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Biomedical subjects

E Hempel

Publications and source records attributed to E Hempel.

At least 55 records · Page 3Linked to original sources
PubMed1976

[The neurovegatative reaction-situation in climacteric. Modification of blood pressure regulation by estrogens].

48 women complaining of climacteric disorders were treated with an estrogen preparation for 1 year. Before an intervalls of 2 month during the treatment period studies of the Kupperman index, the vaginal karyopcnotic index and 3 neurovegatative (hemodynamic) tests were carried out: The orthostase-test according to Schellong, the cold-pressor-test according to Hines and Brown, the Pholedrin (Veritol-)test. During estrogen substitution the following alterations could be stated: A significant decrease of systolic and diastolic blood pressure values, a tendency of adjusting the systolic blood pressure values after standing up to the values in rest (Schellong-test I), a shortening of the interval needed to establish stable values of blood pressure and heart frequency, a tendency to reduce the increase of blood pressure in the cold pressor test, and a significant amplification of the increase of blood pressure and blood pressure amplitude in the Pholedrin test. These results are believed to indicate an alteration of vegetative reactivity in the parasympathicomimetic direction. Estrogens seem to exert a favourable influence on the mechanism of blood pressure regulation.

Adult↗
PubMed1975

[Vaginal cytological studies on the new delayed-action estrogen-ethinylestradiol sulfonate].

The colpocytologic efficacy of a new estrogen - ethinylestradiolsulfonate - has been studied in postmenopausal and fertile women. According to the depot character of the compound, ranging between ethinylestradiol and quinestrol, it exhibits a high and prolonged proliferative effect on the atropich vaginal epithelia. The weekly application of 1 mg of the substance in a contraceptive regimen causes a high grade of maturation with considerable individual differences. A single dose of 1 mg ethinylestradiolsulfonate quickly influences conditions of estrogen difficiency in the vaginal epithelia.

Contraceptives, Oral↗
PubMed1975

[Use of the depot estrogen ethinylestradiol sulfate in the therapy of menopausal syndrome].

Ethinylestradiol sulfonate is a newly developed orally effective derivate of ethinylestradiol with depot properties produced by "Jenapharm"-GDR. This depot estrogen has been proved for its usefullness in treating menopausal syndrom. A modified Kupperman-index had been used to check the therapeutic results. The effects concerning the endometrium were examined in postmenopausal women that atrophic character of endometrium had been ensured before. Ethinylestradiol sulfonate was applicated in the following dosages: 0,015 mg/day; 0,25 mg/week; 0,5 mg/week; 1,0 mg/week; 3 mg/month. The treatment with 0,25 mg/week over a period of 4 up to 6 weeks proved to be possible and effective if we take into account the endometrial reaction and the danger of bleeding. After the removal of the uterus higher dosages can be given. Up to a dose of 1 mg/week there were not to be seen subjective side effects. Ethinylestradiol sulfonate was compared with other oral estrogens.

Aged↗
PubMed1975

[Radioimmunologic studies on serum gonadotropic hormones during oral contraception].

In 10 women serum FSH- and LH-concentrations (radioimmunoassay) were measured daily throughout a complete cycle. 2 patients exhibited untreated biphasic menstrual cycles. 2 women were under the treatment of a combined estrogen - progestagen preparation, 1 woman was taking a sequential preparation, and 5 patients were treated with a weekly dose of a recently developed depot - estrogen (ethinylestradiolsulfonate). While the untreated women showed typical serum FSH-and LH-patterns characteristic of the biphasic menstrual cycle, patients on combined therapy were found to have a continuous low FSH- and LH-level except in the postmenstrual phase of the cycle, in which the values were slightly elevated. Serum-FSH-concentration in the woman on the sequential preparation remained constant throughout the treatment peroid, while serum LH-pattern showed multiple peaks. In the same manner, serum LH-patterns in women on the weekly depot- estrogen regimen were characterized by nearly regularly appearing LH-peaks, which seemed to be correlated with the estrogen intake. The cause and clinical significance of these findings are discussed.

Contraceptives, Oral↗