A rheumatoid arthritis was produced in rabbits according to the method described by Klinge. It was treated with a single dosage of 2 mCi Yttrium-90. After 3 weeks the animals treated with Yttrium showed less fibrosis of the synovial membrane than the controls. After 6 weeks the synovial membrane of the non-treated controls showed considerable fibrosis but the synovial villi of the treated animals were slender and largely unchanged.

Animals↗

PubMedDate not supplied

[Behaviour of synovial blood vessels in semi--thin sections in progressive chronic polyarthritis].

The synovial blood vessels of 17 patients with clinically definite rheumatoid arthritis (RA) were studied histologically and ultramicroscopically. No differences between seronegative and seropositive RA subjects were found. The abnormalities observed concerned mainly the endothelial cells, which showed changes varying in degree from swelling to fibroblastic transformation. The destruction of endothelial cells seemed to be linked with a positive test for C-reactive protein as a consequence of an acute relapse. Areas of cellular infiltration and partial homogenization were found in the tunica media of the vessel wall. There was a striking hyperemia of the capillaries and venules.

Adult↗

PubMedDate not supplied

[Viscosity of synovial fluid and its significance in rheumatic joint diseases].

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Adult↗

PubMedDate not supplied

[The presence of fluorescein-conjugated antibodies in synovial tissues of rheumatic joints].

With a modified Coons technique synovial tissue, anti human IgG, IgA, IgM, anti-coeruloplasmine, anti-transferrin, and anti-fibrin were investigated by means of immunofluorescence and evaluated with reference to place, type, and intensity of fluorescence. It was shown that fibrin deposits in the synovial tissue in rheumatoid synovitis do not only consist of the actual fibrin but often of immune complexes. These were mainly found near vessels and necroses, whereas unspecific fibrin was detected mainly in fibers and limiting areas. Coeruloplasmine and transferrin seem to have a marked affinity to pathogenetically changed fibers, whereas they do not combine with normal fibers. In seropositive RA remarkable immuno fluorescence was observed in vessels. From these facts certain etiological conclusions on rheumatoid diseases can be drawn.

Antigen-Antibody Complex↗