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Biomedical subjects

E Henriksen

Publications and source records attributed to E Henriksen.

47 records · Page 3Linked to original sources
PubMed1975

The lymphatic dissemination in endometrial carcinoma. A study of 188 necropsies.

To more clearly define the biologic activity of endometrial carcinoma, 188 cases selected at random were studied at necropsy. In 51 per cent of the cases death was attributed to the endometrial carcinoma. Observations demonstrate that dissemination is more scattered and less predictable than noted in cervical cancer; that the biologic potential is not invariably based on the site of the primary lesion, the depth of invasion, or the histologic differentiation. Difficulties in performing a thorough examination of the lymphatic system in this series include the increased age of the patients and a higher incidence of medical diseases and surgical procedures. The reported data illustrate the erratic natural history of the disease but do not permit the factual incidence of node or organ involvement. However, the potential viciousness of the disease is clearly demonstrated.

Adenocarcinoma↗
PubMedDate not supplied

The natural history of insulin-dependent diabetes mellitus in Denmark: 1. Long-term survival with and without late diabetic complications.

All 906 patients with insulin-dependent diabetes mellitus (IDDM) diagnosed before the age of 31 years, prior to 1943, and admitted to the Steno Memorial Hospital were followed until death or until 1 January 1984. In an attempt to identify factors of prognostic importance, we compared patients dying within 35 years of the onset of diabetes with patients surviving for 40 years or more. Three hundred and seventy-seven patients survived for 40 years or more; of these 224 were still alive and invited to a re-examination, in which 184 participated. After 40 years of diabetes, the most frequent complications were impaired vision (due to diabetic retinopathy) and persistent proteinuria. However, 53% had no major complications despite 40 years with IDDM. The 184 re-examined patients (median age 60 years, median diabetes duration 47 years) were all genuine IDDM patients, as defined by stimulated C-peptide levels. Proliferative retinopathy or visual impairment was found in 56% of the 184 patients, abnormal ECG or amputations in 26%, and elevated urinary albumin excretion rate (AER) greater than or equal to 30 mg/24 h) in 45%. Twenty-five per cent had none of these complications. Proliferative retinopathy was associated with elevated AER and raised systolic blood pressure, macroangiopathy with the use of antihypertensive drugs, and proteinuria with low age at diagnosis, large increase in systolic blood pressure, smoking, and insulin-binding antibodies. Sex, age and diabetes duration were not associated with any of these three late diabetic complications.

Adolescent↗
PubMedDate not supplied

The natural history of insulin-dependent diabetes in Denmark: 2. Long-term survival--who and why.

Forty per cent of all Danish insulin-dependent diabetic (IDDM) patients survive for at least 40 years after diagnosis. In an attempt to identify factors influencing the probability of surviving for 40 years or more, we followed all IDDM patients diagnosed before 1943 and admitted to the Steno Memorial Hospital. Patients surviving greater than or equal to 40 years were compared with patients dying within 35 years of diabetes diagnosis. Patients dying within 35 years were characterized by male preponderance (p less than 0.01), poor metabolic control (p less than 0.05), and by less frequent attendance at a specialized care unit (p less than 0.0001). Death due to uraemia/diabetic nephropathy was also characterized by male preponderance, poor metabolic control, and few contacts with a specialized care unit but in patients dying from cardiovascular disease (CVD), no effect of sex was found, indicating that the protection from CVD found in the female non-diabetic population is absent in IDDM patients. We conclude that long-term survival with IDDM may be determined by factors susceptible to intervention such as metabolic regulation and patient attitude to their disease.

Adult↗