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Biomedical subjects

E Housset

Publications and source records attributed to E Housset.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Quantitative assessment of labial salivary gland sclerosis in patients with diffuse scleroderma (author's transl)].

Biopsies of the lips were performed on 27 patients (7 male and 20 female; mean age, 58 years) with diffuse scleroderma and on 10 healthy subjects serving as controls. The degree of intralobular sclerosis in labial salivary glands was measured on tissue sections by an automated morphometric analysis technique. Collagenous compared with controls. It was independent from the type of cell infiltrating the gland and from the evolution potential of the disease, but it correlated with its duration and seemed to be specific to scleroderma.

Adult↗
PubMed1981

[Evaluation of the spread of atherosclerosis in patients with arteritis. Implications for the therapeutic indications (author's transl)].

The immediate prognosis (operative risk of a revascularization) and also the long-term prognosis for the patient with arteritis depends on the spreading of the atheroma to other vascular regions (coronary or carotid arteries). Conventionally the initial evaluation is made by cervical Doppler examination, effort ECG and profile aortography. Cervical Doppler examination revealed in the present group of 402 patients significant stenoses on the arterial vessels leading to the brain in 67 cases (16.6%), including 13 asymptomatic stenoses. The effort ECG carried out in 140 cases was assurable in 72% of these, being positive in 19% of the cases in patients with no clinical or ECG history of coronary insufficiency. Profile aortography of 125 patients revealed atheromatous lesions in 39 (31%), in many cases multiple lesions: 13 cases in the coeliac trunk and mesenteric artery. The implications of these discoveries, as they affect therapeutic indications and in particular the justification of multiple revascularizations, have been discussed.

Angiography↗
PubMed1981

[Diffusion of atherosclerosis in patients with arterial disease of the lower limbs (author's transl)].

In patients with arteriosclerosis obliterans of the lower limbs immediate (operative risk) and long term prognosis depend on the diffusion of the atheroma to other arterial beds (coronary and carotid). Basic investigations were completed by doppler ultrasonography of the cervical arteries, exercise electrocardiogram and lateral aortogram. Doppler ultrasonography revealed significant degrees of stenosis of the cervical arteries in 67 out of 402 patients (16.6 p. 100). The stenosis were totally latent clinically in 13 patients. Valid results were obtained in 72 p. 100 of 140 after an exercise electrocardiogram. It was positive in 19 p. 100 of patients without clinical or electric sign of coronary heart disease. Lateral aortogram in 125 patients showed atheromatous lesions in 39 cases (31 p.cent). These were often multiple and involved the coeliac and superior mesenteric arteries in 13 cases. These investigations are of great importance in making the therapeutic decision, indications related with risk and resulting priorities. Alarming coronary or carotid lesions may indeed require treatment before arterial disease of the lower limbs.

Aortography↗
PubMed1980

[Current aspects of the treatment of deep venous thromboses by heparin (author's transl)].

The use of heparin by continuous infusion from a electric pump gives very good immediate results in the treatment of venous thromboses. In 58 patients, there was a constant improvement in clinical signs and recurrence of the venous thrombosis was exceptional (2%), pulmonary embolism rare (3.5%) and well tolerated. Constant flow and the surveillance of treatment led to the method ensuring stable blood heparin levels. Mid-term results (8 months) in 43 patients appeared to be less favourable, the prevalence of venous sequelae reaching 50% for iliac phlebitis, 28% for sural phlebitis. The respective advantages and disadvantages of heparin and fibrinolytic agents are discussed.

Adult↗
PubMed1980

Effects of in vitro and in vivo exposure to insulin upon glucose carbon accumulation in rat aorta: different patterns of response for intima-media and adventitia.

We have studied the effect of insulin upon the accumulation of glucose carbon into the intima-media and the adventitia of rat aorta following in vitro exposure by adding insulin to the incubation medium, and in vivo exposure by producing relative hyperinsulinemia during life and subsequently incubating excised tissue in a medium containing no insulin. Hyperinsulinemia in vivo was either (1) endogenous--following 1.5-2 hr of refeeding after a 48-hr fast--or (2) exogenous--following an i.v. injection of insulin. For adventitia, a significant stimulation was found after both in vitro (+ 53%, p < 0.001) and in vivo exposure to insulin (+ 96%, p < 0.01 with endogenous insulin; + 75%, p < 0.05 with a dosage of 2 U/kg of exogenous insulin). For intima-media, the stimulation was weak and insignificant after in vitro exposure (+ 11%, p > 0.30), but became important and significant after in vivo exposure to insulin (+ 100%, p < 0.001 with endogenous insulin; + 50%, p < 0.05 with a dosage of 0.5 U/kg and + 49%, p < 0.05 with a dosage of 2 U/kg of exogenous insulin). For the in vivo exposure experiments, we found a significant linear correlation (r = 0.611, p < 0.005) between plasma insulin concentrations and glucose carbon accumulations into intima-medias of control and refed rats. These results establish the insulin sensitivity of the adventitia and show a sensitivity of intima-media only to in vivo insulin exposure. These different behaviors of intima-media in vivo and in vitro may have a hemodynamic basis.

Animals↗
PubMed1980

Local urokinase in arterial thromboembolism.

Selective intra-arterial urokinase (UK) is effective in treating recent arterial thromboembolism. However, usually only partials lysis is achieved and this treatment seems less effective than intravenous streptokinase. At a dose of 37,500 UCTA/hour it does not produce systemic fibrinolysis. This protocol substantially reduces the risk of systemic bleeding and embolism and extends its applicability to operative patients. The combination of surgery and UK seems particularly promising in patients with atherosclerotic arterial thrombosis.

Adult↗
PubMed1980

[Severe ischemia of the lower limbs after ingestion of LSD].

A case of severe limb ischaemia predominating in the legs in a young female drug addict is reported. Arteriography revealed diffuse spasm of all arteries of the lower limbs associated with localised spasm along the profunda artery in particular. These appearances regressed on control angiography performed 10 days later. The treatment which associated volume expanders and intravenous vasodilatation agents (magnesium sulphate) led to rapid improvement in the clinical condition in 3 days. There were no long-term complications. The causative role of LSD was suggested by the history of greatly increased intake in the period before the onset of symptoms. LSD is a derivative of lysergic acid, the common nucleus of the derivative of the ergot of rye. Analysis of a sample dose taken by the patient showed a very large quantity of LSD and of lysergic acid and a very small amount of other ergot alkaloids known for their peripheral vasoconstrictor effects. The circumstances following peripheral ischaemia are discussed; the association of haschich - LSD does not seem to be a factor. The increased doses and a predisposed vascular system, in common with ergot containing drugs, seem to be the major factors.

Acute Disease↗
PubMed1980

Tumor incidence and development of autoimmune hemolytic anemia in two breeding lines of the NZB mouse strain that differ in chromosome breakage.

Increased chromosome breakage observed in NZB mice was studied. Breeding experiments with mice selected according to breakage frequencies provided evidence that the proportion of mice with high breakage (HB) and low breakage (LB) figures in the progeny depends on the phenotype of the parents. Selective breeding for the "chromosome breakage" characteristic was successful and resulted in the separation of a breeding line with LB incidence. However, the selection could not be continued beyond the fourth generation for the mice with HB incidence because of lethal factors. Comparative studies of HB mice from the HB line and LB mice from the LB line showed significant differences for tumor incidence and positivity of the Coombs' test.

Age Factors↗
PubMed1980

[Thombosis of a persistent sciatic artery: a rare cause of severe ischemia in the lower limb (author's transl)].

Persistence of the primitive axial limb artery is an uncommon developemental anomaly. This artery is called sciatic in account of its connections with the nerve. Usually gluteal aneurysms develop and the anomaly is disclosed by a complication : pain, pulsatile buttock mass, thrombosis or release of emboli. Prophylactic surgical repair of such aneurysms seems reasonable.

Aged↗
PubMed1979

[Does the hepatitis of secondary syphilis exist? Two cases (author's transl)].

Two patients are presented as new cases of secondary syphilitic hepatitis. The closely resemble descriptions in the literature with the same clinical and laboratory "profile" and the same course spectaculary influenced by anti-syphilitic penicillin therapy. The presence of treponemes in the liver, which would definitely confirm the diagnosis, was not demonstrated. This is a particularly important diagnosis, which should not be missed since it leads to treatment of fundamental importance to the patient's future.

Adult↗