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Biomedical subjects

E Hazan

Publications and source records attributed to E Hazan.

160 records · Page 9Linked to original sources
PubMedDate not supplied

The effect of aprotinin (trasylol) on postoperative bleeding in cyanotic congenital heart disease.

Despite the widespread clinical success in open-heart surgery, bleeding after cardiopulmonary by-pass (CPB) has been a common problem especially in cyanotic congenital heart disease. Recently, there have been reports demonstrating that treatment with high doses of aprotinin reduces postoperative bleeding. We studied the effect of aprotinin on postoperative bleeding in patients with tetralogy of Fallot who had undergone total correction in the Department of Thoracic and Cardiovascular Surgery of the Hacettepe University Faculty of Medicine, and compared our results with those in the literature. Ten patients out of 20 in the study were given high doses of aprotinin and were compared with the remaining 10 patients who had not received the drug. Standard anesthesia, perfusion and surgical techniques were used in all operations. The total amount of bleeding in the aprotinin-treated group was found to be 1530 ml, while in the other group it was 4185 ml (p < 0.05). The total quantity of blood transfused in the aprotinin-treated patients was 3250 ml while it was 5865 ml in the control group (p < 0.05). No significant effect of aprotinin was found on Hb, Hct, PT, aPTT and thrombocyte counts (p > 0.05). However, the effect of the drug on bleeding and coagulation time was found to be statistically significant (p < 0.05).

Aprotinin↗
PubMedDate not supplied

[Surgical treatment of complex forms of congenital heart malformations associated with situs inversus (nine cases) (author's transl)].

Although are, situs inversus is nevertheless encountered in the surgical treatment of heart malformations. This series concerns 1 000 patients who where operated with heart-lung by-pass between 1974 and 1977. In nine cases, the heart was in the situs inversus position and the cardiac malformations associated with this condition, were complex. Yet the results were comparable to those obtained when the heart was in the normal position.

Abnormalities, Multiple↗
PubMedDate not supplied

[Aorto-pulmonary windows. Report of fifteen cases (author's transl)].

Fifteen aorto-pulmonary windows have been operated on patients 1,5 months to 6 years old. 6 were associated with other cardiac malformations (ductus arteriosus, VSD, mitral insufficiency, aortic arch atresia). 5 cases died. 3 had other cardiac malformations associated. 10 have an average follow-up of 5 1/2 years. The authors insist on the severity of the cases with high pulmonary pressure, and advise operation during the first year of life.

Aorta↗
PubMedDate not supplied

Reversible renal failure secondary to severe compensated aortic regurgitation.

Severe renal failure associated with proteinuria occurred in a 21-year patient, who had massive rheumatic aortic regurgitation. There was no sign of congestive heart failure or extra-cellular dehydration. Subacute bacterial endocarditis was ruled out by appropriate laboratory investigations. Prosthetic aortic valve replacement resulted in normalization of the renal function and marked reduction of proteinuria. Renal histology showed severe sclerotic endarteritis involving predominantly the large arteries, and membrano-proliferative-like glomerulopathy without immune deposits. The role of the massive aortic regurgitation in the production of renal failure and histologic alterations is suggested.

Acute Kidney Injury↗