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Biomedical subjects

E Hokkanen

Publications and source records attributed to E Hokkanen.

At least 37 records · Page 2Linked to original sources
PubMed1979

Brachial plexus and radicular neurography in relation to cortical evoked responses.

An application of somatosensory potential recording suitable for clinical neurodiagnostics is described. Evoked responses were recorded with surface electrodes at four levels between wrist and scalp: Erb's point, seventh cervical spine, inion, and the somatosensory area of the scalp. The normal latency and latency difference values based on 16 healthy subjects are presented as well as those of four examples of pathological cases with lesions at various levels in the nervous system. The method presented offers novel possibilities for solving problems of differential diagnosis, especially at the level of the brachial plexus.

Adult↗
PubMed1979

Juvenile amyotrophic lateral sclerosis. A report of two cases in a single family.

This paper presents two juvenile cases of familial amyotrophic lateral sclerosis. They are the first and fourth child in a family with seven children from the eastern part of Finland. All seven children, as well as the parents, were examined by our group. In the first case the disease showed a rather mild course, while in the second a noticeable progression was observed even during a period of 10 months. The patients come from a rural area with a stable population and low immigration, which may favor an enrichment of certain genes and therefore support the possible hereditary basis for the disease.

Adolescent↗
PubMed1978

Evaluation of the jitter phenomenon in myasthenic patients and their relatives.

Single fiber electromyography with jitter measurements and blocking evaluation was used for investigating 23 myasthenic patients, their 29 healthy relatives, coming from 10 families, and a control group of 10 subjects. Blocking was never seen in the healthy controls, and the jitter averaged some 30 microsec. Blocking was present in the myasthenic patients in 25.4% of the recorded potential pairs and there was a pathological jitter, which often extended over a few hundred microsec. The records of ten healthy relatives of patients were suggestive of slight but unquestionable abnormalities of neuromuscular transmission, viz. blocking and a jitter of over 60 microsec or more. The results demonstrate subclinical derangements of neuromuscular transmission in families of myasthenic patients, which points to a familial factor as involved in the pathomechanism of the disease.

Adolescent↗
PubMed1978

Effect of a slow release preparation of levodopa on Parkinson's disease in combination with a peripheral decarboxylase inhibitor.

Plasma concentrations of levodopa were determined after therapeutic oral levodopa-carbidopa doses. The wide fluctuations observed in plasma levodopa levels could be considerably reduced by the addition of a slow release levodopa preparation. This kind of combination medication was given to 15 parkinsonian patients, whose earlier therapy had proved inadequate. With the combination medication, levodopa-carbidopa, on an average 420 mg/42 mg combined with 950 mg of levodopa in slow release form, a statistically significant improvement in parkinsonian signs could be achieved without any worsening of the side effects. The results suggest that parkinsonian patients may tolerate much higher daily levodopa doses if the fluctuations in plasma levels of the drug can be diminished.

Adult↗
PubMed1978

Measurement of reference values for certain proteins in cerebrospinal fluid.

Reference values are presented for certain cerebrospinal fluid proteins and related indexes, based on determinations carried out on 46 patients with diffuse lower back pain using radial immunodiffusion and electroimmunoassay. A sex difference was noted in total protein and albumin values. The electroimmunoassay method with its sensitivity enhanced by the use of Coomassie Blue staining and optimal antiserum concentrations enabled a reference value to be determined for IgA in cerebrospinal fluid.

Adult↗
PubMed1978

Recurrent multiple cranial neuropathies.

A report of 12 patients with recurrent multiple cranial neuropathy is presented. In most cases the palsies a accompanied a mild respiratory infection. Both motor and sensory cranial nerves were affected, the facial nerve and optic nerve being the most common. The symptoms were self-limited in course and steroid therapy seemed to hasten the recovery in the cases it was used. Only in a few cases a noticeable neurological deficiency remained. Aetiological aspects of the syndrome are discussed.

Adult↗
PubMed1978

[Ergotamine].

Explore the source record for details and available documents.

Animals↗
PubMed1977

Social aspects in myasthenia gravis.

The myasthenics in Finland (n = 240) have been registered and treated in one center for more than 10 years. Of this material, an investigation was performed of their medico-social state as of 1 January, 1975. The study comprised 88 per cent (210) of the patients. In the working age (16-64 years) were 181 patients. Compared to the total Finnish population, the myasthenic patients lived more often in urban districts, had had more intermediate-school and university--but less vocational-school education, and belong as a whole to "higher" social classes. The severity and the variability of the disease naturally influenced the disability. A change from severe to slight symptoms occurred in 38 per cent, and 12 per cent of the myasthenics were in complete remission (2/3 of whom had had severe symptoms). One third (72) got a full pension because of myasthenia, and about one tenth (25) because of some other reason. Of these who got a full pension for myasthenia, 7 per cent were in complete remission without any myasthenic symptoms. The influence of thymectomy on the degree of disability was impressive, since more than 50 per cent of disabled myasthenic patients returned to work thereafter. Thus, because of the unpredictable, but on the long term quite favourable course, a full pension should not be prescribed early (during the first 5 years) of the disease. An active treatment may also change the outlook for even the most severely disabled patients.

Adolescent↗