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Biomedical subjects

E Hoffmann

Publications and source records attributed to E Hoffmann.

At least 181 records · Page 10Linked to original sources
PubMed1990

[Electrocardiographic indices of reperfusion and limitation of the necrotic area in acute myocardial infarct].

The aim of this study was to assess the evolution of ST segment displacement and the formation of new Q waves in relation to the late angiographic demonstration of recanalization of the infarct-related vessel in 36 patients with acute myocardial infarction admitted in our Institution within 8 hours from the onset of symptoms. Eighteen patients were treated with intravenous urokinase (200,000 + 1,200,000 UI) followed by sodium-heparin 1,000 U/ev/hour for 48 hours and calcium-heparin 3,000 UI/10 Kg/12 hours from the third day to discharge. Eighteen patients were treated from admission only with calcium-heparin as seen before. All the patients have been followed with serial electrocardiograms; we evaluated the sum of ST displacements (ST12) and Q waves score (Q12) in the 12 standard leads on admission, and on the twelfth, twenty-fourth, forty-eighth hour, and on discharge. On the basis of the late angiographic findings and apart from the treatment, we divided the patients into 2 groups: patients with recanalization of infarct-related vessel (20 patients, 55.5%) and patients with occlusion of the infarct-related vessel (16 patients, 44.6%). We did not observe statistically significant differences between the 2 groups for decrease of ST segment displacement of formation of new Q waves, even if reperfused patients showed a more rapid and complete decrease of ST segment displacement and a more rapid formation of new Q waves with respect to occluded patients. Our data indicate that from a clinical point of view electrocardiographic indices are not a sensitive marker of recanalization of infarct-related vessel.(ABSTRACT TRUNCATED AT 250 WORDS)

Angiography↗
PubMed1989

[Possibility of early diagnosis of diabetic nephropathies].

The serum and urine level of beta-2-microglobulin was examined by the authors in different stages of nephropathy of 250 patients suffering from diabetes mellitus (I type 178 pts, II type 72 pts). Beta-2-microglobulin values measured in diabetic patients without renal microangiopathy did not show any difference compared with that of the controls. In patients with freshly discovered diabetes mellitus significantly decreased beta-2-microglobulin levels were found, probably due to the increased glomerular filtration rate. Increasing beta-2-microglobulin values indicating an early glomerular lesion--were observed in incipient diabetic nephropathy. These values were significantly higher compared with that of healthy individuals and diabetic patients without renal microangiopathy. In the IV stage of disease the serum and urine beta-2-microglobulin levels were equally found to be elevated, indicating an impaired function of proximal tubuli beside the vascular lesions. The most expressed beta-2-microglobulin value elevations were observed in the stage of nephropathy. The authors emphasize the importance of determination and common evaluation of 24 hours protein excretion and serum urine beta-2-microglobulin values the earliest diagnosis of incipient renal lesion. According to their results, the introduction of this method may be very useful for early indication and follow-up of specific renal complications in diabetes mellitus patients.

Diabetes Mellitus, Type 1↗
PubMed1989

A randomised study of central versus peripheral intravenous nutrition in the perioperative period.

Out of 60 patients undergoing surgery for colo-rectal cancer, 30 were given total parenteral nutrition (TPN) via a peripheral venous catheter (PVC), and 30 via a central venous catheter (CVC). All Patients were treated for 10 days perioperatively. There were no complications of the treatment by CVC. The treatment had to be interrupted in 11 (= 37%) of those receiving TPN via PVC, 4 because of general inconvenience, 7 because of transient pain in the infusion arm without any sign of phlebitis. 63% suffered no complications. The study shows that, with most patients, it is possible to give TPN with an osmolality around 1100 mOsm/kg for up to 10 days via peripheral veins. For TPN of short duration, or where the duration of treatment is uncertain, it is recommended to give TPN initially via peripheral venous catheter, unless a central venous catheter is indicated for other reasons.

Journal Article↗
PubMed1989

Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline.

The effect of the monoamine oxidase inhibitor selegiline on tyramine metabolism and intravenous and oral tyramine pressor sensitivity was studied in healthy subjects. After oral doses of tyramine, which caused systolic blood pressure to increase by 30 mm Hg, we determined plasma concentrations of p-hydroxyphenylacetic acid (HPAA) and of conjugated and unconjugated tyramine. When 20 mg/day of selegiline was administered, the AUCspec of HPAA decreased from 86% to 64% and the AUCspec of conjugated tyramine increased from 13% to 35% of the sum of total tyramine and HPAA. Pressor sensitivity was enhanced more with oral administration of tyramine than with intravenous administration of tyramine. After the drug was discontinued, initial values were reached within 4 days (one subject) and 2 weeks (two subjects). Fifty-five percent of the selegiline dose was eliminated in urine as amphetamine and methamphetamine. The findings support the assumption that selegiline does not selectively inhibit monoamine oxidase-B (MAO-B) when administered in doses of 20 mg/day and higher.

Administration, Oral↗
PubMed1989

[Aggressive abdominal fibromatosis: the place of diagnostic imaging].

Aggressive fibromatoses are locally invasive, non-metastasising, fibroblastic soft-tissue tumours. On the basis of examinations made in 6 patients with histologically confirmed diagnosis, the reliability of different imaging modalities in preoperative diagnosis and in follow-up is discussed. The inhomogeneous tumour composition was evident in all imaging procedures. Computed tomography offered the highest sensitivity for tumour detection and proved accurate in demonstrating the characteristic radial tumour spreading of mesenteric aggressive fibromatosis; the attenuation values ranged from 18 to 58 HU. in pre-contrast CT scans. In magnetic resonance imaging the tumours mostly produced a low signal in T1- and T2-weighted sequences; the calculated T2-relaxation times ranged from 97 to 186 ms.

Abdominal Muscles↗
PubMed1989

[Removal of Zenker's diverticula using automatic staplers].

Own experiences with the resection of pharyngoesophageal (Zenker's) diverticula using a stapling device are reported and compared with the rare literature. No patient developed a leakage or a stenosis after surgery. All patients were free of symptoms after the operation and no patient died due to surgery.

Aged↗
PubMed1989

[Amiodarone-induced segmental lung infiltration. Radiologic and computed tomographic aspects].

Due to pulmonary toxicity, segmental lung consolidation or diffuse interstitial pulmonary infiltrations can occur during long-term treatment of ventricular tachycardia with amiodarone (Cordarex). These infiltrations can be confused with other infectious pneumonic consolidations, dystelectasia or tumorous lung disease, and may be erroneously treated as such. Apart from the clinical symptoms (dyspnea, non-productive cough, low-grade fever), the earliest radiographic signs are segmental infiltrates or diffuse interstitial lung opacifications. Pathological pulmonary function tests can only be observed in the early stages of the diffuse alveolar-fibrosing form of the disease. In this case study of amiodarone-induced segmental pulmonary infiltration, the radiological and computer-tomographic aspects are discussed, along with other complementary diagnostic procedures such as gallium scintigraphy and bronchoscopic biopsy.

Amiodarone↗
PubMed1989

[Modification of blood coagulation by the anti-arrhythmia drug prajmalium bitartrate in vivo].

We studied the effects of prajmaliumbitartrate (PBT, Neo-Gilurytmal, Giulini Pharma, Hannover, FRG), an antiarrhythmic drug on some parameters of blood coagulation in patients. PBT, 20 mg given three times a day, significantly prolonged template bleeding time and ex vivo thrombus formation time in a modified Chandler's loop. Ex vivo platelet aggregation using different agonists and tests of the plasmatic coagulation system remained unchanged.

Ajmaline↗
PubMed1988

Two-dimensional 1H-NMR investigation of ribonuclease T1. Resonance assignments, secondary and low-resolution tertiary structures of ribonuclease T1.

Ribonuclease T1 was studied by two-dimensional 1H-NMR spectroscopy. Resonance assignments were obtained for the backbone protons of 95 amino acid residues and most of its side-chain protons using sequence-specific assignment procedures. The secondary structure elements of ribonuclease T1 were identified by an investigation of medium- and long-range nuclear Overhauser effects between the backbone and C beta protons. A low-resolution three-dimensional structure of ribonuclease T1 was deduced from qualitative interpretation of long-range nuclear Overhauser effects.

Amino Acid Sequence↗