Search PubMed⌕ Search

Biomedical subjects

E Hirsch

Publications and source records attributed to E Hirsch.

At least 235 records · Page 13Linked to original sources
PubMed1977

Dietary-induced overeating in experimental animals.

Modifications in dietary conditions can result in small, but consistent, increases in caloric intake which over time accumulate to substantial increases in body weight. Allowing rats access to either high fat diets or a variety of highly palatable foods can lead to obesity. Recent experiments also have shown that providing access to sweet carbohydrate solutions in addition to the complete diet can cause weight gains in normal neurologically intact adult rats. Although animals increase consumption of carbohydrate on this dietary regime, they continue to maintain minimum requirements for other dietary nutrients. It appears that increasing the palatability of the diet can lead to overeating, but cannot induce the rat to select a diet that is deficient in protein, fat, vitamins, or minerals. Further exploration of the conditions associated with dietary-induced overeating in animals may provide insights into conditions related to obesity in man.

Age Factors↗
PubMed1976

New approaches to the management of severe acute pancreatitis.

A recent experience with seventy-seven patients admitted to Boston City Hospital for acute pancreatitis permitted us to identify thirteen patients (17 per cent) whom we diagnosed as having severe protracted acute pancreatitis. These alcoholic patients obviously had fulminant pancreatitis similar to that reported by others in two instances and pancreatic abscesses in two additional instances, but nine of the patients did not fulfill the criteria usually used by others as a basic for surgical intervention. Specific preoperative diagnosis was obtained in these patients by the aggressive use of endoscopic cannulation of the pancreatic ducts, which documented the presence of surgically correctable lesions. These patients had sustained significant malnutrition, which was corrected only by protracted therapy extending an average of two months and involving all modalities currently available for nutritional support of the severely ill patient. After proper preoperative identification of a specific lesion and correction of the malnutrition, the eleven patients without fulminant disease were operated on with no deaths or significant complication. Nine of the patients had elective procedures, which included six distal pancreatectomies and one total pancreatectomy. Thus, severe protracted acute pancreatitis can be identified, and once categrorized, it can have therapeutic implications.

Acute Disease↗
PubMed1975

Effort as a dimension of spontaneous activity in rats.

The relationship between effort and voluntary activity was studied in a braked running wheel and a voluntary treadmill. Effort was manipulated by varying the torque required to turn the wheel and by changing the angle of inclination of the treadmill. In both situations distance run was a linear decreasing function of effort, and work accomplished was a nonmonotonic increasing function of effort. These findings are discussed in relation to responsivity and regulatory views of the genesis of spontaneous activity.

Animals↗
PubMed1975

Septic lung and shock lung in man.

Two series of patients were studied by serial measurements of blood gas exchange and pulmonarmonary dysfunction and to evaluate the dangers of respiratory failure in post traumatic patients. There were 27 patients who had sustained profound hemorrhagic shock and massive blood replacement averaging 9.7 liters and 38 patients who suffered general peritonitis or other forms of fulminating nonthoracic sepsis. All were supported by endotrachael intubation and volume controlled ventilators. The overall mortality for the post shock patients without sepsis was 12% while in the septic patients it was 35%. The maximal pulmonary arteriovenous shunt encountered in the post hemorrhagic shock patients at 36 hours averaged 20 plus or minus 8% and was accompanied by high cardiac indices (average 5.1 plus or minus 1.3 L/M-2/min) but no significant rise of pulmonary arterial pressure or peak inspiratory pressure (PIP). Severe pulmonary dysfunction subsequently occurred only in those patients who later became septic. The studies on the septic patients were divided according to the magnitude of the cardiac indices (the high indices averaged 4.8 plus or minus 1.6L/M-2/min) and thelow indices averaged 1.9 plus or minus 1.0 L/M-2/min. In the former, the average maximal shunt of 30 plus or minus 6% was sustained for 4 or more days, accompanied by an elevation of PIP to 36 plus or minus 6 cm H2O and by Pa pressure of 28 plus or minus 5 mm Hg. The patients in low output septic shock usually had an associated bronchopneumonia and had an average venous admixture of 34 plus or minus 8% and PIP values of 41 plus or minus 8 cm H2O. The mean Pa pressure in this group was 29 plus or minus 6 mm Hg.

Adolescent↗