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Biomedical subjects

E Hemminki

Publications and source records attributed to E Hemminki.

At least 91 records · Page 5Linked to original sources

Practice of in-vitro fertilization: a case study from Finland.

In 1978 the first human IVF-baby was born. Today IVF is a standard procedure in the treatment of infertility in industrialized Western countries. In this study we analyzed how IVF reached an established position as a medical innovation in Finland, how IVF-care was organized between 1991-1993, and which kind of women used IVF-services and delivered a child as a result. The data sources were interviews with practicing IVF-physicians, a survey of Finnish IVF-clinics, telephone interviews with a sample of the adult population, and data of mothers from the Finnish Birth Registry. IVF in Finland followed the four stages of a medical innovation from a promising report into a standard procedure. Key factors in the introduction of IVF-methods were the work of andrologists', and later, IVF-physicians' associations, the approval of the method by head gynecologists in university clinics and among other colleagues, and later, the increase in IVF-services without regulatory government policy. IVF has become increasingly available in private clinics because pioneer physicians have established such services. In principle there was no social discrimination in having IVF, because it was available almost free of charge in public clinics. But the costs and availability of private clinics created unequal access to IVF services. IVF-women were more often upper-class white collar employees living in southern Finland than women in the control group. IVF has been a routine treatment option of infertility since the end of the 1980s. It has provided a medical technology solution to infertility. The supply and demand of IVF has increased and its indications have widened in the treatment of infertility. This is the inner logic of a successful technology: after the developmental processes of a revolutionary innovation, the use of technology escalates rapidly and the barriers for its use decrease.

Adult↗

The danger of overmatching in studies of the perinatal mortality and birthweight of infants born after assisted conception.

OBJECTIVE: To examine the impact of gestation length and plurality on short-term outcome of in vitro fertilization (IVF)-children. STUDY DESIGN: A register study using the Finnish Medical Birth Register for 1991-1993 (N = 194 383 newborns, of which 1335 were IVF-newborns). RESULTS: For IVF-newborns, a high proportion of multiple births (27%, odds ratio (OR) 19.67 compared with non-IVF births), low birth weight infants (30%, OR 7.94), and perinatal deaths (2.9%, OR 4.17) was found. The mothers' background did not explain the increased risks. After adjusting for gestation length and/or plurality, the odds ratios decreased significantly. CONCLUSION: Because of the high risk of plurality and premature births, matching the control group by gestation length and/or the number of multiples births may yield misleading results on the total health impact of IVF, and therefore it should be avoided.

Birth Weight↗

Long-term effects of cesarean sections: ectopic pregnancies and placental problems.

OBJECTIVE: Few studies on the long-term effects of cesarean sections exist. The purpose of this study was to investigate the occurrence of three long-term effects, ectopic pregnancy, placenta previa, and abruptio placentae, in the subsequent pregnancy. STUDY DESIGN: This retrospective cohort study was based on two nationwide registers in Finland: the birth register and the hospital inpatient register. Women (n = 16,938) having had a cesarean section (exposed women) and a matched control group were identified from the birth register. The occurrence and outcome of the first subsequent pregnancy was determined from the 1987 to 1993 hospital inpatient register and the first subsequent birth from the 1987 to 1993 birth register. RESULTS: During the follow-up time in the hospital inpatient register, fewer exposed women had a completed pregnancy. Ectopic pregnancy was more common among the exposed women than among the controls (risk ratio 1.28). In the first subsequent birth abruptio placentae was more common among primiparous (at index the birth, risk ratios of 3.22 in hospital inpatient register and 2.41 in birth register) and multiparous women (4.52 in hospital inpatient register and 3.89 in birth register). Placenta previa was more common among primiparous exposed women than among control women (risk ratio 5.34 in hospital inpatient register and 3.78 in birth register). CONCLUSIONS: Cesarean section is a modest risk factor for ectopic pregnancy and an important risk factor for placental problems.

Abruptio Placentae↗

Declining induced abortion rate in Finland: data quality of the Finnish abortion register.

BACKGROUND: Induced abortion rates have declined in Finland since 1973. A possible explanation offered has been that of deteriorating data collection. METHODS: To assess the completeness of the Register, we compared the information from a consecutive sample of hospital records (N = 482) to the Finnish Abortion Register in 18 hospitals in three counties. A smaller consecutive sample (N = 345) was collected from the same hospitals to assess the validity of the Register information. RESULTS: Only five abortions (1 percent) found in the hospitals were not reported in the Abortion Register. A total of 95 percent of all the length of pregnancy (definition problems), the classification of the abortion procedure, and social class (out-of-date classifications). Furthermore, early complications were poorly reported. CONCLUSIONS: The data from the Finnish Abortion Register are a reliable source for monitoring trends in the abortion rate and its variation by subgroups, but are an unreliable source for the study of the medical aspects of induced abortion.

Abortion, Induced↗

Impact of caesarean section on future pregnancy--a review of cohort studies.

Use of Caesarean sections has notably increased in many countries. This article reviews existing cohort type studies to compare subsequent reproduction after Caesarean section with a comparable control group, with exposure at the earliest in the 1960s. Eight studies were found. They suggested that a Caesarean section is a risk factor for lowered fertility, for uncompleted pregnancy (ectopic pregnancy and possibly miscarriage), for complications in the next pregnancy and birth (including placental complications) and for health problems in the next infant. The review was impeded by the lack of relevant research, and all studies to date potentially suffer from selection bias by indication. Trials and other studies on the long-term outcomes of Caesarean sections are needed, especially in populations with a high risk for reproductive problems.

Causality↗

Women's experiences of prenatal serum screening.

BACKGROUND: Maternal serum screening is used to detect pregnancies at risk for Down syndrome and neural tube defects, but most positive test results (6.6% of all) are false positives. This study examined the influence of positive test results on women's experiences of pregnancy. METHODS: The study population was all 67 pregnant women who received a positive result on serum screening in two Finnish towns from September 1993 to March 1994. For each case woman a control woman, matched for age, parity, education, and previous miscarriages, was selected. Of those invited, 45 case women and 46 control women (79%) responded to semistructured interviews. RESULTS: Of the 45 case women, 2 underwent termination of pregnancy after the diagnosis of an abnormality and 1 had a miscarriage. Of the remaining 42, 7 decided not to undergo further diagnostic tests, for 2 women the second serum test was normal, and 33 had amniocentesis or chorionic villus sampling. The positive screening result and wait for the final results negatively affected the emotional well-being of most of these 33 women, and 6 were still worried after receiving final reassuring results. Of the 46 control women, 17 felt some worry or fear regarding abnormality in their fetus. CONCLUSION: The significant negative psychosocial effects of serum screening should be taken into account by caregivers when deciding whether and how to institutionalize these tests as part of antenatal care.

Adult↗

Births by younger and older mothers in a population with late and regulated childbearing: Finland 1991.

PURPOSES: The aims of this study were: first, to ascertain the characteristics of younger and older mothers in the Finnish population; second, to assess the health conditions pertaining to births and newborns according to maternal age groups. METHODS: The data, 26,373 primiparous and 38,895 multiparous women, came from the 1991 nationwide Finnish birth register, and was completed using death and education registers. The younger (< 18 and 18-19 year olds) and older (35-39 and 40 and over) mothers were compared to 20-34 year olds. Infant outcomes were studied by adjusting for mothers' social and obstetric background characteristics by using stepwise logistic regression. RESULTS: Births were rare among women younger than 18 years or 40 years or older. Younger primiparous mothers (less than 20 years) were less often married, more often had a lower social class background, and tended to live in Northern Finland and used antenatal care somewhat less. Their pregnancies, giving birth and infant outcomes were similar to those of 20-34 years old mothers. Most older mothers were women having their families late, rather than having big families. Older primiparas (35 years or older) were less likely to be married, were more often highly educated and lived in urban areas and in the most southern county. Older mothers had more problems during pregnancy and labor, and their infant outcomes were worse. CONCLUSIONS: Our study supports the notion that for young mothers giving birth is a social rather than a medical problem, whereas the reverse is true for older mothers. However, perinatal results for most older mothers are good.

Adolescent↗

Long-term follow-up of mothers and their infants in a randomized trial on iron prophylaxis during pregnancy.

OBJECTIVE: A randomized trial comparing women who were given iron only if needed and those given iron prophylactically showed that routine prophylaxis is not crucial for mothers' or infants' health up to postpartum examination. This study investigated these infants' and mothers' subsequent health, as available in routine registers in a 7-year follow-up. STUDY DESIGN: Original data (N = 2693) were linked to the national population, birth, and hospital inpatient registers. RESULTS: The outcomes in the two groups were very similar: there were no statistically significant differences in deaths after birth, number or timing of infants' or mothers' hospitalizations, reasons for mothers' first hospitalization, number or timing of subsequent miscarriages or births, or problems or outcomes in the next birth. However, infants of the prophylactically supplemented group were more frequently hospitalized because of convulsions. CONCLUSION: This study does not support routine iron prophylaxis for well-nourished pregnant women.

Abortion, Spontaneous↗

Experience and opinions of climacterium by Finnish women.

OBJECTIVE: Literature on women's experiences with climacterium is mostly based on patients or on North American women. In this study, the experiences and opinions of Finnish women were investigated. STUDY DESIGN: In 1989, a questionnaire was sent to a representative sample of 45-64-year-old Finnish women (n = 2000); 1713 (86%) responded, of which 1308 were postmenopausal. RESULTS: Most women (87%) reported their health to be good or rather good. Symptoms were commonly experienced, but each symptom usually by a minority of women. Most subjective health problems were not related to climacterium as such, but were problems also encountered otherwise or related to aging. Some symptoms decreased with increased age, others increased or stayed the same. Comparing the symptoms reported in the past two weeks and women's own judgements suggests that hot flashes and irritability were specific to climacterium. Most women had a neutral or positive opinion of climacterium in general. CONCLUSION: Our study challenges the view that climacterium is a time of big subjective health problems.

Aging↗

Trends in the use of climacteric and postclimacteric hormones in Nordic countries.

The extent of menopausal and postmenopausal hormone use in Denmark, Finland, Norway, and Sweden during 1981-1992 was studied by means of drug sales figures and associations between hormone use, education, employment and occupational status, by questionnaire surveys in each of the respective countries in the 1980s-90s. According to sales figures, hormone use has been different in each of the countries studied. In 1981 use was three times more common in Denmark than in Norway. In 1992 use had increased in all the other countries except Denmark, and was highest in Finland and Sweden. Based on 1981 data for Norway, on 1987 data for Denmark and on 1989 data for Finland, use of hormone therapy was related to education, employment or occupational status in Finland but not in Denmark or Norway. Differences in the phases of innovation diffusion between these countries may offer a partial explanation for these results.

Climacteric↗

Is menopause withering away?

Menopause (cessation of menstruation) and the period surrounding it (climacterium) are often defined retrospectively by asking a woman the date of her last menstrual period (LMP). Based on a survey of 2000 women aged 45-64 in 1989 in Finland, this study examines (1) the relation between these definitions and women's own definition of their climacteric status and of the cessation of menstruation and (2) the effect of menopausal and postmenopausal hormone therapy and hysterectomy on the definition of menopause and climacterium. Agreement of the woman's own definition of her climacteric status and interval since LMP was 25% among current hormone users, 41% among hysterectomised women and 64% among those who were neither currently using hormones nor had been hysterectomised. Current hormone users defined the climacteric phase as longer than their LMP suggested. Current hormone use and hysterectomy had little effect on reported final cessation of menstrual periods. It is concluded that hysterectomy and hormone therapy shape women's thinking about the end of reproductive life, blur the concepts of menopause and postmenopause and confuse the measurement of age at menopause.

Adult↗

In-vitro fertilization pregnancies and perinatal health in Finland 1991-1993.

In 1993, in Finland at least 0.7% of all pregnancies ending in birth were assisted by in-vitro fertilization (IVF). The purpose of this study was to compare IVF mothers with other mothers, and the perinatal health and health care costs of IVF infants to those of other infants. The main source of information was the Medical Birth Register for 1991-1993 (n = 19,1712 pregnancies, of which 1015 were started by IVF). IVF mothers were more often older, married and primiparas. They started antenatal care earlier, had more visits than other mothers and more than 50% were hospitalized during their pregnancy. Every fourth IVF pregnancy was a multiple one. Both IVF singletons and multiples had poorer health than other infants. The new practice of implanting fewer embryos than before was introduced in 1992-1993, and a 50% decrease in triplet rate was found. At the same time, a somewhat better outcome for IVF newborns was found. However, every fourth child was still preterm or weighed < 2500 g. The health care costs for one IVF newborn from induction of pregnancy until the age of 7 days was 5.4-fold compared to other newborns. The subsequent health of IVF children has to be further studied to more fully assess the health impact of IVF.

Female↗

Physicians' experience with Norplant implantable contraceptives in Finland.

Norplant contraceptives are manufactured in Finland, but the majority of Norplant users live in the Third World. The objective of this study was to study Finnish family planning physicians experience with and attitudes towards Norplant contraceptives. Three data sources were used: (1) review of articles published in non-commercial Finnish medical journals between 1980 and 1990, (2) a sample of eleven physicians known to have experience with Norplant and chosen by a snow-ball method, and (3) a random sample of 22 physicians in charge of public family planning services stratified by municipality and degree of urbanization. The articles reflected a positive attitude towards Norplant, but the authors did not believe that Norplant should replace any previous method of contraception. In the random sample the amount of experience with Norplant was low. In both groups the general attitude towards Norplant was reserved. It was not used as a method of first choice, but was considered a good method for carefully selected women. Norplant was considered troublesome for the physician, requiring surgical procedures, producing side-effects and demanding time for counselling. Adequate use of Norplant calls for a good health care infrastructure, hygienic facilities and trained personnel. These are often lacking in Third World settings.

Attitude of Health Personnel↗

Data quality after restructuring a national medical registry.

The validity of the 1991 Finnish Medical Birth Registry data was assessed, with special emphasis on the effects of changes made to the data collection form in 1990. Data abstracted from medical records for all births occurring in 49 hospitals during a five-day sample period (n = 865) were compared to the register information. Good or satisfactory validity was found for 32 of 33 variables, when minor error was tolerated in variables with continuous scales. For diagnoses and procedures, recorded in check-box format, satisfactory validity was found for 10 of 45 variables. Validity could not be assessed for 18 variables because of insufficient number of cases (13 items) or definition problems (5 items). When the results were compared to a 1987 data quality study, many of the variables that had been changed to the check-box format showed improvement in validity. In addition, in some cases a small change in question alternatives or instructions caused a noticeable change in validity.

Abstracting and Indexing↗

Feedback for participants in a health survey: feasible and useful.

The use of quantitative methods has often limited the communication between researchers and research participants to being one-sided. Use of feedback in survey-oriented research is one possibility for creating a more communicative relationship. After doing a postal survey of 2000 Finnish 45 to 64-year-old women about their climacterium we produced a feedback leaflet about the main results of the study and about climacterium in general and sent it to all respondents (n = 1713). Later a postal questionnaire concerning the feedback leaflet was sent to a consecutive sample of every eighth (n = 200) woman, of whom 153 (76%) responded. Most of the women gave neutral or positive responses to the content of the leaflet. There was more interest in the feedback among the younger and pre-menopausal groups than among the older or postmenopausal women. Some women wanted more information about climacterium-related issues than was possible to give in the space of eight pages. According to this experiment, feedback offers fresh view-points and valuable critique for researchers as a result of being more in contact with respondents.

Communication↗

Perceptions and satisfaction among Norplant users in Finland.

OBJECTIVE: This study was designed to assess users' perceptions of and satisfaction with the Norplant contraceptive implant. METHODS: A questionnaire was mailed to all women having had Norplant inserted one or two years before the study initiation in seven public out-patient family-planning clinics in the capital area of Finland, of whom 82% responded (n = 207). RESULTS: Practically all women (97%) had experienced some side-effects and 72% considered at least one of them to be disruptive. Of these side-effects, bleeding irregularities proved most often bothersome during the first 6 months of use, but depression and nervousness were relatively more important reasons for early removal. Regardless of the ubiquity of side-effects, 78% were satisfied with Norplant. High satisfaction was common especially among older users with their second set of capsules. Dissatisfaction with the method was best explained by the experience of unexpected and disruptive side-effects. CONCLUSIONS: Our results suggest that mental problems related to Norplant use have received too little attention and that satisfaction is highest in carefully selected users among older women.

Adult↗