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Biomedical subjects

E Hegyi

Publications and source records attributed to E Hegyi.

At least 37 records · Page 2Linked to original sources
PubMed1989

Ultrastructural localization of platelet factor 4 in rat megakaryocytes and platelets by gold-labeled antibody detection.

The pattern of distribution of platelet factor 4 (PF-4) was studied in rat platelets and megakaryocytes following immunohistochemical labeling with a monoclonal antibody (2E7) specific for PF-4 and visualization by a protein A-gold complex. We observed a heterogeneity in PF-4 expression among alpha granules with a minority of them being unlabeled by immunoelectron microscopy, a pattern similar in both mature, circulating platelets and developing megakaryocytes. Furthermore, the majority of the labeled alpha granules in both cell types displayed a unique, eccentric localization of the PF-4 that was mainly over the nucleoid region within each granule. This localization is similar to the microtubular localization in alpha granules reported previously for von Willebrand factor and yet distinct from the reported random distribution of fibrinogen. We also observed significant labeling of small vesicular structures in developing megakaryocytes that may be involved in the transport of PF-4 and its packaging in platelet alpha granules. This new information is important in relating patterns of PF-4 biogenesis in megakaryocytes to conditions of alpha granular dysfunction in platelets.

Animals↗
PubMed1988

Hereditary angioedema in Czechoslovakia. Clinical, immunological, genetic and therapeutic studies of 16 families.

The analysis of the findings in 16 families with hereditary angioedema detected in Czechoslovakia over the years 1975-1986 is being presented. In 14 families C1-inhibitor deficiency and in two families afunction of C1-inhibitor was established. Of the total number of 175 examined family members C1-inhibitor defect was registered in 66 subjects (60 with deficiency and 6 with afunction), and of these 48 suffered from clinical symptoms of edematous attacks affecting the skin, larynx, intestine and urinary tract, whereas 18 subjects were asymptomatic. Genealogical studies confirmed that the defect is inherited as an autosomal dominant trait. In 16 patients long-term prophylactic treatment with Danol was introduced. The effective minimum dosage was tested individually for each patient.

Angioedema↗
PubMed1987

Epidemiology of nickel allergy.

In 2400 consecutive patients at 8 clinics in 5 countries, nickel hypersensitivity was found in 176 cases (7.3%), 19 male (2.1%) and 157 female (10.5%). The incidence ranged from 15 to 38 cases in 300 patients of every department (5.0% Sofia to 12.7% Erfurt). 60.6% of the nickel positives were schoolgirls or younger than 25 years. The exposure time was 3 years, in 49% 1 year or shorter. Most cases (75%) are not occupationally acquired, but due to costume jewelry (31.8%), wrist watches (23.3%), metal clothing buckles (3.4%) including jeans buttons. Job dependent nickel dermatitis is often (36/51 cases) linked with wet work. Atopic dermatitis was found in 8.3% of female nickel allergy. Nickel positivity without a dermatitis history was seen in 9/176 cases (5%). Nickel allergy will become a sex-indifferent phenomenon in Europe, because of the changing customs of adornment.

Dermatitis, Contact↗
PubMed1984

[Overview of the allergens from several feeder regions of Czechoslovakia. Incidence and prevalence of contact hypersensitivity caused by the allergens spread by the population of the feeder areas of Bratislava, Trnava and Banská Bystrica 1978-1980].

With the aid of patch tests an investigation involving 3060 patients was carried out to register the incidence and prevalence of allergens of the standard and supplementary test series. The standard series with 16 allergens was selected in cooperation with the work group for curtailing contact dermatitis and occupational dermatoses in the socialist countries. The Czechoslovakian supplementary test series included three allergens: neomycin sulfate, extr . chamomillae and resorcinol. In 22.6% of the 693 patients the skin tests were positive for at least one allergen. The most frequent eczematogenic among men was potassium dichromate (resulting from contact with cement), among women nickel sulfate, and in the group as a whole Peruvian balm. The age groups most affected were between 41 and 50 years and between 51 and 60 years, respectively, for men, between 21 and 30 years for women, and between 21 and 30 years for the group as a whole. In registering the prevalence, chamomillae extract caused the highest occurrence among men, cobalt nitrate among the women, and also cobalt nitrate for the group as a whole. The age group affected most was between 51 and 60 years. In the complete investigative study of incidence and prevalence, Peruvian balm topped the list for the group as a whole, potassium dichromate for the men, and nickel sulfate for the women. Among the men and for the group as a whole the most affected age group was between 51 and 60 years, and among the women between 21 and 30 years.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1981

[Cytophagic panniculitis].

A case of cytophagic panniculitis is presented. The criteria that let this form of panniculitis differentiate from the Pfeiffer-Weber-Christian disease are discussed.

Female↗