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Biomedical subjects

E Housset

Publications and source records attributed to E Housset.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Value of arteriography in the exploration of subungual glomus tumors. Apropos of a case].

Difficulties in the diagnosis of subungual glomus tumors are increased when clinical examination and standard radiographic images are normal. In these cases arteriography is a useful procedure, opacification in the arterial phase of a small vascular lake confirming the diagnosis and localizing the lesion. A case is described that illustrates the interest of this examination, although it is indispensable only in patients with glomus tumors of atypical clinical expression or when symptoms recur after excision.

Adult↗
PubMed1985

[Biological profile of the 1st 4 hours of a thrombolytic treatment combining urokinase with lysyl-plasminogen].

The authors study the biological variations which accompany an oral, thrombolytic treatment in which urokinase and lysyl-plasminogen are combined. Fibrinogen, the products of degradation of fibrinogen or fibrin, plasminogen and rapid alpha 2 antiplasmin are studied as a function of time. Two dimensional electrophoreses were carried out at precisely determined times. The combination of the two therapeutic agents causes the appearance of plasmin in the circulation, but it is neutralised by its rapid inhibitor. This therapeutic protocol entails moderate circulating fibrinolysis and may easily be monitored by determination of the circulating fibrinogen.

Acute Disease↗
PubMed1985

Relationship between nailfold capillary microscopy and salivary capillary basement membrane width in Raynaud's disease and progressive systemic sclerosis.

To assess the relationship between a nailfold scleroderma pattern and histopathological data, we compared the results of nailfold capillaroscopy with capillary basement membrane width of labial salivary glands in 25 patients with either a Raynaud's disease (RD: 12 patients) or a progressive systemic sclerosis (PSS: 13 patients). The sensitivity of a capillaroscopic scleroderma pattern for capillary basement membrane thickness is of 75%. These results confirm the usefulness of in vivo capillary examination for the early diagnosis of PSS.

Adolescent↗
PubMed1985

[Raynaud's syndrome in lumberjacks using chain saws. Epidemiology, clinical and capillaroscopic findings].

The overall incidence of Raynaud's syndrome in lumberjacks using a mechanic chain saw in France is at least 45%; workers exposed to the risk for more than 3 years have an incidence of about 60%. Vibrations are probably directly responsible for the disease, while among the other favorizing factors the different winter climatic conditions do not appear to be relevant, and this is the case with conventional vascular risk factors, apart perhaps for hypertension. A history of injury to hands is significantly more frequent in affected subjects possibly related to a relative digital cutaneous hypo-esthesia. Capillaroscopy shows organic microangiopathies with reduction in number of nail-bed capillaries and functional angiopathies of arteries of hand in the form of abnormal spasm induced by cold. Technical progress by the use of chain saws has markedly reduced incidence of this occupational disease, but in France it would appear that only modifications in working conditions of lumberjacks could reduce the incidence of the disease.

Capillaries↗
PubMed1984

[Transcutaneous measurement of oxygen partial pressure. A new method for functional study in vascular pathology].

A polarographic electrode was used for non-invasive transcutaneous measurement of partial oxygen pressure (PO2, oxygen tension) in healthy subjects (controls) and in patients with arteritis. The mean oxygen tension value on the dorsum of the foot in controls (n = 32) was 67.9 +/- 8.1 mmHg; individual values were inversely correlated with age and were distributed along a gaussian curve; mean differences on repeated measurements were 4 mmHg at 3 hours and 7.3 mmHg at 24 hours, which is extremely good. Patients with arteritis (n = 43) had a mean oxygen tension value of 41.5 +/- 20.7 mmHg; after adjustment for age the difference was significant (p less than 0.001). Oxygen tension values in patients with intermittent claudication were not different from those found in controls, but they were lower in patients with gangrene and with pain on decubitus. In the diagnosis of cutaneous ischaemia, the sensitivity of the test was 96%, its specificity 82%, its positive predictive value 79%, its negative predictive value 96% and its reliability 89%. These results suggest that the method will be increasingly used in vascular pathology.

Adult↗
PubMed1984

[Intra-arterial thrombolysis with the combination of urokinase and lysyl-plasminogen. 27 cases of acute arterial obliteration of the lower limbs].

Twenty-five in situ thrombolysis using Lysyl Plasminogen and low doses of urokinase were performed on 25 acute, recent and severe arterial occlusion of lower limbs. Early success were 56% and 44% with a follow up of 5 months. Complications were very limited. Thus the thrombolytic treatment used in this study appears as effective as locally administered streptokinase but higher tolerated. It seems to be able to win one of the best places in the treatment of the arterial disease of the lower limbs.

Acute Disease↗
PubMed1984

Fine structural capillary changes and basal lamina thickening in scleroderma (progressive systemic sclerosis) and Raynaud's disease.

Capillary abnormalities were found by electron microscopy in labial salivary gland biopsies obtained from 20 patients with progressive systemic sclerosis (PSS). They consisted of marked thickening and multilayering of basal lamina, degenerative and adaptative endothelial cell changes, alterations of pericytes and perivascular mononuclear cell infiltration. There was no correlationship between the intensity of the capillary abnormalities and the duration of the disease. In 12 patients with Raynaud's disease (RD) such changes were not found. Thus capillaries displayed normal-looking ultrastructural appearances. Mean capillary basal lamina width was consistently thicker in the PSS group than in the RD group (p less than 0.001). These observations are consistent with the hypothesis that the primary event in PSS occurs in the microvessels. It is suggested that labial salivary gland biopsy may be helpful for early recognition of PSS among subjects with Raynaud's syndrome.

Adolescent↗
PubMed1984

Diabetes and insulin: actions and interactions upon the glucose metabolism of rat aorta.

We studied the glucose oxidation to CO2 and the incorporation of glucose into lipids by thoracic aorta from streptozotocin-diabetic rats in two circumstances: 9 minutes exposure of the isolated aorta to insulin, perfused in situ; and one-week treatment with either low--4 units (U)--or high--12 U--daily doses of insulin. Diabetes inhibited the glucose metabolism of media and adventitia. Perfusion with insulin did not influence the depressed metabolism of media but increased that of adventitia. Four units insulin treatment normalized the synthesis of glucose-derived lipids by the media, whereas 12-U treatment brought it to levels significantly higher (+23%) than those found in nondiabetic rats. We conclude that: (a) a haemodynamic explanation cannot account for the in vitro insulin resistance of media found in diabetes; (b) insulin treatment exerts a dose-dependent lipogenic effect upon the media, which might favour an atherogenic role for therapeutic hyperinsulinaemia in insulin-dependent diabetics.

Animals↗
PubMed1984

[Sclerodermal microangiopathy: a cause or a consequence?].

Microangiopathy is an essential clinicopathological feature of systemic scleroderma, comprising capillary thinning, thickening of the basement membrane and abnormalities of the endothelium which has an abnormally high uptake of radioactive thymidine. The identification of a circulating cytotoxic factor for endothelial cells suggests that the microangiopathy may play a role in the physiopathogenesis of the disease. In practice, microangiopathy can be fully assessed by capillaroscopy in patients with systemic scleroderma.

Capillaries↗
PubMed1984

[Hemodynamic response of the digital artery to heat and cold in normal subjects, in systemic scleroderma and in Raynaud's disease].

Measurement of digital systolic pressure under hot and cold conditions provides objective data (in mm Hg) of the humero-digital gradient and of spasm induced by cold. Normal values are: digital systolic pressure at 30 degrees C: 94 +/- 12% of humeral systolic pressure; at 15 degrees C: 94.46 +/- 9.32%, and at 10 degrees C: 93.6 +/- 12% of digital systolic pressure at 30 degrees C. The significance of these two parameters resides in the fact that the humero-digital gradient is of etiological value in organic arterial disease, the specificity of the test being 94.4% in allowing distinction between Raynaud's disease and systemic sclerosis. The cold-induced spasm can provide quantitative evaluation of a clinical Raynaud's phenomenon with which it is correlated (specificity: 96%).

Adolescent↗
PubMed1984

[Cutaneous lymphangioma. Value of the scanner. Pathogenic hypothesis and therapeutic implications].

The authors report the case of a 10-year-old child with a cutaneous lesion of the thigh present since birth and made up of small translucid raised areas grouped in clumps. The association with these pseudo-vesicles of erysipelatous exacerbations 3 or 4 times a year and the discharge of clear fluid indicative of lymphorrhoea led to a clinical diagnosis of complicated cutaneous lymphangioma. CT scan of the thigh showed absence of spread to deeper layers. This case serves as a basis for discussion of the pathogenic hypothesis of Whimster suggesting that the superficial vesicles are connected to larger lymphatic chambers in the subcutaneous tissue and that the course depends upon pressure variations within these chambers. If this were the case, surgical excision of these lymphatic chambers would be a logical alternative to symptomatic medical treatment of inflammatory episodes.

Child↗
PubMed1983

[Systolic arterial hypertension in patients amputated for injury].

The blood pressure of 106 men who had undergone amputation of one limb on account of war injury was compared with that of 184 male controls of the same ages. All subjects with a diastolic pressure above 90 mmHg were excluded from the study. The diastolic pressure was statistically equivalent in both groups, but the amputees had a significantly higher systolic pressure. Changes in the visco-elastic properties of the arterial system related to amputation might be responsible for this rise in systolic pressure.

Adult↗