Biomedical subjects
E Heuser
Publications and source records attributed to E Heuser.
[Long-term prevention of duodenal ulcer with cimetidine. Effect of the rhythm of ingestion and drug compliance on the incidence of recurrence].
The long term effect of 400 mg cimetidine ingested at various times on ulcer recurrence and drug compliance was investigated in 66 patients with severe course of duodenal ulcer, now healed. Patients were randomised in 3 treatment groups: group A (n = 29) received 400 mg cimetidine in the evening, group B (n = 23) 200 mg both morning and evening, group C (n = 14) no treatment. Follow up examinations were at 3 month intervals. Ulcer recurrence was observed in 10 out of 14 patients in group C and in 12 out of 52 patients of groups A and B within the first 6 months. Due to the highly significant difference between the treated and untreated groups (P less than 0.001) the control group was discontinued. The recurrence rate after 12 months was identical in groups A and B (51 and 52%). Comparison of patients with and without recurrences showed no differences as regards length of history, maximal acid secretion, cimetidine compliance or endoscopic findings such as duodenitis, circular constriction of the bulbus or antral erosions. However, it was noticeable that smokers with 63% recurrent ulceration had a worse prognosis than the non-smokers with 37% (P = 0.06).
Diagnosis of hereditary nephritis by failure of glomeruli to bind anti-glomerular basement membrane antibodies.
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A fatal case of inappropriate ADH secretion induced by cyclophosphamide therapy.
Cyclophosphamide is used extensively to treat malignancies. A 5-year-old boy with stage IV neuroblastoma is described who developed a fatal syndrome of inappropriate antidiuretic hormone (ADH) secretion after high dose cyclophosphamide therapy.
[Cimetidin treatment of duodenal ulcer resistant to antacid therapy (author's transl)].
A selected group of 21 patients having received antacids (neutralizing capacity less than 50 meq HCl/d) as treatment for duodenal ulcers showed no improvement of the disease as demonstrated by endoscopic control after 8-16 weeks. Subsequent treatment of this group with 1 g Cimetidin/d for periods of 4-8 weeks was successful as far as healing of the ulcers is concerned in 85% of the cases, however symptoms of duodenitis persisted. In a control group of 39 patients which did not improve after 8 weeks of treatment with antacids the same therapy was continued for another 8 weeks; during this second period ulcers disappeared in 12 patients = 30% of the group. Improvement of symptoms resulted on the average after 6 days of therapy with cimetidine. One third of the patients treated with cimetidine relapsed with ulcers after approximately 4 months as demonstrated by endoscopy. Patients with duodenal ulcers resistant to therapy with antacids do represent a selected group suited to test the potency of new therapeutic methods as for instance treatment with cimetidine.
Detection of sialic acid containing compounds and the behaviour of gangliosides in polyacrylamide disc electrophoresis.
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Second renal transplants in children.
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Cyclophosphamide therapy of idiopathic nephrosis.
Thirty-three children with steroid-dependent or steroid-resistant idiopathic nephrosis were treated with a combination of cyclophosphamide and prednisone. Remission occurred in all 23 steroid-dependent patients and, at last report, 12 had gone without any medication for periods of from two months to 21 months without relapse. Remission occurred in five of ten steroid-resistant patients. The renal biopsy findings in these patients demonstrate a correlation between the "minimal change" lesion and a positive response to cyclophosphamide.
Identical 3-year-old twins with disseminated lupus erythematosus: one with nephrosis and one with nephritis.
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Thrombosis, nephrosis, and corticosteroid therapy.
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Hemolytic-uremic syndrome. Clinical and pathological considerations.
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Lymphomatoid granulomatosis in a child with acute lymphatic leukemia in remission.
Lymphomatoid granulomatosis, a tumor-like process of unknown etiology, produced progressively destructive disease of the larynx, trachea and bronchi in an eight-year-old girl with acute lymphoblastic leukemia of five years duration. The leukemia had been in remission for 4 1/2 years at the clinical onset of the lymphomatoid granulomatosis. Whether this occurrence suggests that lymphomatoid granulomatosis is a type of neoplasm, or is associated with immunologic depression, cannot be stated. Fortunately rare, and of poor prognosis, the disorder may become more frequent with improved survival rate of patients with leukemia and other neoplasms.