell population in the Harderian gland is not complete. The plasma cells remaining in the Harderian gland after bursectomy are probably components of a bursa-independent B cell population.

Animals↗
PubMed1977

Peripheral uveitis in the owl monkey. Experimental model.

Primary intravitreous HA injections cause a great variation in ocular inflammatory response, ranging from slight Tyndall effect (LI-HA) to severe inflammation (HI-HA). Both slight and severe inflammation are transient and subside completely within 10-30 days (early inflammatory response), whereas multiple injections ( greater than 3 times) cause a peripheral uveitis, which can be of interest as an experimental model. Control experiments with endotoxin (endotoxin uveitis) fail to produce the same or similar pathological alterations.

Animals↗