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Biomedical subjects

E Hodak

Publications and source records attributed to E Hodak.

At least 73 records · Page 4Linked to original sources
PubMed1990

A possible case of drug-induced familial pemphigus.

Two sisters developed pemphigus vulgaris and pemphigus erythematosus within 3 years. The diagnosis was confirmed by clinical, histologic and immunofluorescent antibody studies. One of the sisters experienced a common cold before the pemphigus developed and displayed a positive macrophage migration inhibition (MIF) test to a combination drug compounded of paracetamol, caffeine, chlorpheniramine maleate and phenylephrine HCl, which she had received 2 weeks prior to the appearance of the cutaneous lesions. It is suggested that her pemphigus was triggered by the drug. Although the patient had a strong genetic and familial predisposition to pemphigus, her clinical symptoms did not become evident until they were activated through an exogenous factor, namely, the causative drug. This case offers an example of a possible interaction between endogenous, genetic factors, and exogenous, triggering factors in the development of full-blown disease.

Acetaminophen↗
PubMed1989

Pityriasis rotunda in a Caucasian woman from the Mediterranean area.

Pityriasis rotunda (PR) has been known to affect, almost exclusively, Japanese and South African Bantu, often in association with various systemic diseases. However, the occurrence of PR in Caucasian patients is extremely rare, and has been previously described in only three reports. We hereby report a case of an apparently healthy Caucasian woman from Israel having clinical and histological features characteristic of PR. Pityriasis rotunda (PR) is a rare disorder of keratinization characterized by strikingly well demarcated, perfectly round scaly brownish patches of variable number and diameter located mainly on the trunk and extremities. The exact place of this disorder within the nosology of the cutaneous dermatoses is not yet fully established. However, most authors regard it as a special circumscribed form of acquired ichthyosis with a histological resemblance to ichthyosis vulgaris. For more than half a century following the first description of this disorder in 1906 cases reported were almost exclusively from the Far East, particularly from Japan, or in South African Negroids, with a few cases of West Indian Negroids, usually in association with various debilitating diseases. The first report of a Caucasian patient appeared in the literature in 1966 and since then there have been only two additional reports of PR in Caucasian patients.

Adult↗
PubMed1988

Electromyographic abnormalities in patients undergoing long-term therapy with etretinate.

Neuromuscular evaluation including electromyographic studies and serum muscle enzyme level determinations were performed in 13 patients who had been receiving etretinate for 1 to 2 1/2 years. None of the patients had complained of muscle pains or weakness. In 3 of 13 patients the electromyographic studies showed low amplitude and short duration action potentials. Mild muscular weakness was detected in one of these three. The levels of serum muscle enzymes were within the normal range in all patients. Results suggest that etretinate may cause subclinical muscle damage. In view of our results and previous reports, it seems that neuromuscular evaluation should be part of the routine follow-up of patients receiving long-term therapy with etretinate.

Action Potentials↗
PubMed1987

Nodular secondary syphilis mimicking cutaneous lymphoreticular process.

We hereby report a case presenting a rare form of secondary syphilis with an unusual nodular eruption accompanied by pruritus and generalized lymphadenopathy, bearing a striking resemblance to lymphoma. The histologic picture was also misleading and was compatible with lymphocytoma cutis. The diagnosis was eventually made after results of serologic tests for syphilis were found to be positive, with an extremely high titer of VDRL, and dark-field microscopy had demonstrated spirochetes in a nodular lesion. Secondary syphilis should thus be considered in the differential diagnosis of nodular lesions resembling lymphoreticular disease. It is also suggested that syphilis be added to the list of diagnoses belonging to the category of pseudolymphoma.

Aged↗
PubMed1987

Etretinate-induced skeletal muscle damage.

Three patients who received etretinate, two for psoriasis vulgaris and one for exfoliative dermatitis, developed clinical and electromyographic features of muscle damage during treatment. In one patient histological and ultrastructural findings indicated segmental muscle necrosis. Withdrawal of the drug led to clinical recovery and normalization of muscle enzyme levels and electromyogram. To the best of our knowledge, this is the first report to show etretinate-induced reversible skeletal muscle damage.

Adult↗
PubMed1987

Etretinate treatment of the nevoid basal cell carcinoma syndrome. Therapeutic and chemopreventive effect.

A patient suffering from the nevoid basal cell carcinoma syndrome, in whom various surgical and conservative treatment modalities had been tried previously, was placed on oral etretinate therapy. A therapeutic effect of the etretinate on existing basal cell carcinomas and a prophylactic effect in inhibiting new tumor formation were well demonstrated during the 13-month period of treatment.

Basal Cell Nevus Syndrome↗
PubMed1987

The heterogeneity of tumours associated with epidermodysplasia verruciformis.

A patient with epidermodysplasia verruciformis also had lesions of seborrheic keratosis, irritated seborrheic keratosis, and intraepidermal and invasive squamous cell carcinoma as well as infiltrating squamous cell carcinoma associated with eccrine poroma. Electron microscope studies revealed intranuclear virus particles. Immunoperoxidase studies using rabbit anti-bovine papilloma virus serum showed a positive reaction.

Adenoma, Sweat Gland↗
PubMed1986

Palmoplantar eruption associated with etretinate therapy.

Five psoriatic patients developed papular lesions of palms and soles, shortly after beginning treatment with etretinate. Histological examination in two cases was insignificant. The lesions disappeared without tapering the dose of etretinate. The fact that lesions appeared and subsided within a short period may explain why this unusual adverse reaction of etretinate therapy has not been reported previously.

Adult↗
PubMed1986

Palmoplantar keratoderma in association with myxedema.

A 63-year-old female who had been suffering from intractable palmoplantar keratoderma for 13 years was found to have myxedema. Shortly after institution of substitution therapy with thyroid hormone there was a striking improvement in her condition. The possibility of a causal relationship between hypothyroidism and hyperkeratosis is suggested.

Biopsy↗